SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
PAXT-1
(Caenorhabditis
elegans) 		6 / 12 LEU B  45
LEU B  42
CYH B  41
LEU B  39
TYR B  34
ILE A 652
 None
 1.34A 1s9pC-5firB:
undetectable		 1s9pC-5firB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 ASP A  49
ASN A  50
THR A 244
 None
 0.48A 2pymB-5firA:
undetectable		 2pymB-5firA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5fir PAXT-1
(Caenorhabditis
elegans) 		3 / 3 LEU B  39
TYR B  34
GLN B  38
 None
 0.75A 2wekA-5firB:
undetectable		 2wekA-5firB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 LEU A 346
TRP A 566
TYR A 592
 None
 0.87A 3aicA-5firA:
undetectable		 3aicA-5firA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 LEU A 346
TRP A 566
TYR A 592
 None
 0.88A 3aicB-5firA:
undetectable		 3aicB-5firA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 LEU A 346
TRP A 566
TYR A 592
 None
 0.89A 3aicE-5firA:
undetectable		 3aicE-5firA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 LEU A 346
TRP A 566
TYR A 592
 None
 0.87A 3aicF-5firA:
undetectable		 3aicF-5firA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 LEU A 346
TRP A 566
TYR A 592
 None
 0.88A 3aicG-5firA:
undetectable		 3aicG-5firA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 LEU A 346
TRP A 566
TYR A 592
 None
 0.91A 3aicH-5firA:
undetectable		 3aicH-5firA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		5 / 12 TYR A 547
TYR A 568
VAL A 564
PHE A 403
TYR A 546
 None
 1.45A 3apwA-5firA:
undetectable		 3apwA-5firA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 7 VAL A 638
LYS A 642
ILE A 645
GLN A 646
 None
SO4  A1791 (-3.1A)
None
SO4  A1791 (-3.7A)
 0.56A 3bjwB-5firA:
undetectable		 3bjwB-5firA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 5 VAL A  18
VAL A  19
GLN A  46
PHE A 300
 None
 1.39A 3bjwH-5firA:
undetectable		 3bjwH-5firA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 5 VAL A  18
VAL A  19
GLN A  46
PHE A 300
 None
 1.34A 3bjwB-5firA:
undetectable		 3bjwB-5firA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		5 / 12 PHE A 249
THR A  17
VAL A  18
LEU A 240
ILE A 242
 None
 1.06A 3elzA-5firA:
undetectable		 3elzA-5firA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 8 ALA A 190
ILE A 192
ASN A 191
PRO A  94
 None
 0.94A 3fxrA-5firA:
undetectable		 3fxrA-5firA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		5 / 12 LYS A 110
ILE A  59
ILE A 161
SER A 158
PRO A  61
 SO4  A1788 (-3.2A)
None
None
None
None
 1.22A 3kpbA-5firA:
undetectable		 3kpbA-5firA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		5 / 12 LYS A 110
ILE A  59
ILE A 161
SER A 158
PRO A  61
 SO4  A1788 (-3.2A)
None
None
None
None
 1.21A 3kpbC-5firA:
undetectable		 3kpbC-5firA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
PAXT-1
(Caenorhabditis
elegans) 		4 / 8 TYR A 655
LEU A 676
PHE A 119
TYR B  56
 None
 1.35A 3po7A-5firA:
undetectable		 3po7A-5firA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		5 / 12 LEU A 196
ALA A 101
ASN A  56
ILE A  85
ILE A  81
 None
None
SO4  A1788 (-4.7A)
None
None
 1.17A 3ut5B-5firA:
undetectable		 3ut5B-5firA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 ARG A 406
LYS A 666
ARG A 355
 None
 1.38A 3w1wA-5firA:
2.8
3w1wB-5firA:
3.2		 3w1wA-5firA:
19.07
3w1wB-5firA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 ARG A 355
ARG A 406
LYS A 666
 None
 1.30A 3w1wA-5firA:
2.8
3w1wB-5firA:
3.2		 3w1wA-5firA:
19.07
3w1wB-5firA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 ASP A 785
ARG A 214
LYS A 215
 None
 1.10A 3wipG-5firA:
undetectable		 3wipG-5firA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 7 HIS A 228
ASN A  50
TYR A  52
LEU A  97
 None
 1.22A 4awuA-5firA:
undetectable		 4awuA-5firA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 5 PRO A  43
ASN A  44
ILE A  91
VAL A  19
 None
 1.36A 4hytA-5firA:
3.2		 4hytA-5firA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		6 / 12 GLY A 104
PRO A 202
GLY A 203
ASN A 200
ILE A 161
LEU A 171
 None
 1.49A 4n49A-5firA:
undetectable		 4n49A-5firA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		5 / 12 HIS A 228
ASP A  49
ILE A 710
HIS A 716
SER A 718
 None
 1.25A 4pooB-5firA:
3.8		 4pooB-5firA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		5 / 12 GLY A 205
ARG A 253
ASP A 236
ASP A 344
GLU A 204
 None
 1.45A 4qc6B-5firA:
undetectable		 4qc6B-5firA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		5 / 12 GLY A 205
ASP A 234
ASP A 344
HIS A 207
GLU A 204
 None
 1.34A 4qc6B-5firA:
undetectable		 4qc6B-5firA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 VAL A 564
ALA A 595
PHE A 590
 None
 0.87A 4z4iA-5firA:
2.5		 4z4iA-5firA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		5 / 12 LEU A 385
VAL A 569
GLY A 342
PHE A 336
LEU A 352
 None
 1.15A 5byjA-5firA:
undetectable		 5byjA-5firA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 7 ILE A 192
ILE A 179
ILE A  85
LEU A 196
 None
 0.77A 5fukA-5firA:
undetectable
5fukB-5firA:
undetectable		 5fukA-5firA:
16.30
5fukB-5firA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 6 LYS A 110
ALA A 109
VAL A 575
TYR A 578
 SO4  A1788 (-3.2A)
None
None
None
 0.88A 5i8fA-5firA:
1.3		 5i8fA-5firA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 6 GLU A  76
ALA A 174
LEU A 175
TYR A  84
 None
 1.03A 5igiA-5firA:
undetectable		 5igiA-5firA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 VAL A 564
ALA A 595
PHE A 590
 None
 0.88A 5js1A-5firA:
undetectable		 5js1A-5firA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 7 GLY A 232
ASP A 234
ASP A 236
GLY A 205
 None
 0.58A 5kqyB-5firA:
undetectable		 5kqyB-5firA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 8 GLY A 232
ASP A 234
ASP A 236
GLY A 205
 None
 0.63A 5kr1B-5firA:
undetectable		 5kr1B-5firA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 THR A 615
SER A 585
ASP A 610
 None
 0.76A 5kvaA-5firA:
undetectable		 5kvaA-5firA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		3 / 3 THR A 615
SER A 585
ASP A 610
 None
 0.75A 5kvaB-5firA:
undetectable		 5kvaB-5firA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 6 ILE A 102
MET A  55
ASN A  56
ASP A  54
 None
None
SO4  A1788 (-4.7A)
None
 1.12A 6dhbA-5firA:
undetectable		 6dhbA-5firA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
(Caenorhabditis
elegans) 		4 / 5 GLY A 743
LEU A 741
TYR A 212
GLN A 216
 None
 0.78A 6ji6A-5firA:
undetectable		 6ji6A-5firA:
16.90