SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5fis EXD1
(Bombyx
mori) 		5 / 10 ALA B 116
LEU B 181
LEU B 162
SER B 136
LEU B 135
 None
 1.05A 2xn7A-5fisB:
undetectable
2xn7B-5fisB:
undetectable		 2xn7A-5fisB:
20.45
2xn7B-5fisB:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5fis EXD1
(Bombyx
mori) 		4 / 6 VAL B 192
LYS B 169
VAL B 106
ILE B 115
 None
 0.98A 3mssD-5fisB:
undetectable		 3mssD-5fisB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5fis EXD1
(Bombyx
mori) 		3 / 3 TYR B 224
ASP B 194
ASP B 199
 None
 0.84A 3r24A-5fisB:
undetectable		 3r24A-5fisB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5fis EXD1
(Bombyx
mori) 		4 / 5 LEU B 135
ALA B 105
PHE B 102
ASN B 110
 None
 1.40A 3uq6A-5fisB:
undetectable		 3uq6A-5fisB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 5fis EXD1
(Bombyx
mori) 		5 / 12 ILE B 170
THR B 195
LEU B 221
GLY B 218
ILE B 258
 None
 1.05A 4c9lA-5fisB:
undetectable		 4c9lA-5fisB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 5fis EXD1
(Bombyx
mori) 		5 / 12 ILE B 170
THR B 195
LEU B 221
GLY B 218
ILE B 258
 None
 1.03A 4c9oA-5fisB:
undetectable		 4c9oA-5fisB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 5fis EXD1
(Bombyx
mori) 		5 / 12 ILE B 170
THR B 195
LEU B 221
GLY B 218
ILE B 258
 None
 1.03A 4c9oB-5fisB:
undetectable		 4c9oB-5fisB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5fis EXD1
(Bombyx
mori) 		5 / 12 LEU B 261
ASP B 194
SER B 191
SER B 136
ILE B 115
 None
 1.09A 4ky8B-5fisB:
undetectable		 4ky8B-5fisB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5fis EXD1
(Bombyx
mori) 		5 / 12 LEU B 261
ASP B 194
SER B 191
SER B 136
ILE B 115
 None
 1.08A 4ky8D-5fisB:
undetectable		 4ky8D-5fisB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 5fis EXD1
(Bombyx
mori) 		5 / 12 ILE B 161
ALA B 153
LEU B 135
LEU B 133
PHE B 102
 None
 1.34A 4pbhA-5fisB:
undetectable		 4pbhA-5fisB:
18.51