SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		4 / 6 LEU A 103
THR A  38
ALA A  36
LEU A  34
 None
 1.18A 1etb2-5fjpA:
undetectable		 1etb2-5fjpA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		4 / 7 LEU A 146
VAL A 149
GLY A 150
VAL A 184
 None
 0.61A 1p2yA-5fjpA:
undetectable		 1p2yA-5fjpA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 12 LEU A  31
LEU A  32
MET A 105
THR A 329
ILE A 328
 None
 1.26A 1p93A-5fjpA:
undetectable		 1p93A-5fjpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 10 GLY A 296
GLU A 294
SER A 320
ASP A 327
ILE A 328
 None
 1.36A 1pw7A-5fjpA:
undetectable		 1pw7A-5fjpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		4 / 9 ILE A 242
ALA A 273
VAL A 276
CYH A 280
 None
 1.02A 2vufB-5fjpA:
undetectable		 2vufB-5fjpA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 11 GLY A 293
GLU A  46
GLY A 296
ASP A 327
ILE A 328
 NPQ  A1369 ( 4.1A)
None
None
None
None
 1.01A 2x1lA-5fjpA:
undetectable		 2x1lA-5fjpA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 12 GLY A 293
GLU A  46
GLY A 296
ASP A 327
ILE A 328
 NPQ  A1369 ( 4.1A)
None
None
None
None
 1.02A 2x1lB-5fjpA:
undetectable		 2x1lB-5fjpA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 11 GLY A 293
GLU A  46
GLY A 296
ASP A 327
ILE A 328
 NPQ  A1369 ( 4.1A)
None
None
None
None
 1.03A 2x1lC-5fjpA:
undetectable		 2x1lC-5fjpA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 10 TRP A 168
VAL A 188
ILE A 164
LEU A 146
ALA A 175
 None
 1.27A 2xf3A-5fjpA:
undetectable		 2xf3A-5fjpA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 9 TRP A 168
VAL A 188
ILE A 164
LEU A 146
ALA A 175
 None
 1.26A 2xf3B-5fjpA:
undetectable		 2xf3B-5fjpA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 9 TRP A 168
VAL A 188
ILE A 164
LEU A 146
ALA A 175
 None
 1.21A 2xfsB-5fjpA:
undetectable		 2xfsB-5fjpA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 9 TRP A 168
VAL A 188
ILE A 164
LEU A 146
ALA A 175
 None
 1.25A 2xh9B-5fjpA:
undetectable		 2xh9B-5fjpA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		3 / 3 LYS A 363
GLU A   7
TRP A 365
 None
 1.08A 3v4tH-5fjpA:
undetectable		 3v4tH-5fjpA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 12 LEU A  90
ALA A  63
GLU A  58
GLY A 101
GLY A 269
 None
 1.21A 4hfpB-5fjpA:
undetectable		 4hfpB-5fjpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		3 / 3 TYR A 324
ARG A 299
SER A 320
 None
 1.10A 4lf7I-5fjpA:
undetectable
4lf7J-5fjpA:
undetectable		 4lf7I-5fjpA:
21.74
4lf7J-5fjpA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		3 / 3 TYR A 324
ARG A 299
SER A 320
 None
 1.10A 4lf8I-5fjpA:
undetectable
4lf8J-5fjpA:
undetectable		 4lf8I-5fjpA:
21.74
4lf8J-5fjpA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		5 / 12 ALA A 350
ARG A 113
GLY A 346
ALA A 102
MET A 105
 None
 1.27A 4r29A-5fjpA:
undetectable		 4r29A-5fjpA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 5fjp O-SUCCINYLBENZOATE
SYNTHASE
(Amycolatopsis
sp.) 		4 / 6 TYR A 157
TYR A 152
PHE A  19
TYR A 323
 None
None
NPQ  A1369 (-3.8A)
NPQ  A1369 (-4.3A)
 1.08A 5e2iA-5fjpA:
1.5		 5e2iA-5fjpA:
21.86