SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5fk0 COATOMER SUBUNIT
DELTA
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 543
ILE A 397
PHE A 500
LEU A 314
VAL A 298
 None
 1.38A 2w98A-5fk0A:
undetectable		 2w98A-5fk0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5fk0 COATOMER SUBUNIT
DELTA
(Saccharomyces
cerevisiae) 		5 / 12 SER A 410
VAL A 457
ASP A 444
ILE A 445
ASN A 446
 None
 1.45A 3jayA-5fk0A:
undetectable		 3jayA-5fk0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5fk0 COATOMER SUBUNIT
DELTA
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 318
LEU A 334
SER A 365
THR A 361
 None
 0.97A 3lm8A-5fk0A:
undetectable
3lm8C-5fk0A:
undetectable		 3lm8A-5fk0A:
19.86
3lm8C-5fk0A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5fk0 COATOMER SUBUNIT
DELTA
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 411
THR A 484
ASP A 444
 None
 0.89A 5k9dA-5fk0A:
undetectable		 5k9dA-5fk0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5fk0 COATOMER SUBUNIT
DELTA
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 443
ILE A 445
ASN A 446
THR A 447
ILE A 468
 None
 1.26A 5y80A-5fk0A:
undetectable		 5y80A-5fk0A:
13.33