SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 11 LEU A1063
GLY A 979
GLY A 978
LEU A1019
LEU A1026
 None
 1.15A 1mx1A-5fkuA:
undetectable		 1mx1A-5fkuA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 8 THR A 995
ALA A 997
LEU A 999
VAL A1050
 None
 0.69A 1sn5C-5fkuA:
undetectable		 1sn5C-5fkuA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 7 THR A 995
ALA A 997
LEU A 999
VAL A1050
 None
 0.97A 1tyrB-5fkuA:
undetectable		 1tyrB-5fkuA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 10 ASP A 401
GLY A 367
GLY A 365
SER A 368
PHE A 341
 None
 1.30A 1w76B-5fkuA:
undetectable		 1w76B-5fkuA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 LEU A  97
LEU A 100
ILE A 101
ARG A 107
LEU A 128
 None
 0.90A 1xdkB-5fkuA:
undetectable		 1xdkB-5fkuA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5fku DNA POLYMERASE III
SUBUNIT TAU
(Escherichia
coli) 		5 / 11 LEU E 576
VAL E 539
ALA E 543
LEU E 541
LEU E 572
 None
 1.32A 2c12F-5fkuE:
undetectable		 2c12F-5fkuE:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 6 ASP A 790
THR A 606
GLU A 612
GLU A 803
 None
 1.38A 2dttB-5fkuA:
undetectable
2dttC-5fkuA:
undetectable		 2dttB-5fkuA:
6.64
2dttC-5fkuA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 ILE A  18
HIS A  12
GLY A  67
LEU A  27
MET A 240
 None
 1.37A 2nyrB-5fkuA:
2.3		 2nyrB-5fkuA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 LEU A  47
PHE A 541
GLN A  95
PRO A  64
VAL A 271
 None
 1.36A 2qd4A-5fkuA:
1.5		 2qd4A-5fkuA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 LEU A  47
PHE A 541
GLN A  95
PRO A  64
VAL A 271
 None
 1.38A 2qd4B-5fkuA:
undetectable		 2qd4B-5fkuA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 5 LEU A 637
ASP A 630
ALA A 633
ILE A 652
 None
 1.17A 2qhfA-5fkuA:
undetectable		 2qhfA-5fkuA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 8 ASN A  71
TYR A 234
ASP A  69
ARG A  10
 None
 1.10A 2v57A-5fkuA:
undetectable		 2v57A-5fkuA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 8 ASN A  71
TYR A 234
ASP A  69
ARG A  10
 None
 1.10A 2v57C-5fkuA:
undetectable		 2v57C-5fkuA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 HIS A   8
MET A  36
MET A 240
 None
 1.03A 2vj1A-5fkuA:
undetectable		 2vj1A-5fkuA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 ILE A 835
ILE A 816
ALA A 887
VAL A 878
LEU A 874
 None
 1.22A 3a51E-5fkuA:
3.1		 3a51E-5fkuA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 11 ALA A 185
LEU A 182
ILE A 171
GLY A 134
SER A 132
 None
 1.49A 3bpxA-5fkuA:
undetectable
3bpxB-5fkuA:
undetectable		 3bpxA-5fkuA:
8.49
3bpxB-5fkuA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 ALA A 837
GLY A 952
GLU A 953
VAL A 798
THR A 794
 None
 1.15A 3c6gB-5fkuA:
undetectable		 3c6gB-5fkuA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 GLU A 389
SER A 368
VAL A 370
 None
 0.76A 3eeoA-5fkuA:
undetectable		 3eeoA-5fkuA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 11 ARG A 295
VAL A 331
PRO A 394
ILE A 376
PRO A 381
 None
 1.50A 3ganA-5fkuA:
undetectable		 3ganA-5fkuA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 PHE A 541
VAL A 546
SER A 428
ILE A 522
VAL A 516
 None
 1.16A 3iw1A-5fkuA:
undetectable		 3iw1A-5fkuA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 7 PHE A 391
GLY A 367
PHE A 388
PHE A 337
 None
 1.04A 3ko0D-5fkuA:
undetectable
3ko0E-5fkuA:
undetectable		 3ko0D-5fkuA:
6.92
3ko0E-5fkuA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 6 ILE A 101
ILE A  65
GLY A  67
VAL A 271
 None
 0.94A 3n3iA-5fkuA:
undetectable		 3n3iA-5fkuA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 ILE A 850
ARG A 895
ILE A 883
ILE A 835
ALA A 848
 None
 1.23A 3ohtA-5fkuA:
undetectable
3ohtB-5fkuA:
undetectable		 3ohtA-5fkuA:
16.88
3ohtB-5fkuA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 TYR A 239
GLU A 214
TYR A 234
 None
 0.76A 3ug8A-5fkuA:
3.5		 3ug8A-5fkuA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5fku DNA POLYMERASE III
SUBUNIT TAU
(Escherichia
coli) 		4 / 8 ASN E 593
ASP E 591
VAL E 596
HIS E 555
 None
 1.17A 4f5zA-5fkuE:
undetectable		 4f5zA-5fkuE:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 TYR A 234
HIS A  12
ARG A 203
 None
 1.05A 4htfA-5fkuA:
undetectable		 4htfA-5fkuA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 5 ASP A1145
ASN A1144
ILE A1086
VAL A1136
 None
 0.99A 4hytA-5fkuA:
undetectable		 4hytA-5fkuA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 PRO A 625
LEU A 634
VAL A 608
TYR A 769
PHE A 628
 None
 1.50A 4ifyA-5fkuA:
2.6		 4ifyA-5fkuA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 8 THR A 995
ALA A 997
LEU A 999
VAL A1050
 None
 0.96A 4ik6B-5fkuA:
undetectable		 4ik6B-5fkuA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 GLY A  93
GLY A 127
ASN A  91
ILE A 101
LEU A  47
 None
 0.90A 4n49A-5fkuA:
undetectable		 4n49A-5fkuA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 8 GLU A 974
ASP A1021
SER A1023
ARG A1022
 None
 1.12A 4uhxA-5fkuA:
undetectable		 4uhxA-5fkuA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 8 GLU A 974
ASP A1021
SER A1023
ARG A1022
 None
 1.12A 4uhxA-5fkuA:
undetectable		 4uhxA-5fkuA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 LEU A 999
GLY A 958
LEU A 959
ASP A1020
VAL A 801
 None
 1.21A 4wnwA-5fkuA:
0.0		 4wnwA-5fkuA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 6 LEU A 292
GLU A 289
ASN A 333
ILE A 332
 None
 0.74A 4ww7A-5fkuA:
undetectable		 4ww7A-5fkuA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 MET A 469
ASP A1058
PHE A1059
 None
 1.04A 4xeyA-5fkuA:
undetectable		 4xeyA-5fkuA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 MET A 469
ASP A1058
PHE A1059
 None
 1.03A 4xeyB-5fkuA:
0.2		 4xeyB-5fkuA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 VAL A 217
PHE A 210
ARG A 175
 None
 0.97A 4xr4B-5fkuA:
undetectable		 4xr4B-5fkuA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 ARG A 868
ASP A 864
TYR A 858
 None
 0.92A 4yo9B-5fkuA:
undetectable		 4yo9B-5fkuA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 5 PHE A 556
ASP A 405
PHE A 406
VAL A 515
 None
 0.96A 5a1rA-5fkuA:
2.0		 5a1rA-5fkuA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 4 LEU A 130
ARG A 266
ILE A 129
ILE A 263
 None
 1.23A 5dzk2-5fkuA:
undetectable
5dzkM-5fkuA:
undetectable
5dzkN-5fkuA:
undetectable		 5dzk2-5fkuA:
2.60
5dzkM-5fkuA:
10.50
5dzkN-5fkuA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 4 ALA A  33
PRO A  37
LEU A   9
HIS A   8
 None
 1.48A 5eskA-5fkuA:
2.9		 5eskA-5fkuA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_A_URFA301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 4 ARG A 203
ASP A  19
HIS A  83
ARG A  10
 None
 1.45A 5iaoA-5fkuA:
0.0		 5iaoA-5fkuA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.02A 5m45A-5fkuA:
undetectable		 5m45A-5fkuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.07A 5m45D-5fkuA:
undetectable		 5m45D-5fkuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.01A 5m45G-5fkuA:
undetectable		 5m45G-5fkuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.08A 5m45J-5fkuA:
undetectable		 5m45J-5fkuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 LEU A 144
GLY A 140
ARG A  10
TYR A 181
GLU A 169
 None
 1.49A 5m6gA-5fkuA:
undetectable		 5m6gA-5fkuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 7 PRO A 814
TYR A 833
ILE A 838
ILE A 835
ILE A 816
 None
 1.47A 5murB-5fkuA:
2.2		 5murB-5fkuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 LEU A 494
MET A 436
ILE A 215
ALA A 212
ILE A 219
 None
 0.88A 5nm5B-5fkuA:
undetectable		 5nm5B-5fkuA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 7 THR A 432
PHE A 556
GLN A 429
MET A 408
 None
 1.14A 5u6mA-5fkuA:
undetectable		 5u6mA-5fkuA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 PHE A 347
PHE A 406
ILE A 415
ALA A 419
ALA A 518
 None
 1.06A 5veuA-5fkuA:
undetectable		 5veuA-5fkuA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 GLY A 703
ASN A 393
ARG A 709
 None
 0.64A 5w7bD-5fkuA:
undetectable		 5w7bD-5fkuA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		3 / 3 TYR A1119
ASP A1123
ASP A1090
 None
 0.81A 5x6yA-5fkuA:
undetectable		 5x6yA-5fkuA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		5 / 12 TYR A 681
PHE A 651
LEU A 623
ALA A 633
LEU A 634
 None
 1.43A 5zwrB-5fkuA:
undetectable		 5zwrB-5fkuA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5fku DNA POLYMERASE III
SUBUNIT ALPHA
(Escherichia
coli) 		4 / 8 ILE A 415
GLN A 429
VAL A 515
PRO A 537
 None
 0.94A 6cduG-5fkuA:
2.3
6cduH-5fkuA:
2.2		 6cduG-5fkuA:
14.78
6cduH-5fkuA:
14.78