SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 12 ARG A 301
GLU A 292
ILE A 273
LEU A 270
ILE A 247
 None
 1.00A 1d1gA-5fl3A:
undetectable		 1d1gA-5fl3A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 10 SER A 236
LEU A 225
VAL A 262
PHE A 254
VAL A 221
 None
 1.48A 1q23K-5fl3A:
undetectable		 1q23K-5fl3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 12 GLY A 272
LEU A 135
VAL A 300
LEU A 294
ILE A 313
 None
 0.95A 1zq9B-5fl3A:
undetectable		 1zq9B-5fl3A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 11 ALA A 316
LEU A 266
LEU A 270
LEU A 294
LEU A 304
 None
 0.98A 2ceoA-5fl3A:
undetectable		 2ceoA-5fl3A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		4 / 6 LEU A 233
GLY A 231
LEU A 235
SER A 236
 None
 0.93A 3aiaA-5fl3A:
undetectable		 3aiaA-5fl3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		4 / 7 THR A 148
GLN A 276
LEU A 278
LEU A 289
 ADP  A 400 (-3.3A)
None
ADP  A 400 (-4.5A)
ADP  A 400 ( 3.8A)
 0.72A 3bgdB-5fl3A:
2.3		 3bgdB-5fl3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 12 ALA A 224
ALA A 202
VAL A 138
ILE A 136
THR A 237
 None
 1.08A 3czhA-5fl3A:
undetectable		 3czhA-5fl3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 12 ALA A 224
ALA A 202
VAL A 138
ILE A 136
THR A 237
 None
 1.07A 3czhB-5fl3A:
undetectable		 3czhB-5fl3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 12 LEU A 266
LEU A 270
LEU A 137
THR A 246
ASN A 248
 None
 1.17A 3r9cA-5fl3A:
undetectable		 3r9cA-5fl3A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 12 ILE A 210
ALA A 227
ALA A 224
LEU A 135
ILE A 154
 None
 1.21A 3uvvB-5fl3A:
undetectable		 3uvvB-5fl3A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		3 / 3 ARG A 263
ARG A 260
ILE A 251
 None
 0.94A 4b7qA-5fl3A:
undetectable		 4b7qA-5fl3A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 12 ALA A 227
LEU A 266
GLY A 213
MET A 215
LEU A 238
 None
 1.13A 4kykA-5fl3A:
undetectable
4kykB-5fl3A:
undetectable		 4kykA-5fl3A:
19.02
4kykB-5fl3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		3 / 3 SER A  25
ARG A  38
HIS A  28
 ADP  A 400 ( 3.9A)
None
None
 0.97A 4mjwA-5fl3A:
undetectable
4mjwB-5fl3A:
undetectable		 4mjwA-5fl3A:
21.09
4mjwB-5fl3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		4 / 6 MET A 211
ILE A 295
ILE A 293
VAL A 124
 None
 0.97A 4olmA-5fl3A:
undetectable		 4olmA-5fl3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 12 GLU A 187
ASP A 191
GLU A 214
GLY A 198
ALA A 202
 None
 1.29A 4xe5A-5fl3A:
2.1		 4xe5A-5fl3A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		4 / 5 SER A 144
ARG A 216
GLY A 213
THR A 220
 ADP  A 400 (-4.6A)
None
None
None
 1.21A 5btiA-5fl3A:
undetectable
5btiB-5fl3A:
undetectable		 5btiA-5fl3A:
24.85
5btiB-5fl3A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 10 ILE A 250
ILE A 247
THR A 139
ASP A 242
ILE A 273
 None
 1.22A 5lg3F-5fl3A:
undetectable		 5lg3F-5fl3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 10 ILE A 250
ILE A 247
THR A 139
ASP A 242
ILE A 273
 None
 1.17A 5lg3G-5fl3A:
undetectable		 5lg3G-5fl3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 10 ILE A 250
ILE A 247
THR A 139
ASP A 242
ILE A 273
 None
 1.20A 5lg3H-5fl3A:
undetectable		 5lg3H-5fl3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fl3 PILI RETRACTION
PROTEIN PILT
(Thermus
thermophilus) 		5 / 12 ILE A 250
ILE A 247
THR A 139
ASP A 242
ILE A 273
 None
 1.21A 5lg3J-5fl3A:
undetectable		 5lg3J-5fl3A:
20.21