SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 6 LEU D 445
ILE D 375
ASP D 380
PRO D 381
None
1.20A 1ditH-5fl7D:
0.5
1ditP-5fl7D:
undetectable
1ditH-5fl7D:
18.07
1ditP-5fl7D:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica)
5 / 12 LEU D 382
ALA D 179
ALA D 362
GLN D 406
ARG A 388
None
1.25A 1kt4A-5fl7D:
undetectable
1kt4A-5fl7D:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
4 / 6 GLY A  98
GLN A  96
VAL A  57
ALA A  65
None
0.99A 1p6kA-5fl7A:
undetectable
1p6kA-5fl7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 8 ASP D 380
LEU D 348
ASP D 346
THR D 363
None
0.86A 1rmtD-5fl7D:
undetectable
1rmtD-5fl7D:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
4 / 5 TYR A 304
ALA A 266
TYR A 270
GLN A 156
None
1.12A 1xl6A-5fl7A:
undetectable
1xl6B-5fl7A:
undetectable
1xl6A-5fl7A:
21.10
1xl6B-5fl7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
3 / 3 MET A 409
ASN A 211
GLN A 456
None
1.02A 1xoqB-5fl7A:
undetectable
1xoqB-5fl7A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
4 / 7 ALA A 251
ASP A 250
GLY A 131
ILE A 256
None
0.74A 2fxdB-5fl7A:
undetectable
2fxdB-5fl7A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 12 LEU A 271
LEU A 268
MET A 307
VAL A 100
LEU A  90
None
1.31A 2q7kA-5fl7A:
undetectable
2q7kA-5fl7A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 6 LEU D 248
ILE D 238
ARG D 125
ILE D 126
ARG D 137
None
1.49A 2q8hA-5fl7D:
undetectable
2q8hA-5fl7D:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
4 / 8 SER A 396
THR A 372
PRO A 351
LEU A 297
None
1.10A 2v0zO-5fl7A:
undetectable
2v0zO-5fl7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
3 / 3 LEU D 409
TYR D 412
GLN D 416
None
0.75A 2wekA-5fl7D:
undetectable
2wekA-5fl7D:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 5 GLN D 313
THR D 315
HIS D 149
LEU D 265
None
1.38A 2zj0A-5fl7D:
undetectable
2zj0A-5fl7D:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 12 THR A 372
LEU A 332
ILE A 353
VAL A 232
PRO A 273
None
1.42A 3a51B-5fl7A:
undetectable
3a51B-5fl7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
4 / 6 THR A 174
GLN A 212
LEU A 350
LEU A 291
None
1.15A 3bgdA-5fl7A:
2.9
3bgdA-5fl7A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 4 GLU D 200
GLY D 168
THR D 167
GLU D 166
None
1.08A 3e9xA-5fl7D:
undetectable
3e9xA-5fl7D:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 8 VAL D 214
VAL D 118
ILE D 327
GLY D 267
None
0.95A 3hjoA-5fl7D:
undetectable
3hjoA-5fl7D:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA
ATP SYNTHASE SUBUNIT
GAMMA CHAIN,
MITOCHONDRIAL

(Yarrowia
lipolytica;
Yarrowia
lipolytica;
Yarrowia
lipolytica)
3 / 3 ASP D 347
ARG G  25
ARG A 197
None
1.03A 3k37A-5fl7D:
undetectable
3k37A-5fl7D:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 12 GLY D 119
GLY D 267
PHE D 215
LEU D 248
ALA D 271
None
1.09A 3kkzB-5fl7D:
undetectable
3kkzB-5fl7D:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 11 VAL A 468
PHE A 494
PHE A 530
GLY A 474
GLY A 477
None
1.37A 3owxA-5fl7A:
undetectable
3owxB-5fl7A:
undetectable
3owxA-5fl7A:
17.96
3owxB-5fl7A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 12 VAL A 412
ALA A 413
GLY A 414
ALA A 404
LEU A 515
None
1.18A 3qxyA-5fl7A:
undetectable
3qxyA-5fl7A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 11 VAL A 412
ALA A 413
GLY A 414
ALA A 404
LEU A 515
None
1.15A 3rc0A-5fl7A:
undetectable
3rc0A-5fl7A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 12 VAL A 412
ALA A 413
GLY A 414
ALA A 404
LEU A 515
None
1.14A 3rc0B-5fl7A:
undetectable
3rc0B-5fl7A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica)
4 / 6 ARG A 106
ASP D 109
ASN D  65
LYS A 109
None
1.19A 3wfaA-5fl7A:
undetectable
3wfaB-5fl7A:
undetectable
3wfaA-5fl7A:
23.06
3wfaB-5fl7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA
ATP SYNTHASE SUBUNIT
GAMMA CHAIN,
MITOCHONDRIAL

(Yarrowia
lipolytica;
Yarrowia
lipolytica)
4 / 5 LEU G 292
GLY D 304
ILE D  47
VAL D  50
None
0.80A 3wriA-5fl7G:
undetectable
3wriA-5fl7G:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA
ATP SYNTHASE SUBUNIT
GAMMA CHAIN,
MITOCHONDRIAL

(Yarrowia
lipolytica;
Yarrowia
lipolytica)
4 / 5 LEU G 292
GLY D 304
ILE D  47
VAL D  50
None
0.81A 3wriB-5fl7G:
undetectable
3wriB-5fl7G:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA
ATP SYNTHASE SUBUNIT
GAMMA CHAIN,
MITOCHONDRIAL

(Yarrowia
lipolytica;
Yarrowia
lipolytica)
4 / 5 LEU G 292
GLY D 304
ILE D  47
VAL D  50
None
0.83A 3wrkA-5fl7G:
undetectable
3wrkA-5fl7G:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
4 / 5 PHE A 294
LEU A 347
GLY A 280
VAL A 258
None
0.94A 3wrkD-5fl7A:
undetectable
3wrkD-5fl7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)
5fl7 ATP SYNTHASE DELTA
CHAIN, MITOCHONDRIAL

(Yarrowia
lipolytica)
4 / 6 VAL H  84
LEU H  50
ILE H  69
VAL H  28
None
0.92A 4a9kA-5fl7H:
undetectable
4a9kA-5fl7H:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 4 ASN D 404
SER D 386
LEU D 389
THR D 408
None
1.36A 4an2A-5fl7D:
undetectable
4an2A-5fl7D:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
4 / 6 MET A 338
GLY A 345
ARG A 165
GLU A 281
None
1.46A 4bqfA-5fl7A:
undetectable
4bqfA-5fl7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 10 VAL D 401
ASP D 477
SER D 471
PHE D 488
VAL D 405
None
1.24A 4eilD-5fl7D:
undetectable
4eilD-5fl7D:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 10 GLY A 474
GLY A 477
VAL A 468
PHE A 494
PHE A 530
None
1.39A 4fgkA-5fl7A:
undetectable
4fgkB-5fl7A:
undetectable
4fgkA-5fl7A:
17.96
4fgkB-5fl7A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 12 VAL D 401
ASP D 477
SER D 471
PHE D 488
VAL D 405
None
1.28A 4kyaB-5fl7D:
undetectable
4kyaB-5fl7D:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 10 VAL D 401
ASP D 477
SER D 471
PHE D 488
VAL D 405
None
1.34A 4kyaC-5fl7D:
undetectable
4kyaC-5fl7D:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 12 VAL D 401
ASP D 477
SER D 471
PHE D 488
VAL D 405
None
1.26A 4kyaD-5fl7D:
undetectable
4kyaD-5fl7D:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 12 VAL D 401
ASP D 477
SER D 471
PHE D 488
VAL D 405
None
1.23A 4kyaF-5fl7D:
undetectable
4kyaF-5fl7D:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 11 VAL D 401
ASP D 477
SER D 471
PHE D 488
VAL D 405
None
1.34A 4kyaG-5fl7D:
undetectable
4kyaG-5fl7D:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 12 VAL D 172
LEU D 462
GLY D 168
ASP D 173
ILE D 205
None
1.31A 4o5fA-5fl7D:
undetectable
4o5fB-5fl7D:
undetectable
4o5fA-5fl7D:
22.76
4o5fB-5fl7D:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 11 SER A 298
THR A 199
THR A 202
GLY A 195
THR A 355
None
ATP  A 600 (-4.9A)
MG  A 601 ( 2.8A)
None
None
1.45A 4qw3V-5fl7A:
undetectable
4qw3b-5fl7A:
undetectable
4qw3V-5fl7A:
19.84
4qw3b-5fl7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 11 SER A 298
THR A 199
THR A 202
GLY A 195
THR A 355
None
ATP  A 600 (-4.9A)
MG  A 601 ( 2.8A)
None
None
1.46A 4qw3H-5fl7A:
undetectable
4qw3N-5fl7A:
undetectable
4qw3H-5fl7A:
19.84
4qw3N-5fl7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 4 ILE D 205
ASN D 204
ILE D 169
VAL D 172
None
1.26A 4uy87-5fl7D:
undetectable
4uy87-5fl7D:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 11 ASP D 287
ALA D 340
ASP D 227
GLY D 219
GLY D 225
MG  D 601 ( 4.8A)
None
None
None
None
1.27A 4xp4A-5fl7D:
undetectable
4xp4A-5fl7D:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 12 ALA D 295
ASP D 287
GLU D 224
GLU D 220
THR D 195
None
MG  D 601 ( 4.8A)
MG  D 601 ( 3.8A)
MG  D 601 ( 4.9A)
MG  D 601 ( 3.1A)
1.48A 4zjoA-5fl7D:
undetectable
4zjoA-5fl7D:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 11 VAL A 468
PHE A 494
PHE A 530
GLY A 474
GLY A 477
None
1.34A 4zvmA-5fl7A:
undetectable
4zvmB-5fl7A:
undetectable
4zvmA-5fl7A:
18.05
4zvmB-5fl7A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
4 / 6 GLU A 379
GLY A 358
GLY A 357
ASP A 196
None
0.99A 5a06D-5fl7A:
undetectable
5a06D-5fl7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 12 VAL D 172
LEU D 462
GLY D 168
ASP D 173
ILE D 205
None
1.30A 5b8hA-5fl7D:
undetectable
5b8hB-5fl7D:
undetectable
5b8hA-5fl7D:
20.23
5b8hB-5fl7D:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 7 SER D 384
ASP D 346
ARG D 368
GLY D 369
None
0.72A 5btaA-5fl7D:
undetectable
5btaC-5fl7D:
undetectable
5btaD-5fl7D:
undetectable
5btaA-5fl7D:
23.82
5btaC-5fl7D:
23.82
5btaD-5fl7D:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 7 SER D 384
ASP D 346
ARG D 368
GLY D 369
None
0.78A 5btfA-5fl7D:
undetectable
5btfB-5fl7D:
1.6
5btfC-5fl7D:
undetectable
5btfA-5fl7D:
23.82
5btfB-5fl7D:
20.70
5btfC-5fl7D:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 11 SER A 298
THR A 199
THR A 202
GLY A 195
THR A 355
None
ATP  A 600 (-4.9A)
MG  A 601 ( 2.8A)
None
None
1.48A 5bxnV-5fl7A:
undetectable
5bxnb-5fl7A:
undetectable
5bxnV-5fl7A:
19.41
5bxnb-5fl7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
4 / 6 SER D 384
ASP D 346
ARG D 368
GLY D 369
None
0.80A 5cdqA-5fl7D:
undetectable
5cdqC-5fl7D:
undetectable
5cdqD-5fl7D:
undetectable
5cdqA-5fl7D:
24.57
5cdqC-5fl7D:
24.57
5cdqD-5fl7D:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
3 / 3 MET A 307
GLN A 306
ARG A 305
None
0.78A 5ewzB-5fl7A:
undetectable
5ewzB-5fl7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 12 LEU D 175
PRO D 177
ASP D 392
LEU D 174
ALA D 402
None
1.17A 5h5fA-5fl7D:
undetectable
5h5fA-5fl7D:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
3 / 3 MET A 307
GLN A 306
ARG A 305
None
0.78A 5m35B-5fl7A:
undetectable
5m35B-5fl7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
3 / 3 MET A 307
GLN A 306
ARG A 305
None
0.79A 5m36A-5fl7A:
undetectable
5m36A-5fl7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5fl7 ATP SYNTHASE DELTA
CHAIN, MITOCHONDRIAL

(Yarrowia
lipolytica)
4 / 4 GLU H  36
PRO H  31
ILE H  30
LEU H  37
None
1.17A 5m45J-5fl7H:
undetectable
5m45J-5fl7H:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica)
3 / 3 LYS A 385
LYS D 413
SER D 414
None
1.07A 5odiA-5fl7A:
undetectable
5odiA-5fl7A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
5 / 11 ARG A 152
GLY A 276
ALA A 278
ILE A 256
VAL A 258
None
1.11A 5yk2A-5fl7A:
undetectable
5yk2A-5fl7A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 10 LEU D 186
LEU D 360
ASP D 361
ILE D 198
SER D 337
None
1.24A 6dlzB-5fl7D:
4.2
6dlzC-5fl7D:
4.0
6dlzB-5fl7D:
9.77
6dlzC-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 11 ILE D 198
SER D 337
LEU D 186
LEU D 360
ASP D 361
None
1.25A 6dlzA-5fl7D:
3.0
6dlzD-5fl7D:
4.1
6dlzA-5fl7D:
9.77
6dlzD-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 10 LEU D 186
LEU D 360
ASP D 361
ILE D 198
SER D 337
None
1.22A 6dm0B-5fl7D:
4.0
6dm0C-5fl7D:
4.3
6dm0B-5fl7D:
9.77
6dm0C-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 10 LEU D 186
LEU D 360
ASP D 361
ILE D 198
SER D 337
None
1.24A 6dm1B-5fl7D:
4.1
6dm1C-5fl7D:
4.1
6dm1B-5fl7D:
9.77
6dm1C-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 11 ILE D 198
SER D 337
LEU D 186
LEU D 360
ASP D 361
None
1.24A 6dm1A-5fl7D:
4.2
6dm1D-5fl7D:
4.0
6dm1A-5fl7D:
9.77
6dm1D-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 10 LEU D 186
LEU D 360
ASP D 361
ILE D 198
SER D 337
None
1.24A 6dm2B-5fl7D:
2.6
6dm2C-5fl7D:
4.2
6dm2B-5fl7D:
9.77
6dm2C-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica)
5 / 10 ILE D 198
SER D 337
LEU D 186
LEU D 360
ASP D 361
None
1.25A 6dm2A-5fl7D:
4.2
6dm2D-5fl7D:
3.0
6dm2A-5fl7D:
9.77
6dm2D-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
3 / 3 MET A 307
GLN A 306
ARG A 305
None
0.81A 6fn9A-5fl7A:
undetectable
6fn9A-5fl7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
3 / 3 MET A 307
GLN A 306
ARG A 305
None
0.80A 6fnaB-5fl7A:
undetectable
6fnaB-5fl7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica)
3 / 3 MET A 307
GLN A 306
ARG A 305
None
0.82A 6fnbA-5fl7A:
undetectable
6fnbA-5fl7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica)
4 / 7 ASP D 390
ASP D 392
GLN A 458
GLN A 241
None
None
ATP  A 600 (-3.7A)
None
1.25A 6g31D-5fl7D:
undetectable
6g31D-5fl7D:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica)
4 / 6 ASP D 390
ASP D 392
GLN A 458
GLN A 241
None
None
ATP  A 600 (-3.7A)
None
1.28A 6g31J-5fl7D:
undetectable
6g31J-5fl7D:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica)
4 / 6 ASP D 390
ASP D 392
GLN A 458
GLN A 241
None
None
ATP  A 600 (-3.7A)
None
1.18A 6g31L-5fl7D:
undetectable
6g31L-5fl7D:
10.74