SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5flj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 12 HIS A 115
PHE A 141
PHE A  56
HIS A  71
HIS A  69
 NI  A 300 (-3.2A)
QUE  A 301 (-4.8A)
None
NI  A 300 ( 3.3A)
QUE  A 301 ( 3.0A)
 1.05A 1a4lA-5fljA:
undetectable		 1a4lA-5fljA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 12 HIS A 115
PHE A 141
PHE A  56
HIS A  71
HIS A  69
 NI  A 300 (-3.2A)
QUE  A 301 (-4.8A)
None
NI  A 300 ( 3.3A)
QUE  A 301 ( 3.0A)
 1.03A 1a4lC-5fljA:
undetectable		 1a4lC-5fljA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 7 PHE A 141
PHE A  56
VAL A 174
HIS A 115
 QUE  A 301 (-4.8A)
None
None
NI  A 300 (-3.2A)
 0.91A 1lh6A-5fljA:
undetectable		 1lh6A-5fljA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		3 / 3 GLU A  76
HIS A 115
HIS A  71
 NI  A 300 ( 2.3A)
NI  A 300 (-3.2A)
NI  A 300 ( 3.3A)
 0.60A 1oe2A-5fljA:
1.5		 1oe2A-5fljA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 11 TYR A 117
PHE A  78
PHE A 165
PHE A 137
VAL A 174
 QUE  A 301 (-4.8A)
QUE  A 301 (-3.9A)
None
QUE  A 301 ( 4.9A)
None
 1.29A 1q23J-5fljA:
undetectable		 1q23J-5fljA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 8 PHE A  36
GLU A  59
GLY A  60
THR A  41
 QUE  A 301 (-4.5A)
None
None
None
 0.90A 1ykiA-5fljA:
undetectable
1ykiB-5fljA:
undetectable		 1ykiA-5fljA:
25.32
1ykiB-5fljA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 8 THR A  41
PHE A  36
GLU A  59
GLY A  60
 None
QUE  A 301 (-4.5A)
None
None
 0.88A 1ykiA-5fljA:
undetectable
1ykiB-5fljA:
undetectable		 1ykiA-5fljA:
25.32
1ykiB-5fljA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 8 PHE A  36
GLU A  59
GLY A  60
THR A  41
 QUE  A 301 (-4.5A)
None
None
None
 0.89A 1ykiC-5fljA:
undetectable
1ykiD-5fljA:
undetectable		 1ykiC-5fljA:
25.32
1ykiD-5fljA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 8 THR A  41
PHE A  36
GLU A  59
GLY A  60
 None
QUE  A 301 (-4.5A)
None
None
 0.88A 1ykiC-5fljA:
undetectable
1ykiD-5fljA:
undetectable		 1ykiC-5fljA:
25.32
1ykiD-5fljA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 11 ALA A  33
PHE A 140
PHE A 141
ILE A  66
PRO A  67
 None
QUE  A 301 (-4.3A)
QUE  A 301 (-4.8A)
QUE  A 301 ( 4.0A)
None
 1.17A 2w3aA-5fljA:
undetectable		 2w3aA-5fljA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		3 / 3 ARG A  10
GLU A  47
TYR A  23
 None
 0.91A 3k37B-5fljA:
undetectable		 3k37B-5fljA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 12 PHE A  78
PHE A 176
VAL A 174
ALA A 130
PHE A 137
 QUE  A 301 (-3.9A)
QUE  A 301 (-4.4A)
None
QUE  A 301 ( 4.6A)
QUE  A 301 ( 4.9A)
 1.39A 3nhxA-5fljA:
undetectable		 3nhxA-5fljA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 12 THR A   7
SER A  13
GLU A  47
GLY A  46
GLY A  20
 None
 1.43A 4uinH-5fljA:
undetectable
4uinL-5fljA:
undetectable		 4uinH-5fljA:
23.01
4uinL-5fljA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		3 / 3 HIS A  69
HIS A 115
HIS A  71
 QUE  A 301 ( 3.0A)
NI  A 300 (-3.2A)
NI  A 300 ( 3.3A)
 0.51A 5zrdA-5fljA:
undetectable		 5zrdA-5fljA:
16.49