SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fll'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		5 / 12 MET A  12
GLY A  29
HIS A  26
ASP A 195
ASP A 196
 None
PPV  A 701 (-3.7A)
PPV  A 701 (-3.8A)
MG  A 704 (-2.7A)
MG  A 704 (-2.6A)
 1.40A 1a4lD-5fllA:
undetectable		 1a4lD-5fllA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		3 / 3 ASP A 198
HIS A  53
ASP A 195
 None
PPV  A 701 (-4.0A)
MG  A 704 (-2.7A)
 0.82A 1nw5A-5fllA:
undetectable		 1nw5A-5fllA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 8 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.14A 1p7lC-5fllA:
undetectable		 1p7lC-5fllA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 8 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.12A 1p7lD-5fllA:
undetectable		 1p7lD-5fllA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 8 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.13A 1rg9A-5fllA:
undetectable		 1rg9A-5fllA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 8 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.12A 1rg9B-5fllA:
undetectable		 1rg9B-5fllA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 8 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.12A 1rg9C-5fllA:
undetectable		 1rg9C-5fllA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 8 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.11A 1rg9D-5fllA:
undetectable		 1rg9D-5fllA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 7 ASP A 195
TYR A 199
ASP A 196
HIS A  26
 MG  A 704 (-2.7A)
WAQ  A 700 (-4.6A)
MG  A 704 (-2.6A)
PPV  A 701 (-3.8A)
 1.32A 1t03A-5fllA:
undetectable		 1t03A-5fllA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 5 ILE A 231
LEU A 127
ASP A 243
ALA A 186
 None
 0.79A 2opxA-5fllA:
undetectable		 2opxA-5fllA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		3 / 3 ASP A 198
TYR A 220
LYS A 218
 None
 1.13A 2othA-5fllA:
undetectable		 2othA-5fllA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		3 / 3 TRP A 119
VAL A 204
ARG A 213
 None
None
WAQ  A 700 (-3.8A)
 0.97A 3b0wA-5fllA:
undetectable		 3b0wA-5fllA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		5 / 12 LEU A  46
GLU A  66
VAL A  10
HIS A  26
GLY A 143
 None
None
None
PPV  A 701 (-3.8A)
None
 1.24A 4ydqA-5fllA:
undetectable		 4ydqA-5fllA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 8 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.06A 5t8sB-5fllA:
undetectable		 5t8sB-5fllA:
21.30