SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5flv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5flv HOMEOBOX PROTEIN
NKX-2.5, T-BOX
TRANSCRIPTION FACTOR
TBX5
(Mus
musculus) 		3 / 3 ARG A1134
SER A1086
TYR A1087
 None
 0.65A 1x70A-5flvA:
undetectable		 1x70A-5flvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5flv HOMEOBOX PROTEIN
NKX-2.5, T-BOX
TRANSCRIPTION FACTOR
TBX5
(Mus
musculus) 		3 / 3 PRO A1129
ASN A1174
HIS A1164
 None
 0.91A 4ma3H-5flvA:
undetectable
4ma3L-5flvA:
2.0		 4ma3H-5flvA:
21.57
4ma3L-5flvA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5flv HOMEOBOX PROTEIN
NKX-2.5, T-BOX
TRANSCRIPTION FACTOR
TBX5
(Mus
musculus) 		3 / 3 PRO A 165
ARG A 167
GLU A 166
 None
 0.83A 5j6hA-5flvA:
undetectable		 5j6hA-5flvA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5flv HOMEOBOX PROTEIN
NKX-2.5, T-BOX
TRANSCRIPTION FACTOR
TBX5
(Mus
musculus) 		4 / 7 THR A1203
ARG A1182
ASP A1105
LEU A1135
 None
 0.90A 5uxcA-5flvA:
undetectable		 5uxcA-5flvA:
20.63