SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		4 / 7 ALA A 243
ASP A 217
GLY A 212
THR A 221
 None
 0.64A 1t7iB-5flyA:
undetectable		 1t7iB-5flyA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		4 / 7 ALA A 243
ASP A 217
GLY A 212
THR A 221
 None
 0.63A 1t7jB-5flyA:
undetectable		 1t7jB-5flyA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		3 / 3 LYS A  68
ASP A 253
ASP A  54
 None
 0.99A 2br4D-5flyA:
2.2		 2br4D-5flyA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		4 / 6 SER A 179
GLU A 162
TYR A 169
GLN A  55
 None
7PG  A1295 ( 2.8A)
7PG  A1295 ( 3.5A)
None
 1.13A 2cl5B-5flyA:
undetectable		 2cl5B-5flyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		4 / 8 TYR A 111
ILE A 123
ILE A  19
PHE A 106
 None
 0.88A 3uqbA-5flyA:
undetectable		 3uqbA-5flyA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		4 / 6 GLU A   4
LYS A  23
PRO A  22
LYS A   3
 CD  A1283 (-3.0A)
CL  A1294 (-3.3A)
None
None
 1.34A 4a7tF-5flyA:
undetectable		 4a7tF-5flyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		4 / 8 PHE A 106
TYR A 108
GLY A  38
ASN A 260
 None
7PG  A1295 ( 3.3A)
None
7PG  A1295 ( 3.2A)
 0.89A 4qoiA-5flyA:
undetectable
4qoiB-5flyA:
undetectable		 4qoiA-5flyA:
22.79
4qoiB-5flyA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		3 / 3 LYS A 208
PRO A 207
LYS A 167
 CL  A1287 (-4.5A)
CL  A1290 (-4.7A)
None
 1.29A 5y9yA-5flyA:
undetectable		 5y9yA-5flyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		3 / 3 GLN A 184
TYR A 113
ASN A 174
 None
 0.96A 6dwdC-5flyA:
undetectable		 6dwdC-5flyA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		3 / 3 TRP A 133
GLU A 138
GLU A 118
 None
 0.99A 6fhwA-5flyA:
undetectable		 6fhwA-5flyA:
15.25