SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5flz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER C 378
SER C 271
TYR C 319
PHE C 316
 None
 1.27A 1eqbA-5flzC:
undetectable
1eqbB-5flzC:
undetectable		 1eqbA-5flzC:
22.00
1eqbB-5flzC:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 TYR C 319
PHE C 316
SER C 378
SER C 271
 None
 1.27A 1eqbA-5flzC:
undetectable
1eqbB-5flzC:
undetectable		 1eqbA-5flzC:
22.00
1eqbB-5flzC:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER C 378
SER C 271
TYR C 319
PHE C 316
 None
 1.27A 1eqbC-5flzC:
undetectable
1eqbD-5flzC:
undetectable		 1eqbC-5flzC:
22.00
1eqbD-5flzC:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 TYR C 319
PHE C 316
SER C 378
SER C 271
 None
 1.27A 1eqbC-5flzC:
undetectable
1eqbD-5flzC:
undetectable		 1eqbC-5flzC:
22.00
1eqbD-5flzC:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 114
ILE C 119
TRP C  93
 None
 0.94A 1m8eB-5flzC:
undetectable		 1m8eB-5flzC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 390
VAL A 394
CYH A 397
ALA A 401
 None
 0.85A 1mz9D-5flzA:
undetectable		 1mz9D-5flzA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 390
VAL A 394
CYH A 397
ALA A 401
 None
 0.90A 1mz9E-5flzA:
undetectable		 1mz9E-5flzA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 114
ILE C 119
TRP C  93
 None
 1.08A 1nodB-5flzC:
undetectable		 1nodB-5flzC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 11 PHE C 204
LEU C 139
VAL C  17
GLY C  18
ILE C 234
 None
 1.20A 1phgA-5flzC:
undetectable		 1phgA-5flzC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 114
ILE C 119
TRP C  93
 None
 1.09A 1qomA-5flzC:
undetectable		 1qomA-5flzC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  70
GLU A  71
THR A 120
TYR A 116
 None
 1.37A 1qvuA-5flzA:
2.5		 1qvuA-5flzA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 4 SER C 262
ILE C 260
VAL C 318
THR C 382
 None
 1.23A 1u70A-5flzC:
undetectable		 1u70A-5flzC:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 11 PHE C 204
VAL C  17
ILE C 234
THR C 239
LEU C 139
 None
 1.04A 1z11A-5flzC:
undetectable		 1z11A-5flzC:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 10 PHE C 204
VAL C  17
ILE C 234
THR C 239
LEU C 139
 None
 1.06A 1z11D-5flzC:
undetectable		 1z11D-5flzC:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 410
GLY B 353
LEU B 346
VAL B 431
ILE B 449
 None
 1.25A 1zq9A-5flzB:
undetectable		 1zq9A-5flzB:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 9 PHE C 204
LEU C 139
VAL C  17
GLY C  18
ILE C 234
 None
 1.33A 2a1oB-5flzC:
undetectable		 2a1oB-5flzC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 428
ILE A 425
ASN A 434
SER A 431
 None
 1.06A 2a8tB-5flzA:
undetectable		 2a8tB-5flzA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR C 170
THR C 169
GLY C 135
GLN C 137
GLU C 134
 None
 1.21A 2azxA-5flzC:
undetectable		 2azxA-5flzC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 363
LEU A 361
SER A 360
ARG A 358
 None
 0.82A 2byoA-5flzA:
undetectable		 2byoA-5flzA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 11 GLY C 151
SER C 148
ASN C  15
GLY C 145
GLN C  12
 None
 1.35A 2hmaA-5flzC:
undetectable		 2hmaA-5flzC:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 11 GLY C 151
SER C 148
ASN C  15
THR C 146
GLY C 145
 None
 1.33A 2hmaA-5flzC:
undetectable		 2hmaA-5flzC:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 114
ILE C 119
TRP C  93
 None
 1.05A 2nodB-5flzC:
undetectable		 2nodB-5flzC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR C 109
ALA C 190
GLY C 149
GLY C 145
ASN C 186
 None
 1.18A 2okcB-5flzC:
2.5		 2okcB-5flzC:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		3 / 3 SER B 737
HIS B 728
ASP B 722
 None
 0.67A 2oxtA-5flzB:
undetectable		 2oxtA-5flzB:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 185
GLU B 217
LEU B 221
TYR B 190
 None
 1.04A 2w8yA-5flzB:
undetectable		 2w8yA-5flzB:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 VAL C 397
ASN C 186
TRP C 105
 None
 1.07A 2y00B-5flzC:
undetectable		 2y00B-5flzC:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 110
GLY A 113
LYS A 114
ARG A 107
 None
 0.92A 3bjwA-5flzA:
undetectable		 3bjwA-5flzA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 114
ILE C 119
TRP C  93
 None
 0.88A 3e68A-5flzC:
undetectable		 3e68A-5flzC:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 114
ILE C 119
TRP C  93
 None
 0.95A 3e6tB-5flzC:
undetectable		 3e6tB-5flzC:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 114
ILE C 119
TRP C  93
 None
 1.10A 3e7iB-5flzC:
undetectable		 3e7iB-5flzC:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 452
ASP A 453
ILE A 484
GLN A 485
ASN A 454
 None
 1.14A 3eeyB-5flzA:
undetectable		 3eeyB-5flzA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 THR C 168
THR C 169
HIS C 140
ILE C   5
LEU C 194
 None
 1.07A 3gwxB-5flzC:
undetectable		 3gwxB-5flzC:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASN C 240
ASP C  47
ARG A 664
 None
 0.86A 3k13C-5flzC:
undetectable		 3k13C-5flzC:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 332
LEU A 344
CYH A 335
SER A 337
 None
 1.04A 3lm8B-5flzA:
undetectable
3lm8D-5flzA:
undetectable		 3lm8B-5flzA:
13.37
3lm8D-5flzA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 393
LEU A 390
LEU A 283
ASN A 379
 None
 1.05A 3lm8B-5flzA:
undetectable
3lm8D-5flzA:
undetectable		 3lm8B-5flzA:
13.37
3lm8D-5flzA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 332
LEU A 344
CYH A 335
SER A 337
 None
 0.96A 3lm8B-5flzA:
undetectable
3lm8D-5flzA:
undetectable		 3lm8B-5flzA:
13.37
3lm8D-5flzA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 ASN C 186
LEU C 150
GLY C 147
GLY C  11
ILE C 111
 None
 1.08A 3nk7A-5flzC:
undetectable		 3nk7A-5flzC:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 114
ILE C 119
TRP C  93
 None
 1.02A 3nw2A-5flzC:
undetectable		 3nw2A-5flzC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 114
ILE C 119
TRP C  93
 None
 1.11A 3nw2B-5flzC:
undetectable		 3nw2B-5flzC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 652
ILE B 656
ILE B 657
ILE B 586
 None
 0.88A 3p4wC-5flzB:
4.0		 3p4wC-5flzB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		5 / 11 VAL B 537
TYR B 562
LEU B 541
VAL B 473
ALA B 476
 None
 1.18A 3pghB-5flzB:
undetectable		 3pghB-5flzB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 590
GLN A 696
PHE A 700
LEU A 697
 None
 0.89A 3qeoB-5flzA:
undetectable		 3qeoB-5flzA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 PHE C  20
SER C 232
GLN C 229
 None
 0.94A 3smtA-5flzC:
undetectable		 3smtA-5flzC:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLN C  12
GLY C 147
GLY C 145
SER C 171
ALA C  10
 None
 1.34A 3t7sC-5flzC:
undetectable		 3t7sC-5flzC:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 6 GLU B 582
GLY B 579
LEU B 732
GLU B 725
 None
 0.97A 3w9tB-5flzB:
undetectable		 3w9tB-5flzB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 6 GLU B 582
GLY B 579
LEU B 732
GLU B 725
 None
 0.97A 3w9tE-5flzB:
undetectable		 3w9tE-5flzB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 6 GLU B 582
GLY B 579
LEU B 732
GLU B 725
 None
 0.98A 3w9tF-5flzB:
undetectable		 3w9tF-5flzB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 0.99A 4a97E-5flzB:
2.8		 4a97E-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 1.05A 4a97C-5flzB:
undetectable		 4a97C-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 1.07A 4a97D-5flzB:
2.8		 4a97D-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 0.97A 4a97G-5flzB:
1.3		 4a97G-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 0.98A 4a97H-5flzB:
1.3		 4a97H-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 187
VAL B 188
ILE B 224
GLU B 182
 None
 0.95A 4a97I-5flzB:
2.8		 4a97I-5flzB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLN C  38
SER C  42
ASN C  60
ILE C  31
ALA C  30
 None
 1.18A 4dx5B-5flzC:
undetectable		 4dx5B-5flzC:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 119
TYR A 116
LEU A 146
GLU A 147
 None
 1.20A 4f3tA-5flzA:
undetectable		 4f3tA-5flzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 593
TYR B 758
TYR B 652
 None
 1.10A 4ffwA-5flzB:
undetectable		 4ffwA-5flzB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 TYR C 445
ARG A 624
SER C 444
 None
 1.21A 4lf7I-5flzC:
undetectable
4lf7J-5flzC:
undetectable		 4lf7I-5flzC:
14.16
4lf7J-5flzC:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 TYR C 109
ARG C 193
SER C 152
 None
 1.15A 4lf7I-5flzC:
undetectable
4lf7J-5flzC:
undetectable		 4lf7I-5flzC:
14.16
4lf7J-5flzC:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 TYR C 445
ARG A 624
SER C 444
 None
 1.21A 4lf8I-5flzC:
undetectable
4lf8J-5flzC:
undetectable		 4lf8I-5flzC:
14.16
4lf8J-5flzC:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 TYR C 109
ARG C 193
SER C 152
 None
 1.15A 4lf8I-5flzC:
undetectable
4lf8J-5flzC:
undetectable		 4lf8I-5flzC:
14.16
4lf8J-5flzC:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 MET C  68
GLN C 137
TYR C 170
 None
 1.12A 4udcA-5flzC:
undetectable		 4udcA-5flzC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 5 THR C 273
GLY C 374
GLU C 327
HIS C 289
 None
 1.14A 5c0oH-5flzC:
undetectable		 5c0oH-5flzC:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 6 ALA C 200
THR C 168
VAL C 202
TYR C 170
 None
 1.01A 5eckA-5flzC:
1.2		 5eckA-5flzC:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 6 ALA C 200
THR C 168
VAL C 202
TYR C 170
 None
 0.98A 5eckD-5flzC:
undetectable		 5eckD-5flzC:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 5 HIS C  16
VAL C 172
GLY C 144
ALA C 143
 None
 0.99A 5hwaA-5flzC:
undetectable		 5hwaA-5flzC:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 412
VAL C 419
GLU C 422
ASN C 153
 None
 1.18A 5jh7C-5flzC:
42.5		 5jh7C-5flzC:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5flz SPINDLE POLE BODY
COMPONENT SPC98
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 652
ILE B 656
ILE B 657
ILE B 586
 None
 0.88A 5murB-5flzB:
4.0		 5murB-5flzB:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 149
ARG A 143
GLU A 147
LEU A 189
 None
 1.16A 5umwB-5flzA:
undetectable
5umwE-5flzA:
undetectable		 5umwB-5flzA:
5.72
5umwE-5flzA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 PHE C 267
VAL C 203
SER C 198
THR C 201
 None
 1.03A 5vkqA-5flzC:
undetectable
5vkqD-5flzC:
undetectable		 5vkqA-5flzC:
14.18
5vkqD-5flzC:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 SER C 198
THR C 201
PHE C 267
VAL C 203
 None
 1.07A 5vkqA-5flzC:
undetectable
5vkqB-5flzC:
undetectable		 5vkqA-5flzC:
14.18
5vkqB-5flzC:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER C 198
THR C 201
PHE C 267
VAL C 203
 None
 1.05A 5vkqB-5flzC:
undetectable
5vkqC-5flzC:
undetectable		 5vkqB-5flzC:
14.18
5vkqC-5flzC:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 SER C 198
THR C 201
PHE C 267
VAL C 203
 None
 1.07A 5vkqC-5flzC:
undetectable
5vkqD-5flzC:
undetectable		 5vkqC-5flzC:
14.18
5vkqD-5flzC:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL C 306
SER C 307
THR C 308
PHE C 387
LEU C 191
 None
 1.26A 6a93B-5flzC:
undetectable		 6a93B-5flzC:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 189
GLN A 115
LYS A 125
 None
 0.99A 6exiB-5flzA:
undetectable		 6exiB-5flzA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5flz SPINDLE POLE BODY
COMPONENT SPC97
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 189
GLN A 115
LYS A 125
 None
 0.99A 6exiA-5flzA:
undetectable		 6exiA-5flzA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5flz TUBULIN GAMMA CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 GLY C 112
LEU C 154
GLY C 151
LEU C 150
 None
 0.85A 6mdqA-5flzC:
undetectable		 6mdqA-5flzC:
10.68