SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fmf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		4 / 7 SER 1 381
SER 1 450
ALA 1 399
PHE 1 484
 None
 1.23A 1fxvA-5fmf1:
undetectable
1fxvB-5fmf1:
undetectable		 1fxvA-5fmf1:
17.15
1fxvB-5fmf1:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		5 / 11 LEU 1 708
LEU 1 594
HIS 1 598
LEU 1 739
ALA 1 555
 None
 1.09A 1h9zA-5fmf1:
undetectable		 1h9zA-5fmf1:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		5 / 11 LEU 1 708
LEU 1 594
HIS 1 598
LEU 1 739
ALA 1 555
 None
 1.06A 1ha2A-5fmf1:
undetectable		 1ha2A-5fmf1:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA,
TFA2
(Saccharomyces
cerevisiae) 		4 / 7 SER S 190
ASN S 222
ASP S 218
LYS S 216
 None
 1.32A 1hwiC-5fmfS:
undetectable		 1hwiC-5fmfS:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA,
TFA2
(Saccharomyces
cerevisiae) 		4 / 7 SER S 190
ASN S 222
ASP S 218
LYS S 216
 None
 1.32A 1hwiD-5fmfS:
undetectable		 1hwiD-5fmfS:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA,
TFA2
(Saccharomyces
cerevisiae) 		4 / 7 LEU S 163
GLU S 161
LYS S 127
ALA S 131
 None
 1.04A 1sn0B-5fmfS:
undetectable
1sn0D-5fmfS:
undetectable		 1sn0B-5fmfS:
20.13
1sn0D-5fmfS:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		5 / 9 LEU 1 708
LEU 1 594
HIS 1 598
LEU 1 739
ALA 1 555
 None
 0.98A 2bxeA-5fmf1:
undetectable		 2bxeA-5fmf1:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		5 / 10 LEU 1 708
LEU 1 594
HIS 1 598
LEU 1 739
ALA 1 555
 None
 0.97A 2bxeB-5fmf1:
undetectable		 2bxeB-5fmf1:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TFG1
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2
(Saccharomyces
cerevisiae) 		5 / 10 LEU V  61
LEU U 119
VAL U 137
ILE U 127
THR V 212
 None
 1.05A 2w9gA-5fmfV:
undetectable		 2w9gA-5fmfV:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TFG1
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2
(Saccharomyces
cerevisiae) 		5 / 10 LEU V  61
LEU U 119
VAL U 137
ILE U 127
THR V 212
 None
 1.14A 2w9hA-5fmfV:
undetectable		 2w9hA-5fmfV:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		3 / 3 SER 1 294
HIS 1 314
ASP 1 334
 None
 0.66A 2wa2B-5fmf1:
2.1		 2wa2B-5fmf1:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TFG1
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2
(Saccharomyces
cerevisiae) 		5 / 11 LEU V  61
LEU U 119
VAL U 137
ILE U 127
THR V 212
 None
 1.05A 3frbX-5fmfV:
undetectable		 3frbX-5fmfV:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT ALPHA,
TFA1
(Saccharomyces
cerevisiae) 		3 / 3 ARG R  65
LYS R  90
ARG R  62
 None
 1.47A 3w1wA-5fmfR:
undetectable
3w1wB-5fmfR:
undetectable		 3w1wA-5fmfR:
19.83
3w1wB-5fmfR:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT ALPHA,
TFA1
(Saccharomyces
cerevisiae) 		3 / 3 ARG R  62
ARG R  65
LYS R  90
 None
 1.43A 3w1wA-5fmfR:
undetectable
3w1wB-5fmfR:
undetectable		 3w1wA-5fmfR:
19.83
3w1wB-5fmfR:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA,
TFA2
(Saccharomyces
cerevisiae) 		3 / 3 ASP S 212
LYS S 208
ASP S 209
 None
 0.84A 4a7tA-5fmfS:
undetectable		 4a7tA-5fmfS:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		4 / 5 GLY 1 396
ILE 1 397
VAL 1 409
SER 1 450
 None
 1.10A 4d33A-5fmf1:
undetectable		 4d33A-5fmf1:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		4 / 5 GLY 1 396
ILE 1 397
VAL 1 409
SER 1 450
 None
 1.14A 4d33B-5fmf1:
undetectable		 4d33B-5fmf1:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		5 / 12 GLU 1 683
PHE 1 705
ASP 1 610
ASN 1 781
GLY 1 678
 None
 1.31A 4djeB-5fmf1:
undetectable		 4djeB-5fmf1:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		5 / 12 GLU 1 683
PHE 1 705
ASP 1 610
ASN 1 781
GLY 1 678
 None
 1.32A 4djfB-5fmf1:
undetectable		 4djfB-5fmf1:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5fmf TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2
(Saccharomyces
cerevisiae) 		3 / 3 LYS V 342
PRO V 344
LYS V 348
 None
 1.45A 4dr5L-5fmfV:
undetectable		 4dr5L-5fmfV:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5fmf TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2
(Saccharomyces
cerevisiae) 		3 / 3 LYS V 342
PRO V 344
LYS V 348
 None
 1.34A 4dr6L-5fmfV:
undetectable		 4dr6L-5fmfV:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA,
TFA2
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 PHE V 307
SER S 152
ARG V 352
VAL V 336
LEU V 303
 None
 1.37A 4k39A-5fmfV:
undetectable		 4k39A-5fmfV:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TFG1
(Saccharomyces
cerevisiae) 		3 / 3 SER U 417
ASP U 414
GLN U 150
 None
 0.90A 4oltA-5fmfU:
undetectable
4oltB-5fmfU:
undetectable		 4oltA-5fmfU:
21.12
4oltB-5fmfU:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		5 / 12 ALA 1 509
GLY 1 451
PHE 1 476
ASP 1 353
ALA 1 400
 None
 1.09A 4pclA-5fmf1:
3.4		 4pclA-5fmf1:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		5 / 12 ALA 1 399
MET 1 373
LEU 1 513
ILE 1 531
ILE 1 485
 None
 1.13A 4ptjA-5fmf1:
undetectable		 4ptjA-5fmf1:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		5 / 10 LEU 1 654
GLY 1 658
ASP 1 663
SER 1 661
ILE 1 606
 None
 1.08A 4xj7C-5fmf1:
undetectable
4xj7D-5fmf1:
undetectable		 4xj7C-5fmf1:
20.52
4xj7D-5fmf1:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5fmf RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 2, TFB2
RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 5, TFB5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 PHE W 491
LYS W 489
TYR W 459
ALA X   4
 None
 1.22A 4yshB-5fmfW:
undetectable		 4yshB-5fmfW:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TFG1
(Saccharomyces
cerevisiae) 		3 / 3 LYS U 142
ASP U 143
ARG U 145
 None
 0.93A 5jwaA-5fmfU:
undetectable
5jwaH-5fmfU:
undetectable		 5jwaA-5fmfU:
13.94
5jwaH-5fmfU:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		4 / 6 GLU 1 683
ARG 1 722
ARG 1 681
ARG 1 680
 None
 1.28A 5l6eA-5fmf1:
undetectable
5l6eB-5fmf1:
0.7		 5l6eA-5fmf1:
18.61
5l6eB-5fmf1:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TFG1
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 HIS U 117
TYR U 393
THR V 212
ARG V  63
LEU V  59
 None
 1.48A 5lsuB-5fmfU:
undetectable		 5lsuB-5fmfU:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		4 / 7 GLY 1 299
HIS 1 347
HIS 1 314
ASP 1 307
 None
 1.04A 5no9D-5fmf1:
undetectable		 5no9D-5fmf1:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		4 / 5 ALA 1 399
VAL 1 395
PHE 1 484
ILE 1 384
 None
 0.86A 5of1A-5fmf1:
undetectable		 5of1A-5fmf1:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		4 / 5 ALA 1 399
VAL 1 395
PHE 1 484
ILE 1 384
 None
 0.89A 5of1B-5fmf1:
undetectable		 5of1B-5fmf1:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TOA1
(Saccharomyces
cerevisiae) 		4 / 7 THR M  47
LEU M  46
THR M  52
VAL M   9
 None
 1.12A 5ov9A-5fmfM:
undetectable		 5ov9A-5fmfM:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TOA1
(Saccharomyces
cerevisiae) 		4 / 8 THR M  47
LEU M  46
THR M  52
VAL M   9
 None
 1.15A 5ov9B-5fmfM:
undetectable		 5ov9B-5fmfM:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5fmf RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 2, TFB2
RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 5, TFB5
(Saccharomyces
cerevisiae) 		4 / 6 TRP W 483
LEU X   9
GLU X  33
LEU W 458
 None
 1.42A 5xooA-5fmfW:
undetectable		 5xooA-5fmfW:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 5fmf DNA REPAIR HELICASE
RAD25, SSL2
(Saccharomyces
cerevisiae) 		3 / 3 VAL 1 313
TYR 1 335
GLU 1 305
 None
 0.81A 5zmqD-5fmf1:
undetectable
5zmqE-5fmf1:
undetectable		 5zmqD-5fmf1:
17.26
5zmqE-5fmf1:
7.83