SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5fml PA SUBUNIT OF
INFLUENZA B
POLYMERASE
PB2 SUBUNIT OF
INFLUENZA B
POLYMERASE
(Influenza
B
virus) 		4 / 7 GLY B  82
ILE A 755
THR B  12
LEU B  42
 None
 1.01A 2xrhA-5fmlB:
1.0		 2xrhA-5fmlB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5fml PA SUBUNIT OF
INFLUENZA B
POLYMERASE
(Influenza
B
virus) 		3 / 3 TYR B 150
VAL B  40
THR B 124
 None
 0.80A 2ygnA-5fmlB:
undetectable		 2ygnA-5fmlB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5fml PA SUBUNIT OF
INFLUENZA B
POLYMERASE
PB2 SUBUNIT OF
INFLUENZA B
POLYMERASE
(Influenza
B
virus) 		4 / 7 VAL B  79
ILE A 751
ILE A 755
GLN A 758
 None
 0.93A 3hgxA-5fmlB:
undetectable		 3hgxA-5fmlB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5fml PB2 SUBUNIT OF
INFLUENZA B
POLYMERASE
PA SUBUNIT OF
INFLUENZA B
POLYMERASE
(Influenza
B
virus;
Influenza
B
virus) 		4 / 5 VAL B  79
SER B  49
GLY A 754
ARG A 757
 None
 1.40A 3v4tA-5fmlB:
undetectable
3v4tD-5fmlB:
undetectable		 3v4tA-5fmlB:
17.95
3v4tD-5fmlB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5fml PA SUBUNIT OF
INFLUENZA B
POLYMERASE
PB2 SUBUNIT OF
INFLUENZA B
POLYMERASE
(Influenza
B
virus) 		4 / 5 VAL B 121
ILE A 755
TYR B  77
ILE A 751
 MG  B1195 (-4.1A)
None
None
None
 0.90A 4c8bA-5fmlB:
undetectable		 4c8bA-5fmlB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 5fml PA SUBUNIT OF
INFLUENZA B
POLYMERASE
PB2 SUBUNIT OF
INFLUENZA B
POLYMERASE
(Influenza
B
virus) 		5 / 12 TYR B  46
ALA B  88
GLY A 754
GLY B  82
THR A 761
 None
 0.94A 4mm8A-5fmlB:
undetectable		 4mm8A-5fmlB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5fml PA SUBUNIT OF
INFLUENZA B
POLYMERASE
(Influenza
B
virus) 		4 / 5 HIS B  41
VAL B  40
GLU B 193
VAL B 121
 MG  B1195 ( 3.5A)
None
None
MG  B1195 (-4.1A)
 1.37A 4p6vB-5fmlB:
undetectable
4p6vE-5fmlB:
undetectable		 4p6vB-5fmlB:
16.22
4p6vE-5fmlB:
19.91