SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fmq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		5 / 12 LEU A 298
MET A 315
ILE A 289
LEU A 513
VAL A 504
 None
 1.11A 1hrkA-5fmqA:
undetectable		 1hrkA-5fmqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 6 LEU A 599
VAL A 667
ILE A 647
ARG A 555
 None
 0.91A 1opjB-5fmqA:
undetectable		 1opjB-5fmqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		5 / 12 MET A 410
LEU A 445
GLN A 447
THR A 346
ILE A 411
 None
 1.45A 1p93A-5fmqA:
undetectable		 1p93A-5fmqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		5 / 12 ASP A 671
LEU A 665
ALA A 674
ILE A 553
PHE A 656
 None
 0.99A 2ejtA-5fmqA:
undetectable		 2ejtA-5fmqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		5 / 12 LEU A 298
MET A 315
ILE A 289
LEU A 513
VAL A 504
 None
 1.20A 2hrcB-5fmqA:
undetectable		 2hrcB-5fmqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		5 / 12 LEU A 298
MET A 315
ILE A 289
LEU A 513
VAL A 504
 None
 1.17A 2po5A-5fmqA:
undetectable		 2po5A-5fmqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 5 ASN A 510
ARG A 355
ASN A 429
HIS A 432
 MGT  A1676 (-3.5A)
MGT  A1676 (-3.4A)
MGT  A1676 (-3.6A)
None
 1.38A 3frqA-5fmqA:
1.0		 3frqA-5fmqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 4 LEU A 277
PRO A 276
LEU A 502
ARG A 505
 None
 1.38A 3hcoA-5fmqA:
undetectable		 3hcoA-5fmqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 7 VAL A 638
LEU A 546
TYR A 550
GLN A 581
 None
 0.96A 3qeoB-5fmqA:
undetectable		 3qeoB-5fmqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 5 ASP A 486
VAL A 485
GLY A 484
TYR A 488
 None
 1.32A 3w9tA-5fmqA:
undetectable		 3w9tA-5fmqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 5 ASP A 486
VAL A 485
GLY A 484
TYR A 488
 None
 1.31A 3w9tB-5fmqA:
undetectable		 3w9tB-5fmqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 5 ASP A 486
VAL A 485
GLY A 484
TYR A 488
 None
 1.31A 3w9tC-5fmqA:
undetectable		 3w9tC-5fmqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 5 ASP A 486
VAL A 485
GLY A 484
TYR A 488
 None
 1.31A 3w9tD-5fmqA:
undetectable		 3w9tD-5fmqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 5 ASP A 486
VAL A 485
GLY A 484
TYR A 488
 None
 1.31A 3w9tE-5fmqA:
undetectable		 3w9tE-5fmqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 5 ASP A 486
VAL A 485
GLY A 484
TYR A 488
 None
 1.30A 3w9tF-5fmqA:
undetectable		 3w9tF-5fmqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 5 ASP A 486
VAL A 485
GLY A 484
TYR A 488
 None
 1.31A 3w9tG-5fmqA:
undetectable		 3w9tG-5fmqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		3 / 3 ARG A 368
GLU A 520
ARG A 369
 None
 0.68A 4mwvA-5fmqA:
undetectable		 4mwvA-5fmqA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		5 / 9 GLN A 383
SER A 405
GLU A 407
ILE A 398
ALA A 397
 None
 1.27A 5entC-5fmqA:
undetectable		 5entC-5fmqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		3 / 3 ARG A 415
ASN A 448
ASP A 408
 None
 0.77A 5gwxA-5fmqA:
undetectable		 5gwxA-5fmqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 7 VAL A 485
GLU A 487
ILE A 398
VAL A 386
 None
 1.17A 5jh7C-5fmqA:
undetectable		 5jh7C-5fmqA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		4 / 6 ILE A 394
VAL A 478
VAL A 386
SER A 474
 None
 0.99A 5jwaH-5fmqA:
undetectable		 5jwaH-5fmqA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		5 / 10 TYR A 550
ILE A 553
ILE A 554
TRP A 557
TYR A 658
 None
 0.89A 5mvnD-5fmqA:
undetectable		 5mvnD-5fmqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 5fmq INFLUENZA A PB2
SUBUNIT
(Influenza
A
virus) 		3 / 3 LEU A 317
VAL A 295
ASP A 296
 None
 0.65A 5x23A-5fmqA:
undetectable		 5x23A-5fmqA:
22.74