SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fmr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52
(Chlamydomonas
reinhardtii) 		4 / 8 VAL A 180
ALA A 229
TRP A 235
PHE A 183
 None
 1.10A 1dmiA-5fmrA:
undetectable
1dmiB-5fmrA:
undetectable		 1dmiA-5fmrA:
21.33
1dmiB-5fmrA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A  91
PRO A 182
GLY A 141
LEU A 177
ILE A 142
 None
 1.07A 3ku1G-5fmrA:
2.1		 3ku1G-5fmrA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52
(Chlamydomonas
reinhardtii) 		5 / 11 ILE A  62
PHE A 248
PHE A 249
LEU A  34
VAL A  64
 None
 1.06A 3n0hA-5fmrA:
undetectable		 3n0hA-5fmrA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52
(Chlamydomonas
reinhardtii) 		5 / 12 ILE A  62
PHE A 248
PHE A 249
LEU A  34
VAL A  64
 None
 1.04A 3s3vA-5fmrA:
undetectable		 3s3vA-5fmrA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52
(Chlamydomonas
reinhardtii) 		4 / 5 PHE A 249
LEU A  93
GLY A  66
ILE A  15
 None
 0.85A 3wrkA-5fmrA:
undetectable		 3wrkA-5fmrA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52
(Chlamydomonas
reinhardtii) 		5 / 12 ILE A 222
GLY A  88
GLY A 220
ILE A  62
ALA A  60
 None
 1.11A 4kicB-5fmrA:
undetectable		 4kicB-5fmrA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52
(Chlamydomonas
reinhardtii) 		3 / 3 ARG A  36
HIS A  27
ARG A  39
 None
 1.15A 6dwdD-5fmrA:
undetectable		 6dwdD-5fmrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52
(Chlamydomonas
reinhardtii) 		3 / 3 ARG A 124
HIS A 127
ARG A 164
 SO4  A 903 (-4.0A)
SO4  A 903 (-3.7A)
SO4  A 903 (-3.2A)
 0.83A 6dwdD-5fmrA:
undetectable		 6dwdD-5fmrA:
20.22