SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		5 / 12 LEU A  84
VAL A 183
LEU A 198
ALA A 199
LEU A 241
 None
 1.24A 1jipA-5fmsA:
undetectable		 1jipA-5fmsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		4 / 4 SER A 216
VAL A 213
PHE A  95
VAL A  18
 None
 0.97A 1o86A-5fmsA:
undetectable		 1o86A-5fmsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		4 / 5 PHE A 238
LEU A 225
MET A  86
SER A 216
 None
 1.13A 1wrkB-5fmsA:
undetectable		 1wrkB-5fmsA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		5 / 12 MET A 219
GLY A  88
PHE A 170
ALA A 172
ASP A 113
 None
 1.49A 2avdA-5fmsA:
undetectable		 2avdA-5fmsA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		5 / 10 ALA A 212
MET A  86
GLY A 215
ILE A 197
VAL A 236
 None
 1.05A 3ogpA-5fmsA:
undetectable		 3ogpA-5fmsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		5 / 12 LEU A  28
LEU A 225
ARG A  33
ILE A  38
SER A 231
 None
 1.22A 4f4dB-5fmsA:
undetectable		 4f4dB-5fmsA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		4 / 7 PHE A 200
LYS A 210
TYR A 201
HIS A 202
 None
 1.44A 4uciB-5fmsA:
undetectable		 4uciB-5fmsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		4 / 6 LYS A  74
LEU A 103
GLU A 105
TYR A 106
 None
 1.17A 4z4cA-5fmsA:
undetectable		 4z4cA-5fmsA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		5 / 10 GLY A 215
GLY A  88
VAL A  85
CYH A 217
ILE A 108
 None
 1.17A 6exiA-5fmsA:
2.1		 6exiA-5fmsA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		5 / 10 GLY A 215
GLY A  88
VAL A  85
CYH A 217
ILE A 108
 None
 1.16A 6exiB-5fmsA:
2.2		 6exiB-5fmsA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		5 / 12 GLY A 215
GLY A  88
VAL A  85
CYH A 217
ILE A 108
 None
 1.15A 6exiC-5fmsA:
2.1
6exiD-5fmsA:
3.2		 6exiC-5fmsA:
18.64
6exiD-5fmsA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		5 / 12 GLY A 215
GLY A  88
VAL A  85
CYH A 217
ILE A 108
 None
 1.17A 6exiC-5fmsA:
2.2
6exiD-5fmsA:
3.2		 6exiC-5fmsA:
18.64
6exiD-5fmsA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG
(Mus
musculus) 		5 / 7 VAL A 237
LEU A 241
LEU A  55
LEU A 214
MET A  86
 None
 1.13A 6g9bA-5fmsA:
undetectable
6g9bB-5fmsA:
undetectable		 6g9bA-5fmsA:
17.12
6g9bB-5fmsA:
14.39