SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 5 LEU B  85
VAL B  89
CYH B  92
ALA B 231
 None
 1.16A 1mz9D-5fn3B:
undetectable		 1mz9D-5fn3B:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 1.02A 2dysP-5fn3B:
2.2
2dysW-5fn3B:
undetectable		 2dysP-5fn3B:
20.04
2dysW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 1.04A 2eimC-5fn3B:
2.1
2eimJ-5fn3B:
undetectable		 2eimC-5fn3B:
20.04
2eimJ-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.96A 2eimP-5fn3B:
2.2
2eimW-5fn3B:
undetectable		 2eimP-5fn3B:
20.04
2eimW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 1.01A 2einC-5fn3B:
2.1
2einJ-5fn3B:
undetectable		 2einC-5fn3B:
20.04
2einJ-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 6 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.93A 2einP-5fn3B:
2.1
2einW-5fn3B:
undetectable		 2einP-5fn3B:
20.04
2einW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		5 / 12 ILE B 229
TYR B 181
VAL B 185
LEU B 232
LEU B 201
 None
 1.23A 2rctA-5fn3B:
undetectable		 2rctA-5fn3B:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 6 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.95A 2zxwP-5fn3B:
2.1
2zxwW-5fn3B:
undetectable		 2zxwP-5fn3B:
20.04
2zxwW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 6 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.97A 3ag1C-5fn3B:
2.1
3ag1J-5fn3B:
undetectable		 3ag1C-5fn3B:
20.04
3ag1J-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.90A 3ag4P-5fn3B:
2.1
3ag4W-5fn3B:
undetectable		 3ag4P-5fn3B:
20.04
3ag4W-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.98A 3asnP-5fn3B:
2.1
3asnW-5fn3B:
undetectable		 3asnP-5fn3B:
20.04
3asnW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.96A 3asoP-5fn3B:
2.2
3asoW-5fn3B:
undetectable		 3asoP-5fn3B:
20.04
3asoW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		5 / 12 SER B 438
ILE B 439
LEU B 392
MET B  93
LEU B 381
 None
 1.35A 3cs8A-5fn3B:
undetectable		 3cs8A-5fn3B:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 6 THR B 440
GLY B 442
ILE B 414
LEU B 250
 None
 0.96A 4ac9C-5fn3B:
undetectable		 4ac9C-5fn3B:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 6 THR B 440
GLY B 442
ILE B 414
LEU B 250
 None
 0.91A 4acbC-5fn3B:
undetectable		 4acbC-5fn3B:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		5 / 12 ILE B 229
TYR B 181
VAL B 185
LEU B 232
LEU B 201
 None
 1.22A 4qynA-5fn3B:
undetectable		 4qynA-5fn3B:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 5 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.92A 5iy5P-5fn3B:
2.2
5iy5W-5fn3B:
undetectable		 5iy5P-5fn3B:
20.48
5iy5W-5fn3B:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		3 / 3 LYS B 101
GLN B 454
ASN B 405
 None
 1.09A 5l2tA-5fn3B:
undetectable		 5l2tA-5fn3B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 6 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 1.00A 5w97C-5fn3B:
undetectable
5w97J-5fn3B:
undetectable		 5w97C-5fn3B:
20.04
5w97J-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 5 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 1.00A 5x1fC-5fn3B:
2.1
5x1fJ-5fn3B:
undetectable		 5x1fC-5fn3B:
20.04
5x1fJ-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 5 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.96A 5xdxC-5fn3B:
2.2
5xdxJ-5fn3B:
undetectable		 5xdxC-5fn3B:
20.04
5xdxJ-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 5 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.99A 5xdxP-5fn3B:
2.1
5xdxW-5fn3B:
undetectable		 5xdxP-5fn3B:
20.04
5xdxW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.91A 5z85C-5fn3B:
2.2
5z85J-5fn3B:
undetectable		 5z85C-5fn3B:
20.04
5z85J-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.86A 5zcoC-5fn3B:
2.1
5zcoJ-5fn3B:
undetectable		 5zcoC-5fn3B:
20.04
5zcoJ-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.86A 5zcqC-5fn3B:
2.1
5zcqJ-5fn3B:
undetectable		 5zcqC-5fn3B:
20.04
5zcqJ-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		4 / 7 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.92A 5zcqP-5fn3B:
2.1
5zcqW-5fn3B:
undetectable		 5zcqP-5fn3B:
20.04
5zcqW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 5fn3 PRESENILIN-1
(Homo
sapiens) 		5 / 12 ILE B 387
VAL B 198
VAL B 185
VAL B  96
ALA B 234
 None
 1.42A 6a7pB-5fn3B:
undetectable		 6a7pB-5fn3B:
21.48