SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 5 LEU A 431
LEU A 427
LEU A 441
GLY A 438
 None
 0.83A 1a4lC-5fn4A:
undetectable		 1a4lC-5fn4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.08A 1c8lA-5fn4A:
undetectable		 1c8lA-5fn4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		4 / 6 LEU C 170
VAL C 220
VAL C 193
SER C 196
 None
 1.07A 1e7aB-5fn4C:
undetectable		 1e7aB-5fn4C:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.06A 1gfzA-5fn4A:
2.6		 1gfzA-5fn4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 10 ASN A 165
GLY A 366
ARG A 281
ASN A 450
PHE A 448
 None
 1.27A 1ho5B-5fn4A:
undetectable		 1ho5B-5fn4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 HIS A 553
LEU A 551
PHE A 525
VAL A 299
 None
 1.34A 1ibgH-5fn4A:
undetectable		 1ibgH-5fn4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.04A 1l5qA-5fn4A:
undetectable		 1l5qA-5fn4A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.04A 1l5qB-5fn4A:
undetectable		 1l5qB-5fn4A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.05A 1l7xA-5fn4A:
undetectable		 1l7xA-5fn4A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.04A 1l7xB-5fn4A:
undetectable		 1l7xB-5fn4A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		3 / 3 ARG C 186
ILE C 230
TRP C 227
 None
 1.12A 1m8eB-5fn4C:
undetectable		 1m8eB-5fn4C:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 4 THR A 483
LEU A 487
VAL A 490
LEU A 494
 None
 0.73A 1mz9D-5fn4A:
undetectable		 1mz9D-5fn4A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		3 / 3 ARG C 186
ILE C 230
TRP C 227
 None
 1.15A 1qomA-5fn4C:
undetectable		 1qomA-5fn4C:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 THR A 517
PRO A 515
THR A 519
 None
 0.81A 209dC-5fn4A:
undetectable		 209dC-5fn4A:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 12 ALA A 572
GLY A 576
GLY A 495
LEU A 312
LEU A 498
 None
 1.01A 2hw2A-5fn4A:
undetectable		 2hw2A-5fn4A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		4 / 8 LEU C  35
LEU C  43
VAL C 131
GLY C 130
 None
 1.01A 2po5A-5fn4C:
undetectable		 2po5A-5fn4C:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
NICASTRIN
(Homo
sapiens) 		4 / 4 LYS A 666
ALA C   4
PHE C   7
GLY C   8
 None
 1.44A 2rddA-5fn4A:
1.8		 2rddA-5fn4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 7 LEU A 637
GLU A 636
GLN A 355
ILE A 436
 None
 0.82A 2xkwA-5fn4A:
undetectable		 2xkwA-5fn4A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.03A 3dd1A-5fn4A:
2.9		 3dd1A-5fn4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.07A 3dd1B-5fn4A:
undetectable		 3dd1B-5fn4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.03A 3ddsA-5fn4A:
undetectable		 3ddsA-5fn4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.04A 3ddsB-5fn4A:
undetectable		 3ddsB-5fn4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.02A 3ddwA-5fn4A:
undetectable		 3ddwA-5fn4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 448
HIS A 449
ALA A 442
GLY A 366
 None
 1.05A 3ddwB-5fn4A:
undetectable		 3ddwB-5fn4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		3 / 3 ARG C 186
ILE C 230
TRP C 227
 None
 1.16A 3e68A-5fn4C:
undetectable		 3e68A-5fn4C:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		3 / 3 ARG C 186
ILE C 230
TRP C 227
 None
 1.11A 3e6tB-5fn4C:
undetectable		 3e6tB-5fn4C:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		3 / 3 ARG C 186
ILE C 230
TRP C 227
 None
 1.14A 3e7iB-5fn4C:
undetectable		 3e7iB-5fn4C:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 5 ASP A 443
ILE A 463
VAL A 303
THR A 492
 None
 0.79A 3eigA-5fn4A:
undetectable		 3eigA-5fn4A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 12 THR A 561
THR A 564
THR A 563
ILE A 338
LEU A 627
 None
 0.97A 3gwxA-5fn4A:
undetectable		 3gwxA-5fn4A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 10 LEU A  44
ILE A 192
PRO A 179
SER A  64
GLY A  71
 None
 1.47A 3hcpB-5fn4A:
3.4		 3hcpB-5fn4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 12 GLY A 332
THR A 564
GLU A 333
SER A 426
ILE A 338
 None
 1.20A 3id6C-5fn4A:
undetectable		 3id6C-5fn4A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
NICASTRIN
(Homo
sapiens) 		5 / 12 ILE A 690
VAL C 120
VAL C 176
SER C 113
ILE C 114
 None
 1.19A 3iw1A-5fn4A:
undetectable		 3iw1A-5fn4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5fn4 NICASTRIN
GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLU A 669
GLY C   8
ALA C   4
PHE C 157
ALA C 161
 None
 1.30A 3nmuA-5fn4A:
undetectable
3nmuF-5fn4A:
undetectable		 3nmuA-5fn4A:
20.88
3nmuF-5fn4A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5fn4 NICASTRIN
GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLU A 669
GLY C   8
ALA C   4
PHE C 157
ALA C 161
 None
 1.21A 3nvkF-5fn4A:
undetectable
3nvkJ-5fn4A:
undetectable		 3nvkF-5fn4A:
20.95
3nvkJ-5fn4A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0Q_B_ADNB1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 9 ASN A 450
SER A 135
ASP A 458
PRO A 424
THR A 334
 None
 1.45A 3o0qB-5fn4A:
3.1		 3o0qB-5fn4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		5 / 12 ILE C 168
SER C 129
ILE C 137
ALA C 141
PHE C  14
 None
 1.21A 3vw1B-5fn4C:
3.8		 3vw1B-5fn4C:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		5 / 12 ILE C 168
SER C 129
ILE C 137
ALA C 141
PHE C  14
 None
 1.26A 3vw1D-5fn4C:
3.8		 3vw1D-5fn4C:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 ASN A 450
ASP A 458
ASN A 462
 None
 0.52A 4agaA-5fn4A:
undetectable		 4agaA-5fn4A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		5 / 12 PHE C 125
HIS C 171
ALA C  89
HIS C 197
SER C 201
 None
 1.40A 4aqlA-5fn4C:
undetectable		 4aqlA-5fn4C:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 GLY A 446
SER A 445
TRP A 377
 None
 0.94A 4e7cD-5fn4A:
undetectable		 4e7cD-5fn4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 8 PHE A 103
PHE A 134
ASN A 169
ALA A 172
 None
 0.92A 4ejgB-5fn4A:
undetectable		 4ejgB-5fn4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 6 PHE A 103
PHE A 134
ASN A 169
ALA A 172
 None
 0.99A 4ejgD-5fn4A:
undetectable		 4ejgD-5fn4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 8 LEU A 498
THR A 304
ALA A 308
LEU A 312
 None
 0.90A 4ik6B-5fn4A:
undetectable		 4ik6B-5fn4A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 12 ARG A 117
TYR A  94
GLY A  89
PHE A 210
LEU A 212
 None
 1.02A 4kosA-5fn4A:
undetectable		 4kosA-5fn4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 12 ARG A 117
TYR A  94
GLY A  89
PHE A 210
LEU A 212
 None
 1.08A 4kotA-5fn4A:
undetectable		 4kotA-5fn4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 10 ARG A 117
TYR A  94
GLY A  89
PHE A 210
LEU A 212
 None
 1.10A 4kouA-5fn4A:
undetectable		 4kouA-5fn4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 12 ARG A 117
TYR A  94
GLY A  89
PHE A 210
LEU A 212
 None
 1.05A 4kovA-5fn4A:
undetectable		 4kovA-5fn4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 12 ARG A 117
TYR A  94
GLY A  89
PHE A 210
LEU A 212
 None
 1.03A 4kowA-5fn4A:
undetectable		 4kowA-5fn4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 5 TYR A 453
GLN A 367
SER A 301
ASP A 283
 None
 1.44A 4qtuB-5fn4A:
undetectable		 4qtuB-5fn4A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 7 PRO A 208
SER A 665
GLU A 667
THR A 674
 None
 1.15A 4uacA-5fn4A:
2.4		 4uacA-5fn4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 12 LEU A 312
LEU A 494
THR A 280
ALA A 278
VAL A 276
 None
 0.90A 4x1yD-5fn4A:
undetectable		 4x1yD-5fn4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 11 LEU A 312
LEU A 494
THR A 280
ALA A 278
VAL A 276
 None
 0.87A 4x20D-5fn4A:
4.3		 4x20D-5fn4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 10 GLY A 495
GLU A 500
VAL A 493
LEU A 501
LEU A 413
 None
 1.26A 4yb6A-5fn4A:
undetectable
4yb6E-5fn4A:
undetectable		 4yb6A-5fn4A:
19.32
4yb6E-5fn4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 10 GLY A 495
GLU A 500
VAL A 493
LEU A 501
LEU A 413
 None
 1.28A 4yb6B-5fn4A:
undetectable
4yb6C-5fn4A:
undetectable		 4yb6B-5fn4A:
19.32
4yb6C-5fn4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 10 GLY A 495
GLU A 500
VAL A 493
LEU A 501
LEU A 413
 None
 1.28A 4yb6C-5fn4A:
undetectable
4yb6F-5fn4A:
undetectable		 4yb6C-5fn4A:
19.32
4yb6F-5fn4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 10 LEU A 501
LEU A 413
GLY A 495
GLU A 500
VAL A 493
 None
 1.29A 4yb6A-5fn4A:
undetectable
4yb6D-5fn4A:
undetectable		 4yb6A-5fn4A:
19.32
4yb6D-5fn4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 10 LEU A 501
LEU A 413
GLY A 495
GLU A 500
VAL A 493
 None
 1.28A 4yb6D-5fn4A:
undetectable
4yb6E-5fn4A:
undetectable		 4yb6D-5fn4A:
19.32
4yb6E-5fn4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 10 LEU A 501
LEU A 413
GLY A 495
GLU A 500
VAL A 493
 None
 1.28A 4yb6B-5fn4A:
undetectable
4yb6F-5fn4A:
undetectable		 4yb6B-5fn4A:
19.32
4yb6F-5fn4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 11 SER A 301
ALA A 447
ASP A 458
GLU A 296
GLY A 294
 None
 1.28A 4zjoD-5fn4A:
undetectable		 4zjoD-5fn4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 12 GLY A 146
GLY A 144
THR A 647
GLU A 644
ILE A 338
 None
 1.04A 5ehiA-5fn4A:
undetectable		 5ehiA-5fn4A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 9 SER A 340
GLY A 332
ALA A 298
GLU A 364
ILE A 555
 None
 1.26A 5i3cA-5fn4A:
5.8		 5i3cA-5fn4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5fn4 NICASTRIN
(Homo
sapiens) 		5 / 11 SER A 340
GLY A 332
ALA A 298
GLU A 364
ILE A 555
 None
 1.21A 5i3cC-5fn4A:
6.4		 5i3cC-5fn4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fn4 NICASTRIN
(Homo
sapiens) 		4 / 5 GLY A 576
THR A 577
GLY A 549
LEU A 538
 None
 0.81A 5jlcA-5fn4A:
0.7		 5jlcA-5fn4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		4 / 8 HIS C 197
HIS C 171
GLY C 126
SER C 129
 None
 0.98A 5m8rC-5fn4C:
undetectable		 5m8rC-5fn4C:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
NICASTRIN
(Homo
sapiens) 		5 / 12 GLY C   2
GLU A 667
GLU A 669
LEU A 670
LEU A 673
 None
 0.89A 5nwvA-5fn4C:
undetectable		 5nwvA-5fn4C:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 VAL A 275
VAL A 359
GLN A 355
 None
 0.59A 5qgjA-5fn4A:
undetectable		 5qgjA-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 VAL A 275
VAL A 359
GLN A 355
 None
 0.64A 5qgmA-5fn4A:
undetectable		 5qgmA-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 VAL A 275
VAL A 359
GLN A 355
 None
 0.59A 5qgnA-5fn4A:
undetectable		 5qgnA-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 VAL A 275
VAL A 359
GLN A 355
 None
 0.68A 5qgzA-5fn4A:
undetectable		 5qgzA-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 VAL A 275
VAL A 359
GLN A 355
 None
 0.67A 5qh3A-5fn4A:
undetectable		 5qh3A-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 VAL A 275
VAL A 359
GLN A 355
 None
 0.63A 5qh5A-5fn4A:
undetectable		 5qh5A-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 VAL A 275
VAL A 359
GLN A 355
 None
 0.66A 5qh6A-5fn4A:
undetectable		 5qh6A-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 VAL A 275
VAL A 359
GLN A 355
 None
 0.65A 5qh7A-5fn4A:
undetectable		 5qh7A-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5fn4 NICASTRIN
(Homo
sapiens) 		3 / 3 VAL A 275
VAL A 359
GLN A 355
 None
 0.65A 5qhhA-5fn4A:
undetectable		 5qhhA-5fn4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens) 		4 / 8 TRP C 188
ARG C 184
VAL C 177
ASP C 180
 None
 0.85A 5vlmA-5fn4C:
1.2		 5vlmA-5fn4C:
20.91