SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fn6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5fn6 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C
(Homo
sapiens) 		4 / 6 ASN A 253
ILE A 247
ASN A 219
THR A 206
 NAG  A1269 (-1.8A)
None
NAG  A1265 (-4.0A)
NAG  A1269 (-3.0A)
 1.26A 1h7xB-5fn6A:
undetectable		 1h7xB-5fn6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5fn6 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C
(Homo
sapiens) 		4 / 6 ASN A 253
ILE A 247
ASN A 219
THR A 206
 NAG  A1269 (-1.8A)
None
NAG  A1265 (-4.0A)
NAG  A1269 (-3.0A)
 1.27A 1h7xC-5fn6A:
undetectable		 1h7xC-5fn6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5fn6 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C
(Homo
sapiens) 		4 / 6 ASN A 253
ILE A 247
ASN A 219
THR A 206
 NAG  A1269 (-1.8A)
None
NAG  A1265 (-4.0A)
NAG  A1269 (-3.0A)
 1.27A 1h7xD-5fn6A:
undetectable		 1h7xD-5fn6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5fn6 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C
(Homo
sapiens) 		5 / 9 ALA A 244
LEU A 242
LEU A 220
ASN A 219
ILE A 193
 None
None
None
NAG  A1265 (-4.0A)
None
 1.44A 3wdmA-5fn6A:
undetectable		 3wdmA-5fn6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5fn6 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C
(Homo
sapiens) 		4 / 8 ILE A  18
TYR A  22
VAL A  64
ASP A  12
 None
 0.96A 5vlmF-5fn6A:
undetectable		 5vlmF-5fn6A:
18.98