SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 11 HIS A 160
GLU A 165
LEU A 166
GLU A 125
HIS A 129
 ZN  A1221 (-3.3A)
None
None
None
ZN  A1221 ( 3.2A)
 1.41A 1mjqA-5fnpA:
undetectable
1mjqB-5fnpA:
undetectable		 1mjqA-5fnpA:
16.43
1mjqB-5fnpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 10 HIS A 160
GLU A 165
LEU A 166
GLU A 125
HIS A 129
 ZN  A1221 (-3.3A)
None
None
None
ZN  A1221 ( 3.2A)
 1.42A 1mjqG-5fnpA:
undetectable
1mjqH-5fnpA:
undetectable		 1mjqG-5fnpA:
16.43
1mjqH-5fnpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		4 / 7 GLU A 133
GLU A 208
ILE A  79
LEU A 126
 ZN  A1221 (-2.3A)
ZN  A1222 (-2.2A)
ZN  A1222 ( 4.9A)
None
 1.46A 1q0yH-5fnpA:
undetectable
1q0yL-5fnpA:
undetectable		 1q0yH-5fnpA:
20.31
1q0yL-5fnpA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 10 ALA A 216
GLU A 220
LEU A  72
ILE A  79
LEU A 137
 None
None
None
ZN  A1222 ( 4.9A)
None
 1.23A 1qkuA-5fnpA:
undetectable		 1qkuA-5fnpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 10 ALA A 216
GLU A 220
LEU A  72
ILE A  79
LEU A 137
 None
None
None
ZN  A1222 ( 4.9A)
None
 1.23A 1qkuB-5fnpA:
undetectable		 1qkuB-5fnpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 10 ALA A 216
GLU A 220
LEU A  72
ILE A  79
LEU A 137
 None
None
None
ZN  A1222 ( 4.9A)
None
 1.23A 1qkuC-5fnpA:
undetectable		 1qkuC-5fnpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		4 / 6 ARG A  82
GLU A 208
ASN A 210
ALA A  30
 None
ZN  A1222 (-2.2A)
None
None
 1.37A 2ejfB-5fnpA:
undetectable		 2ejfB-5fnpA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 11 HIS A 204
ILE A  79
HIS A  84
HIS A 129
HIS A 160
 ZN  A1222 ( 3.3A)
ZN  A1222 ( 4.9A)
ZN  A1222 ( 3.3A)
ZN  A1221 ( 3.2A)
ZN  A1221 (-3.3A)
 1.31A 2zwgA-5fnpA:
undetectable
2zwgB-5fnpA:
undetectable		 2zwgA-5fnpA:
22.11
2zwgB-5fnpA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		4 / 7 LEU A  94
VAL A 101
TYR A 191
LEU A 115
 None
 1.07A 4b3qA-5fnpA:
undetectable		 4b3qA-5fnpA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 10 GLN A  97
ALA A  98
THR A 173
VAL A 169
LEU A 166
 None
 1.19A 4j6cB-5fnpA:
undetectable		 4j6cB-5fnpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 12 HIS A  84
HIS A 204
PHE A 213
GLU A 208
LEU A 217
 ZN  A1222 ( 3.3A)
ZN  A1222 ( 3.3A)
None
ZN  A1222 (-2.2A)
None
 1.39A 4r7lA-5fnpA:
undetectable		 4r7lA-5fnpA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		4 / 6 LEU A 167
LEU A 166
LEU A  91
HIS A 204
 None
None
None
ZN  A1222 ( 3.3A)
 0.98A 5gs4A-5fnpA:
2.8		 5gs4A-5fnpA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		4 / 4 GLU A  93
PRO A  92
ILE A  95
LEU A  94
 None
 1.10A 5m45A-5fnpA:
undetectable		 5m45A-5fnpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		4 / 4 GLU A  93
PRO A  92
ILE A  95
LEU A  94
 None
 1.16A 5m45D-5fnpA:
undetectable		 5m45D-5fnpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		4 / 4 GLU A  93
PRO A  92
ILE A  95
LEU A  94
 None
 1.08A 5m45G-5fnpA:
undetectable		 5m45G-5fnpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		4 / 4 GLU A  93
PRO A  92
ILE A  95
LEU A  94
 None
 1.16A 5m45J-5fnpA:
0.6		 5m45J-5fnpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 11 HIS A 204
ILE A  79
HIS A  84
HIS A 129
HIS A 160
 ZN  A1222 ( 3.3A)
ZN  A1222 ( 4.9A)
ZN  A1222 ( 3.3A)
ZN  A1221 ( 3.2A)
ZN  A1221 (-3.3A)
 1.31A 5z0kA-5fnpA:
undetectable
5z0kB-5fnpA:
undetectable		 5z0kA-5fnpA:
20.75
5z0kB-5fnpA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 11 HIS A 204
ILE A  79
HIS A  84
HIS A 129
HIS A 160
 ZN  A1222 ( 3.3A)
ZN  A1222 ( 4.9A)
ZN  A1222 ( 3.3A)
ZN  A1221 ( 3.2A)
ZN  A1221 (-3.3A)
 1.30A 5z0lA-5fnpA:
undetectable
5z0lB-5fnpA:
undetectable		 5z0lA-5fnpA:
20.75
5z0lB-5fnpA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 11 HIS A 204
ILE A  79
HIS A  84
HIS A 129
HIS A 160
 ZN  A1222 ( 3.3A)
ZN  A1222 ( 4.9A)
ZN  A1222 ( 3.3A)
ZN  A1221 ( 3.2A)
ZN  A1221 (-3.3A)
 1.36A 5z0mA-5fnpA:
undetectable
5z0mB-5fnpA:
undetectable		 5z0mA-5fnpA:
20.75
5z0mB-5fnpA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE
(Escherichia
coli) 		5 / 11 ILE A 194
THR A  99
MET A 121
THR A 120
LEU A 166
 None
 1.36A 6hupA-5fnpA:
undetectable
6hupB-5fnpA:
4.1		 6hupA-5fnpA:
14.98
6hupB-5fnpA:
15.64