SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fnu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 HIS A 437
GLY A 430
ASN A 414
GLY A 378
MET A 456
 None
None
CL  A1616 (-3.5A)
None
None
 1.25A 1ffyA-5fnuA:
undetectable		 1ffyA-5fnuA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 6 ARG A 507
ASP A 589
ASP A 587
GLU A 535
 None
 1.33A 1rjdA-5fnuA:
undetectable		 1rjdA-5fnuA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 6 ARG A 507
ASP A 589
ASP A 587
GLU A 535
 None
 1.32A 1rjdB-5fnuA:
undetectable		 1rjdB-5fnuA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 5 ALA A 331
TYR A 329
ALA A 376
TYR A 396
 None
 1.12A 1xl6A-5fnuA:
undetectable
1xl6B-5fnuA:
undetectable		 1xl6A-5fnuA:
21.70
1xl6B-5fnuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 HIS A 437
SER A 439
GLY A 417
VAL A 377
ALA A 376
 None
 1.17A 2kceB-5fnuA:
undetectable		 2kceB-5fnuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 4 ALA A 331
TYR A 329
ALA A 376
TYR A 396
 None
 1.10A 2wlkA-5fnuA:
undetectable
2wlkB-5fnuA:
undetectable		 2wlkA-5fnuA:
21.70
2wlkB-5fnuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 THR A 560
ILE A 328
TYR A 329
HIS A 562
PRO A 347
 None
 1.26A 2y7kC-5fnuA:
undetectable		 2y7kC-5fnuA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
 1.26A 3bwmA-5fnuA:
undetectable		 3bwmA-5fnuA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
 1.26A 3bwyA-5fnuA:
undetectable		 3bwyA-5fnuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 ALA A 376
GLY A 603
SER A 363
GLY A 379
GLY A 378
 None
L6I  A1615 (-3.3A)
L6I  A1615 (-2.9A)
None
None
 0.92A 3douA-5fnuA:
undetectable		 3douA-5fnuA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 GLY A 574
VAL A 568
GLY A 571
SER A 555
ALA A 522
 None
None
None
L6I  A1615 (-2.7A)
None
 1.12A 3keeB-5fnuA:
undetectable		 3keeB-5fnuA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 LEU A 342
GLY A 367
VAL A 420
GLY A 417
ILE A 416
 None
 0.79A 3ku1H-5fnuA:
undetectable		 3ku1H-5fnuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 5 GLY A 379
ASP A 389
ARG A 415
GLN A 337
 None
None
L6I  A1615 (-4.0A)
None
 1.46A 3qx3A-5fnuA:
undetectable		 3qx3A-5fnuA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 GLY A 378
GLY A 379
SER A 431
ALA A 427
VAL A 465
 None
 0.97A 4htfA-5fnuA:
undetectable		 4htfA-5fnuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 GLY A 378
GLY A 379
SER A 431
ALA A 427
VAL A 465
 None
 0.94A 4htfB-5fnuA:
undetectable		 4htfB-5fnuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 GLY A 605
GLY A 462
GLY A 603
VAL A 377
ILE A 416
 None
L6I  A1615 ( 3.2A)
L6I  A1615 (-3.3A)
None
None
 1.00A 4q5mA-5fnuA:
undetectable		 4q5mA-5fnuA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 ALA A 556
GLY A 524
ILE A 519
ALA A 466
GLY A 464
 L6I  A1615 (-2.9A)
None
None
None
None
 1.06A 4r29D-5fnuA:
undetectable		 4r29D-5fnuA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
 1.26A 4xucA-5fnuA:
undetectable		 4xucA-5fnuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
 1.48A 4xucA-5fnuA:
undetectable		 4xucA-5fnuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
 1.22A 4xudA-5fnuA:
undetectable		 4xudA-5fnuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
 1.25A 4xueB-5fnuA:
undetectable		 4xueB-5fnuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		3 / 3 ALA A 376
TYR A 375
PRO A 398
 None
 0.62A 4zdyA-5fnuA:
undetectable		 4zdyA-5fnuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		3 / 3 ALA A 427
TYR A 426
PRO A 445
 None
 0.66A 4zdyA-5fnuA:
undetectable		 4zdyA-5fnuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		3 / 3 ALA A 474
TYR A 473
PRO A 492
 None
 0.60A 4zdyA-5fnuA:
undetectable		 4zdyA-5fnuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 ALA A 522
GLY A 558
GLY A 511
GLY A 509
LEU A 569
 None
None
None
L6I  A1615 (-3.0A)
None
 1.06A 5c0oE-5fnuA:
undetectable		 5c0oE-5fnuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 ALA A 522
GLY A 558
GLY A 511
GLY A 509
LEU A 569
 None
None
None
L6I  A1615 (-3.0A)
None
 0.91A 5c0oH-5fnuA:
undetectable		 5c0oH-5fnuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 GLY A 605
LEU A 557
LEU A 358
GLY A 379
GLY A 509
 None
None
None
None
L6I  A1615 (-3.0A)
 1.10A 5d4uB-5fnuA:
undetectable		 5d4uB-5fnuA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 4 LEU A 365
GLY A 364
SER A 363
SER A 338
 None
L6I  A1615 (-3.1A)
L6I  A1615 (-2.9A)
None
 1.22A 5uunB-5fnuA:
undetectable		 5uunB-5fnuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		3 / 3 TYR A 396
ALA A 344
TYR A 329
 None
 0.60A 5uunB-5fnuA:
undetectable		 5uunB-5fnuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 9 GLY A 603
ALA A 556
GLY A 333
LEU A 339
SER A 338
 L6I  A1615 (-3.3A)
L6I  A1615 (-2.9A)
None
None
None
 1.24A 5vw4A-5fnuA:
undetectable		 5vw4A-5fnuA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 8 PRO A 398
THR A 609
TYR A 329
PRO A 445
 None
 1.11A 5x2sI-5fnuA:
undetectable
5x2sJ-5fnuA:
undetectable
5x2sK-5fnuA:
undetectable		 5x2sI-5fnuA:
17.18
5x2sJ-5fnuA:
18.18
5x2sK-5fnuA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 7 VAL A 428
VAL A 377
GLY A 419
TYR A 426
 None
 0.88A 5x80C-5fnuA:
undetectable
5x80D-5fnuA:
undetectable		 5x80C-5fnuA:
19.61
5x80D-5fnuA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		3 / 3 HIS A 436
ARG A 415
ILE A 461
 None
L6I  A1615 (-4.0A)
None
 0.76A 6fgdA-5fnuA:
undetectable		 6fgdA-5fnuA:
21.61