SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5foe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 4 THR A 304
PRO A 303
THR A 308
PRO A 306
 None
 1.23A 1dsdC-5foeA:
undetectable		 1dsdC-5foeA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 4 THR A 308
PRO A 306
THR A 304
PRO A 303
 None
 1.25A 1dsdC-5foeA:
undetectable		 1dsdC-5foeA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 4 THR A 304
PRO A 303
THR A 308
PRO A 306
 None
 1.23A 1dsdC-5foeA:
undetectable		 1dsdC-5foeA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 4 THR A 308
PRO A 306
THR A 304
PRO A 303
 None
 1.25A 1dsdC-5foeA:
undetectable		 1dsdC-5foeA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 GLY A 378
ASP A 329
SER A 379
ALA A 330
 None
GDP  A1428 (-3.8A)
None
None
 0.99A 1gxsA-5foeA:
undetectable
1gxsB-5foeA:
undetectable		 1gxsA-5foeA:
18.67
1gxsB-5foeA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 12 LEU A 326
ILE A 305
GLY A 307
ALA A 309
LEU A 312
 None
 1.05A 2aylB-5foeA:
undetectable		 2aylB-5foeA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 9 LEU A  71
TYR A  78
VAL A  68
VAL A 214
VAL A 131
 None
 1.35A 3cs9C-5foeA:
undetectable		 3cs9C-5foeA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 TYR A 133
TYR A 162
PHE A 174
TYR A 175
 None
 1.17A 3ku9B-5foeA:
undetectable		 3ku9B-5foeA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 12 TRP A  85
PHE A 104
ILE A 364
GLY A 360
ALA A 363
 None
None
None
EDO  A1429 ( 3.9A)
GDP  A1428 (-3.8A)
 1.26A 3n8xA-5foeA:
undetectable		 3n8xA-5foeA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 PHE A 185
ARG A 152
LEU A 200
THR A 219
 None
 1.00A 3nxuA-5foeA:
undetectable		 3nxuA-5foeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 ILE A 287
LEU A 285
THR A 308
ILE A 311
 None
 0.95A 3p50A-5foeA:
undetectable		 3p50A-5foeA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 ILE A 287
LEU A 285
THR A 308
ILE A 311
 None
 0.95A 3p50B-5foeA:
undetectable		 3p50B-5foeA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 ILE A 287
LEU A 285
THR A 308
ILE A 311
 None
 0.95A 3p50C-5foeA:
undetectable		 3p50C-5foeA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 ILE A 287
LEU A 285
THR A 308
ILE A 311
 None
 0.95A 3p50D-5foeA:
undetectable		 3p50D-5foeA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		3 / 3 PHE A 206
SER A 209
GLN A 130
 None
 0.77A 3smtA-5foeA:
undetectable		 3smtA-5foeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 11 VAL A  64
LEU A 197
THR A 196
GLU A 218
ALA A 217
 None
 1.25A 4e0fA-5foeA:
undetectable		 4e0fA-5foeA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 8 ASP A 262
ASP A 259
VAL A 244
LEU A 369
 None
 1.06A 4f8hA-5foeA:
undetectable
4f8hB-5foeA:
undetectable		 4f8hA-5foeA:
20.84
4f8hB-5foeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 8 ASP A 262
ASP A 259
VAL A 244
LEU A 369
 None
 1.10A 4f8hB-5foeA:
undetectable
4f8hC-5foeA:
undetectable		 4f8hB-5foeA:
20.84
4f8hC-5foeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 8 ASP A 262
ASP A 259
VAL A 244
LEU A 369
 None
 1.06A 4f8hC-5foeA:
undetectable
4f8hD-5foeA:
undetectable		 4f8hC-5foeA:
20.84
4f8hD-5foeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 8 ASP A 262
ASP A 259
VAL A 244
LEU A 369
 None
 1.07A 4f8hD-5foeA:
undetectable
4f8hE-5foeA:
undetectable		 4f8hD-5foeA:
20.84
4f8hE-5foeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 8 VAL A 244
LEU A 369
ASP A 262
ASP A 259
 None
 1.09A 4f8hA-5foeA:
undetectable
4f8hE-5foeA:
undetectable		 4f8hA-5foeA:
20.84
4f8hE-5foeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 12 THR A 219
LEU A 134
VAL A  64
LEU A 197
ILE A 212
 None
 1.10A 4g1bA-5foeA:
4.0		 4g1bA-5foeA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		3 / 3 ASP A 259
ASP A 248
ASN A 241
 None
 0.54A 4q5mA-5foeA:
undetectable		 4q5mA-5foeA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 TRP A 420
TRP A 231
HIS A 222
GLU A 227
 None
 1.44A 5ad9A-5foeA:
undetectable
5ad9B-5foeA:
undetectable		 5ad9A-5foeA:
20.68
5ad9B-5foeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 10 GLY A 282
SER A 257
LEU A 255
LEU A 369
TYR A 325
 None
 1.32A 5hwkA-5foeA:
undetectable		 5hwkA-5foeA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 10 GLY A 282
SER A 257
LEU A 255
LEU A 369
TYR A 325
 None
 1.32A 5hwkB-5foeA:
undetectable		 5hwkB-5foeA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 8 TRP A 141
TYR A 145
ARG A1025
GLN A1042
 None
 1.34A 5tzoC-5foeA:
undetectable		 5tzoC-5foeA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 8 ARG A 216
ARG A  57
VAL A  96
GLN A 367
 None
 1.16A 6fbvD-5foeA:
undetectable		 6fbvD-5foeA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		3 / 3 PHE A 386
ARG A 387
GLN A 389
 None
 0.94A 6g1pB-5foeA:
1.6		 6g1pB-5foeA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		3 / 3 ARG A  57
PHE A 118
PHE A  50
 None
 1.00A 6nknC-5foeA:
undetectable
6nknJ-5foeA:
undetectable		 6nknC-5foeA:
17.07
6nknJ-5foeA:
8.08