SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		4 / 7 ILE A 411
TYR A 287
PHE A 283
PHE A 309
 None
 1.07A 1e71M-5fofA:
undetectable		 1e71M-5fofA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		4 / 7 ILE A 411
TYR A 287
PHE A 283
PHE A 309
 None
 1.04A 1e72M-5fofA:
undetectable		 1e72M-5fofA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		4 / 7 MET A 535
TYR A 540
ALA A 326
THR A 320
 None
 0.92A 2wx2A-5fofA:
undetectable		 2wx2A-5fofA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		4 / 5 PRO A 435
ILE A 433
TYR A 331
TYR A 432
 None
 1.17A 3d9lA-5fofA:
undetectable
3d9lY-5fofA:
undetectable		 3d9lA-5fofA:
16.67
3d9lY-5fofA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		5 / 9 ILE A 491
GLN A 529
GLY A 501
ASN A 499
SER A 489
 None
 1.48A 4a3uA-5fofA:
undetectable		 4a3uA-5fofA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		3 / 3 PRO A 435
LEU A 434
HIS A 484
 None
 0.63A 4pevA-5fofA:
undetectable		 4pevA-5fofA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		5 / 10 ILE A 314
ILE A 377
VAL A 277
THR A 421
ILE A 433
 None
 1.28A 5lg3F-5fofA:
undetectable		 5lg3F-5fofA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		5 / 10 ILE A 314
ILE A 377
VAL A 277
THR A 421
ILE A 433
 None
 1.25A 5lg3G-5fofA:
undetectable		 5lg3G-5fofA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		5 / 10 ILE A 314
ILE A 377
VAL A 277
THR A 421
ILE A 433
 None
 1.27A 5lg3H-5fofA:
undetectable		 5lg3H-5fofA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5fof LEUCYL-TRNA
SYNTHETASE
(Plasmodium
knowlesi) 		4 / 8 PHE A 283
LEU A 419
ILE A 411
VAL A 342
 None
 0.84A 5nujA-5fofA:
undetectable		 5nujA-5fofA:
14.29