SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5foi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		5 / 10 LEU A 267
ASP A 275
ILE A 378
GLY A 380
ILE A 381
 None
 1.10A 1d4yA-5foiA:
undetectable		 1d4yA-5foiA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		4 / 6 GLU A 346
LEU A 342
LEU A 147
GLY A 148
 HEM  A 413 ( 4.5A)
HEM  A 413 ( 4.9A)
None
None
 0.91A 1n13H-5foiA:
undetectable
1n13K-5foiA:
undetectable		 1n13H-5foiA:
13.94
1n13K-5foiA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		4 / 7 LEU A 342
LEU A 147
GLY A 148
GLU A 346
 HEM  A 413 ( 4.9A)
None
None
HEM  A 413 ( 4.5A)
 0.92A 1n13G-5foiA:
undetectable
1n13J-5foiA:
undetectable		 1n13G-5foiA:
8.33
1n13J-5foiA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		5 / 12 LEU A 147
LEU A 198
ALA A 202
GLU A 205
LEU A 338
 None
None
None
None
HEM  A 413 ( 4.1A)
 1.15A 1s9pD-5foiA:
undetectable		 1s9pD-5foiA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		4 / 6 PRO A 137
MET A 138
HIS A 229
TYR A 151
 None
 1.11A 2lh8A-5foiA:
undetectable		 2lh8A-5foiA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		3 / 3 ASN A 262
LEU A 259
HIS A 321
 None
 0.86A 2q6fB-5foiA:
undetectable		 2q6fB-5foiA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		3 / 3 ALA A 227
THR A 231
CYH A 337
 HEM  A 413 ( 3.7A)
HEM  A 413 (-3.6A)
HEM  A 413 (-2.1A)
 0.42A 3e4eA-5foiA:
32.8		 3e4eA-5foiA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		3 / 3 ALA A 227
THR A 231
CYH A 337
 HEM  A 413 ( 3.7A)
HEM  A 413 (-3.6A)
HEM  A 413 (-2.1A)
 0.37A 3e4eB-5foiA:
32.7		 3e4eB-5foiA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		4 / 6 LEU A 361
VAL A 142
VAL A 236
ILE A 117
 None
 0.95A 3k5vA-5foiA:
undetectable		 3k5vA-5foiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		5 / 10 VAL A  41
ALA A 280
ARG A 279
VAL A  56
ILE A 292
 None
None
HEM  A 413 (-2.9A)
None
None
 1.30A 3retA-5foiA:
1.7
3retB-5foiA:
0.4		 3retA-5foiA:
13.11
3retB-5foiA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_B_SALB201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		5 / 9 VAL A  41
ALA A 280
ARG A 279
VAL A  56
ILE A 292
 None
None
HEM  A 413 (-2.9A)
None
None
 1.36A 3retB-5foiA:
0.5		 3retB-5foiA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		4 / 8 PRO A  15
TRP A   4
SER A 303
ARG A  22
 None
 1.06A 3sfeB-5foiA:
undetectable
3sfeC-5foiA:
2.1		 3sfeB-5foiA:
18.20
3sfeC-5foiA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		4 / 7 ALA A 233
PRO A 137
LEU A 131
THR A 132
 None
 0.78A 4du2B-5foiA:
33.4		 4du2B-5foiA:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		6 / 7 LEU A  80
THR A 231
ALA A 274
LEU A 277
ARG A 279
ILE A 378
 HEM  A 413 ( 3.7A)
HEM  A 413 (-3.6A)
HEM  A 413 (-3.6A)
HEM  A 413 ( 3.9A)
HEM  A 413 (-2.9A)
None
 0.48A 4ubsA-5foiA:
53.6		 4ubsA-5foiA:
42.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		5 / 12 LEU A 223
LEU A  80
THR A 231
ALA A 274
LEU A 302
 MY8  A 414 (-4.0A)
HEM  A 413 ( 3.7A)
HEM  A 413 (-3.6A)
HEM  A 413 (-3.6A)
None
 1.13A 5ienB-5foiA:
undetectable		 5ienB-5foiA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		5 / 7 LEU A  80
LEU A 223
ALA A 226
ALA A 227
THR A 231
 HEM  A 413 ( 3.7A)
MY8  A 414 (-4.0A)
MY8  A 414 ( 3.9A)
HEM  A 413 ( 3.7A)
HEM  A 413 (-3.6A)
 0.72A 6a7jA-5foiA:
43.7		 6a7jA-5foiA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		5 / 12 ILE A 273
HIS A 271
THR A 242
LEU A 136
ALA A 135
 None
 1.24A 6djzA-5foiA:
undetectable		 6djzA-5foiA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE
(Micromonospora
griseorubida) 		4 / 8 ASP A 195
GLY A 228
SER A 232
VAL A 142
 None
HEM  A 413 (-3.5A)
HEM  A 413 (-3.6A)
None
 0.81A 6giqL-5foiA:
undetectable
6giqP-5foiA:
undetectable
6giqT-5foiA:
undetectable		 6giqL-5foiA:
23.52
6giqP-5foiA:
19.80
6giqT-5foiA:
8.93