SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		5 / 10 VAL A 362
TYR A 354
TYR A 358
GLY A 360
TYR A 539
 None
 1.42A 1fk9A-5folA:
undetectable		 1fk9A-5folA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		5 / 10 VAL A 362
TYR A 354
TYR A 358
GLY A 360
TYR A 539
 None
 1.46A 1lw0A-5folA:
undetectable		 1lw0A-5folA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		4 / 5 PRO A 303
ILE A 392
GLY A 388
TYR A 307
 None
 1.03A 2jkjD-5folA:
undetectable		 2jkjD-5folA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		4 / 5 PRO A 303
ILE A 392
GLY A 388
TYR A 307
 None
 1.03A 2jkjF-5folA:
undetectable		 2jkjF-5folA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		4 / 6 ILE A 483
THR A 442
LYS A 443
TYR A 434
 None
 1.32A 3elzB-5folA:
undetectable		 3elzB-5folA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		5 / 9 VAL A 362
TYR A 354
TYR A 358
GLY A 360
TYR A 539
 None
 1.44A 3lp0A-5folA:
undetectable		 3lp0A-5folA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		5 / 10 VAL A 362
TYR A 354
TYR A 358
GLY A 360
TYR A 539
 None
 1.44A 3qipA-5folA:
undetectable		 3qipA-5folA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		3 / 3 TYR A 539
ARG A 351
SER A 352
 None
 1.07A 4lf7I-5folA:
undetectable
4lf7J-5folA:
undetectable		 4lf7I-5folA:
20.34
4lf7J-5folA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		3 / 3 TYR A 539
ARG A 351
SER A 352
 None
 1.07A 4lf8I-5folA:
undetectable
4lf8J-5folA:
undetectable		 4lf8I-5folA:
20.34
4lf8J-5folA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		5 / 12 SER A 529
THR A 287
THR A 259
ALA A 536
TYR A 294
 None
SO8  A1544 (-3.7A)
None
None
None
 1.41A 5dsgA-5folA:
undetectable		 5dsgA-5folA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		5 / 12 SER A 529
THR A 287
THR A 259
ALA A 536
TYR A 294
 None
SO8  A1544 (-3.7A)
None
None
None
 1.42A 5dsgB-5folA:
undetectable		 5dsgB-5folA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		3 / 3 ASN A 355
TYR A 539
CYH A 348
 None
 1.04A 5lsuB-5folA:
undetectable		 5lsuB-5folA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		5 / 12 PRO A 303
LEU A 302
ASP A 433
SER A 413
THR A 297
 None
None
SO8  A1544 (-2.7A)
None
None
 1.35A 6b50A-5folA:
undetectable		 6b50A-5folA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		5 / 10 VAL A 362
TYR A 354
TYR A 358
GLY A 360
TYR A 539
 None
 1.50A 6bsgA-5folA:
undetectable		 6bsgA-5folA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5fol LEUCYL-TRNA
SYNTHETASE
(Cryptosporidium
muris) 		4 / 8 ILE A 406
GLN A 296
PRO A 399
ILE A 408
 None
 1.04A 6cduG-5folA:
undetectable
6cduH-5folA:
undetectable		 6cduG-5folA:
21.04
6cduH-5folA:
21.04