SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5for'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.18A 1hrkA-5forA:
4.3		 1hrkA-5forA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A  24
VAL A  96
VAL A 131
TRP A  20
LEU A  67
 None
None
I3C  A1141 (-4.3A)
1PE  A1140 (-3.3A)
None
 1.43A 1jkhA-5forA:
undetectable
1jkhB-5forA:
undetectable		 1jkhA-5forA:
11.98
1jkhB-5forA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 121
LEU A  98
VAL A  65
CYH A  63
LEU A  24
 None
 1.00A 2bxfA-5forA:
undetectable		 2bxfA-5forA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.20A 2hrcA-5forA:
undetectable		 2hrcA-5forA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.16A 2po7A-5forA:
3.2		 2po7A-5forA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.20A 2po7B-5forA:
3.5		 2po7B-5forA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.13A 2qd4A-5forA:
3.2		 2qd4A-5forA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.16A 2qd4B-5forA:
3.6		 2qd4B-5forA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A  68
ALA A  70
LEU A  72
SER A  14
 None
 1.05A 3cfqA-5forA:
undetectable		 3cfqA-5forA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A  82
LEU A  85
LEU A  68
HIS A  77
LEU A  72
 MLY  A  78 ( 4.6A)
None
None
None
None
 1.38A 3q1eB-5forA:
undetectable
3q1eD-5forA:
undetectable		 3q1eB-5forA:
21.05
3q1eD-5forA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A  68
ALA A  70
LEU A  72
SER A  14
 None
 1.06A 4ikiB-5forA:
undetectable		 4ikiB-5forA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A  68
ALA A  70
LEU A  72
SER A  14
 None
 1.04A 4iklA-5forA:
undetectable
4iklB-5forA:
undetectable		 4iklA-5forA:
19.01
4iklB-5forA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		4 / 5 TYR A  13
GLU A  47
GLY A  45
SER A  14
 None
 1.34A 5jhdJ-5forA:
undetectable		 5jhdJ-5forA:
21.63