SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		3 / 3 THR A  64
THR A  66
PRO A  63
 None
 0.74A 1dscC-5fpnA:
undetectable		 1dscC-5fpnA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  19
ALA A 372
SER A  16
ALA A 131
ILE A   7
 None
 1.17A 1nt2A-5fpnA:
undetectable		 1nt2A-5fpnA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 232
GLY A 204
GLY A 205
LEU A 230
ASN A 237
 None
 0.94A 1qzzA-5fpnA:
2.0		 1qzzA-5fpnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		3 / 3 THR A  64
THR A  66
PRO A  63
 None
 0.85A 1unjW-5fpnA:
undetectable		 1unjW-5fpnA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 232
GLY A 204
GLY A 205
LEU A 230
ASN A 237
 None
 0.95A 1xdsA-5fpnA:
undetectable		 1xdsA-5fpnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 232
GLY A 204
GLY A 205
LEU A 230
ASN A 237
 None
 0.94A 1xdsB-5fpnA:
undetectable		 1xdsB-5fpnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 299
LEU A 276
ILE A 345
PRO A 346
PHE A 312
 None
None
KYD  A1386 ( 4.2A)
None
None
 1.05A 2ygqA-5fpnA:
undetectable		 2ygqA-5fpnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 340
GLY A 341
GLY A 232
ASP A 234
ARG A 274
 None
KYD  A1386 (-3.7A)
None
None
None
 0.95A 3huoB-5fpnA:
undetectable		 3huoB-5fpnA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		3 / 3 ILE A  67
SER A 120
SER A  40
 None
 0.55A 3iltH-5fpnA:
undetectable		 3iltH-5fpnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 11 ILE A 214
ALA A 178
ILE A 199
VAL A 337
VAL A 197
 None
 0.92A 3kw4A-5fpnA:
undetectable		 3kw4A-5fpnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 ILE A 214
ALA A 178
ILE A 199
VAL A 337
VAL A 197
 None
 0.82A 3me6A-5fpnA:
undetectable		 3me6A-5fpnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		4 / 8 ILE A 214
ALA A 178
VAL A 337
VAL A 197
 None
 0.71A 3me6B-5fpnA:
undetectable		 3me6B-5fpnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 12 ASP A 208
ALA A 180
VAL A 337
SER A 210
THR A 145
 None
 1.16A 4mm4B-5fpnA:
undetectable		 4mm4B-5fpnA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		7 / 10 GLY A 203
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 1.02A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 232
GLY A 340
SER A 342
ILE A 345
 None
None
None
KYD  A1386 ( 4.3A)
KYD  A1386 ( 4.2A)
 0.94A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 232
GLY A 341
SER A 342
ILE A 348
 None
None
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
None
 0.93A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 204
GLY A 232
LYS A 273
ARG A 274
SER A 277
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
None
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.2A)
 0.77A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 204
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 0.50A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 231
GLY A 232
LYS A 273
SER A 277
SER A 342
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.3A)
KYD  A1386 ( 4.2A)
 1.25A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 203
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 1.05A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 232
GLY A 341
SER A 342
ILE A 348
 None
None
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
None
 0.91A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 204
GLY A 232
LYS A 273
ARG A 274
SER A 277
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
None
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.2A)
 0.76A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 204
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 0.50A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 231
GLY A 232
LYS A 273
SER A 277
SER A 342
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.3A)
KYD  A1386 ( 4.2A)
 1.25A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 203
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 1.05A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 231
GLY A 341
SER A 342
ILE A 348
 None
None
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
None
 0.98A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 232
GLY A 341
SER A 342
ILE A 348
 None
None
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
None
 0.93A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 204
GLY A 232
LYS A 273
ARG A 274
SER A 277
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
None
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.2A)
 0.78A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 204
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 0.50A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 231
GLY A 232
LYS A 273
SER A 277
SER A 342
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.3A)
KYD  A1386 ( 4.2A)
 1.28A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		4 / 7 ASN A 237
VAL A 240
VAL A 262
ARG A 266
 None
 0.81A 5fpdA-5fpnA:
64.3		 5fpdA-5fpnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 7 VAL A 240
SER A 241
ALA A 244
GLY A 256
VAL A 262
ARG A 266
 None
 0.18A 5fpdA-5fpnA:
64.3		 5fpdA-5fpnA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 341
GLY A 340
PHE A 312
ILE A 348
PHE A 235
 KYD  A1386 (-3.7A)
None
None
None
None
 1.50A 5lbtA-5fpnA:
undetectable
5lbtB-5fpnA:
undetectable		 5lbtA-5fpnA:
16.17
5lbtB-5fpnA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B2W_A_AG2A401_1
(PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 ASP A  80
ASP A  86
THR A 228
HIS A 229
SER A  85
 None
 1.47A 6b2wA-5fpnA:
0.1		 6b2wA-5fpnA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		4 / 7 ILE A 333
GLN A 334
ALA A 180
THR A 177
 None
 0.90A 6cduC-5fpnA:
undetectable
6cduD-5fpnA:
undetectable		 6cduC-5fpnA:
18.10
6cduD-5fpnA:
18.10