SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		4 / 4 LEU A  82
ILE A 277
ARG A 270
TYR A 219
 None
 1.44A 1rk3A-5fprA:
undetectable		 1rk3A-5fprA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		5 / 12 GLN A 290
ALA A 229
PHE A 227
LEU A 239
GLN A 232
 None
 1.01A 1uduB-5fprA:
undetectable		 1uduB-5fprA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		4 / 8 SER A 233
ASP A 237
SER A 231
ASN A 285
 None
 1.10A 2cmlC-5fprA:
undetectable		 2cmlC-5fprA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		4 / 5 LEU A  82
ILE A 277
ARG A 270
TYR A 219
 None
 1.46A 2zlcA-5fprA:
undetectable		 2zlcA-5fprA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		5 / 9 ARG A 202
THR A 132
VAL A 118
ALA A 197
ALA A 198
 None
 1.25A 3ax7B-5fprA:
undetectable		 3ax7B-5fprA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		5 / 12 LYS A 112
ARG A 133
GLU A 167
VAL A 281
LYS A 283
 None
None
SO4  A1311 ( 4.8A)
None
None
 0.99A 3qwuA-5fprA:
10.3		 3qwuA-5fprA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		5 / 11 LYS A 112
ARG A 133
GLU A 167
VAL A 281
LYS A 283
 None
None
SO4  A1311 ( 4.8A)
None
None
 0.84A 3qwuB-5fprA:
10.7		 3qwuB-5fprA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		4 / 4 LEU A  82
ILE A 277
TYR A 306
TYR A 219
 None
 1.31A 3vt7A-5fprA:
1.3		 3vt7A-5fprA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		4 / 5 ILE A 102
ASN A 285
TYR A 107
ILE A  98
 None
 0.92A 4jtpA-5fprA:
undetectable		 4jtpA-5fprA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		5 / 12 LEU A 242
LEU A 239
LEU A 236
ALA A 235
GLN A 232
 None
 1.20A 4ltwA-5fprA:
undetectable		 4ltwA-5fprA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5fpr DNA LIGASE
(Staphylococcus
aureus) 		4 / 6 GLN A 129
VAL A  73
GLU A 140
ALA A 198
 None
 1.06A 6djzB-5fprA:
undetectable		 6djzB-5fprA:
21.36