SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
5 / 12 ILE A 302
VAL A 263
ALA A 101
SER A  99
GLY A 306
None
1.09A 1nbiA-5fpwA:
undetectable
1nbiA-5fpwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
5 / 12 ILE A 302
VAL A 263
ALA A 101
SER A  99
GLY A 306
None
1.10A 1nbiB-5fpwA:
undetectable
1nbiB-5fpwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
4 / 7 TYR A 248
CYH A 300
HIS A 250
TRP A  27
None
1.50A 1yvmA-5fpwA:
undetectable
1yvmA-5fpwA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
3 / 3 THR A  69
PRO A  72
TYR A 225
None
0.83A 2dxrA-5fpwA:
undetectable
2dxrA-5fpwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
5 / 12 PHE A  62
GLU A 223
ALA A 308
GLY A 228
ARG A 111
None
1.32A 3jzjA-5fpwA:
undetectable
3jzjA-5fpwA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
4 / 7 TYR A 274
GLU A  73
LEU A 269
ASN A 270
None
1.42A 3k8mA-5fpwA:
undetectable
3k8mA-5fpwA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
5 / 12 ASP A 239
THR A 259
THR A  47
ALA A  43
TYR A 248
None
1.42A 4dajB-5fpwA:
undetectable
4dajB-5fpwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
5 / 12 ASP A 239
THR A 259
THR A  47
ALA A  43
TYR A 248
None
1.49A 4u15A-5fpwA:
undetectable
4u15A-5fpwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
5 / 12 ASP A 239
THR A 259
THR A  47
ALA A  43
TYR A 248
None
1.44A 4u15B-5fpwA:
undetectable
4u15B-5fpwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
4 / 7 THR A 310
ALA A 308
LEU A 213
LEU A 214
None
0.51A 4ubsA-5fpwA:
undetectable
4ubsA-5fpwA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
5 / 12 ASP A 239
THR A 259
THR A  47
ALA A  43
TYR A 248
None
1.46A 5dsgA-5fpwA:
undetectable
5dsgA-5fpwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
4 / 6 PHE A  15
GLY A 253
THR A 238
TYR A 248
None
1.26A 6ag0C-5fpwA:
undetectable
6ag0C-5fpwA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
5fpw PRO CATHEPSIN B S9
(Trypanosoma
congolense)
4 / 6 TRP A  27
LEU A 256
ASP A 252
GLN A  21
None
1.48A 6djzC-5fpwA:
undetectable
6djzC-5fpwA:
18.98