SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 LEU B 109
ILE B 143
TYR B 153
VAL B  60
None
1.13A 1db1A-5fq6B:
undetectable
1db1A-5fq6B:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 5 PHE A 327
TYR A 347
LEU A 368
VAL A 393
None
1.38A 1dz6A-5fq6A:
undetectable
1dz6A-5fq6A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 4 THR A 209
LEU A 210
LEU A 325
GLN A 322
None
1.06A 1fbmA-5fq6A:
undetectable
1fbmA-5fq6A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 7 TRP A 392
THR A 261
GLY A 433
LEU A 254
None
1.04A 1gtiE-5fq6A:
1.2
1gtiE-5fq6A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 SER B 590
THR B 565
GLU B 649
GLY B 651
None
0.98A 1icrA-5fq6B:
undetectable
1icrB-5fq6B:
undetectable
1icrA-5fq6B:
11.71
1icrB-5fq6B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 GLU B 649
GLY B 651
SER B 590
THR B 565
None
0.96A 1icrA-5fq6B:
undetectable
1icrB-5fq6B:
undetectable
1icrA-5fq6B:
11.71
1icrB-5fq6B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 SER B 590
THR B 565
GLU B 649
GLY B 651
None
0.96A 1icuA-5fq6B:
undetectable
1icuB-5fq6B:
undetectable
1icuA-5fq6B:
11.71
1icuB-5fq6B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 GLU B 649
GLY B 651
SER B 590
THR B 565
None
0.96A 1icuA-5fq6B:
undetectable
1icuB-5fq6B:
undetectable
1icuA-5fq6B:
11.71
1icuB-5fq6B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 SER B 590
THR B 565
GLU B 649
GLY B 651
None
0.97A 1icuC-5fq6B:
undetectable
1icuD-5fq6B:
undetectable
1icuC-5fq6B:
11.71
1icuD-5fq6B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 SER B 590
THR B 565
GLU B 649
GLY B 651
None
0.97A 1icvC-5fq6B:
undetectable
1icvD-5fq6B:
undetectable
1icvC-5fq6B:
11.71
1icvD-5fq6B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 GLU B 649
GLY B 651
SER B 590
THR B 565
None
0.94A 1icvC-5fq6B:
undetectable
1icvD-5fq6B:
undetectable
1icvC-5fq6B:
11.71
1icvD-5fq6B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 GLN B 459
ASP B 460
LEU B 101
ASN B 483
KR0  B1985 (-3.6A)
None
None
None
1.26A 1ig3A-5fq6B:
undetectable
1ig3B-5fq6B:
undetectable
1ig3A-5fq6B:
14.81
1ig3B-5fq6B:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 GLY B 890
ASP B 893
TYR B 886
TRP B 887
None
1.50A 1kf6M-5fq6B:
undetectable
1kf6N-5fq6B:
undetectable
1kf6M-5fq6B:
21.50
1kf6N-5fq6B:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 SER B 590
THR B 565
GLU B 649
GLY B 651
None
0.98A 1kqbA-5fq6B:
undetectable
1kqbB-5fq6B:
undetectable
1kqbA-5fq6B:
12.70
1kqbB-5fq6B:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 GLU B 649
GLY B 651
SER B 590
THR B 565
None
0.96A 1kqbA-5fq6B:
undetectable
1kqbB-5fq6B:
undetectable
1kqbA-5fq6B:
12.70
1kqbB-5fq6B:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 SER B 590
THR B 565
GLU B 649
GLY B 651
None
0.98A 1kqbC-5fq6B:
undetectable
1kqbD-5fq6B:
undetectable
1kqbC-5fq6B:
12.70
1kqbD-5fq6B:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 GLU B 649
GLY B 651
SER B 590
THR B 565
None
0.96A 1kqbC-5fq6B:
undetectable
1kqbD-5fq6B:
undetectable
1kqbC-5fq6B:
12.70
1kqbD-5fq6B:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 ASP B 340
MET B 200
ASN B 196
TYR B 359
None
1.45A 1nbiA-5fq6B:
0.3
1nbiA-5fq6B:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 ASP B 340
MET B 200
ASN B 196
TYR B 359
None
1.43A 1nbiB-5fq6B:
0.3
1nbiB-5fq6B:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
5 / 9 LEU A 128
ALA A  88
GLY A  83
ALA A  84
PHE A 112
None
None
NA  B1986 ( 3.9A)
None
None
1.15A 1nr6A-5fq6A:
undetectable
1nr6A-5fq6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron
;
Bacteroides
thetaiotaomicron)
4 / 7 PHE A 226
ALA A  31
ILE B 614
PRO A 235
None
0.91A 1oniA-5fq6A:
undetectable
1oniB-5fq6A:
undetectable
1oniA-5fq6A:
14.59
1oniB-5fq6A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron
;
Bacteroides
thetaiotaomicron)
4 / 6 TYR A  58
PRO B 615
GLU A  37
PHE B 616
None
1.24A 1oniA-5fq6A:
undetectable
1oniC-5fq6A:
undetectable
1oniA-5fq6A:
14.59
1oniC-5fq6A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron
;
Bacteroides
thetaiotaomicron)
4 / 6 PHE A 226
ALA A  31
ILE B 614
PRO A 235
None
1.09A 1oniH-5fq6A:
undetectable
1oniI-5fq6A:
undetectable
1oniH-5fq6A:
14.59
1oniI-5fq6A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron
;
Bacteroides
thetaiotaomicron)
4 / 7 ILE B 614
PRO A 235
PHE A 226
ALA A  31
None
0.75A 1oniG-5fq6B:
undetectable
1oniI-5fq6B:
undetectable
1oniG-5fq6B:
10.58
1oniI-5fq6B:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 9 ARG B  89
GLY B 651
VAL B 650
GLU B 647
ILE B 587
None
1.29A 1pw7B-5fq6B:
undetectable
1pw7B-5fq6B:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 ASP B 599
ASP B 597
ASN B 596
GLU B 961
None
1.27A 1rjdA-5fq6B:
undetectable
1rjdA-5fq6B:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 ASP B 599
ASP B 597
ASN B 596
GLU B 961
None
1.28A 1rjdB-5fq6B:
undetectable
1rjdB-5fq6B:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 6 LEU A 254
VAL A 255
ILE A 266
TYR A  39
None
0.98A 1s9qA-5fq6A:
undetectable
1s9qA-5fq6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 LEU B 704
PHE B 724
ARG B 700
None
0.85A 1xdkF-5fq6B:
undetectable
1xdkF-5fq6B:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 MET B 753
ASN B  98
GLN B  72
None
0.88A 1xoqB-5fq6B:
undetectable
1xoqB-5fq6B:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
5 / 12 VAL A 357
ASP A 354
GLY A  35
ILE A 114
TYR A 110
None
1.31A 1xvaA-5fq6A:
undetectable
1xvaA-5fq6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
5 / 12 TYR A  39
ALA A 323
ASP A 220
SER A 394
ILE A 307
None
1.29A 1xvaB-5fq6A:
undetectable
1xvaB-5fq6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
5 / 12 TYR A  39
ALA A 323
ASP A 220
SER A 394
TYR A 268
None
1.29A 1xvaB-5fq6A:
undetectable
1xvaB-5fq6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 LEU B 191
LEU B 189
MET B 282
None
0.81A 1ya3B-5fq6B:
undetectable
1ya3B-5fq6B:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 7 SER A 310
ILE A 311
ILE A 307
ASP A 308
None
1.01A 1yc5A-5fq6A:
undetectable
1yc5A-5fq6A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 5 TYR B 369
PRO B 356
THR B 337
SER B 333
None
1.27A 1ymxA-5fq6B:
undetectable
1ymxA-5fq6B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 GLY B 345
ILE B 344
ASN B 244
SER B 342
None
0.80A 2a8tB-5fq6B:
undetectable
2a8tB-5fq6B:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 10 ILE B 777
ALA B 769
GLN B 767
ASN B 780
ILE B 855
None
1.13A 2aclC-5fq6B:
undetectable
2aclC-5fq6B:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 11 ILE B 777
ALA B 769
GLN B 767
ASN B 780
ILE B 855
None
1.12A 2aclE-5fq6B:
undetectable
2aclE-5fq6B:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 TRP B 914
ALA B 933
VAL B 931
None
0.81A 2izqA-5fq6B:
undetectable
2izqB-5fq6B:
undetectable
2izqA-5fq6B:
1.67
2izqB-5fq6B:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
3 / 3 LYS A 315
TYR A 318
PRO A 316
None
1.35A 2j9cC-5fq6A:
undetectable
2j9cC-5fq6A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 ASP B 460
THR B 401
ASN B 475
GLN B 529
None
0.98A 2jc9A-5fq6B:
undetectable
2jc9A-5fq6B:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
5 / 12 ILE A 194
GLU A 331
LEU A 187
ARG A 335
PHE A 336
None
1.15A 2jj8C-5fq6A:
undetectable
2jj8C-5fq6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 11 ALA B 769
VAL B 779
GLY B 891
PRO B 857
ILE B 777
None
0.99A 2qhcA-5fq6B:
undetectable
2qhcA-5fq6B:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
6 / 12 GLY B 762
GLY B 965
GLY B 962
THR B 954
GLU B 961
THR B 833
None
1.47A 2wa2B-5fq6B:
undetectable
2wa2B-5fq6B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 LEU B  40
ALA B 148
GLY B 146
ARG B  89
None
0.97A 2wq5A-5fq6B:
undetectable
2wq5A-5fq6B:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 9 ALA B 769
VAL B 779
GLY B 891
PRO B 857
ILE B 777
None
1.06A 3ektB-5fq6B:
undetectable
3ektB-5fq6B:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 11 ALA B 769
VAL B 779
GLY B 891
PRO B 857
ILE B 777
None
0.96A 3ekxB-5fq6B:
undetectable
3ekxB-5fq6B:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)
5fq6 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 VAL E 102
VAL E  21
THR E  45
TYR E 120
None
0.98A 3fhxB-5fq6E:
undetectable
3fhxB-5fq6E:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
3 / 3 MET A 290
CYH A 249
PRO A 284
None
1.26A 3h52C-5fq6A:
undetectable
3h52C-5fq6A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 ALA B 933
VAL B 931
TRP B 914
None
0.83A 3l8lA-5fq6B:
undetectable
3l8lB-5fq6B:
undetectable
3l8lA-5fq6B:
1.67
3l8lB-5fq6B:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron
;
Bacteroides
thetaiotaomicron)
3 / 3 PRO B 615
SER A  76
ASN B 748
None
0.85A 3lslG-5fq6B:
undetectable
3lslG-5fq6B:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ARG B 339
GLY B 212
ASN B 211
ASN B 842
TYR B 838
None
1.50A 3mekA-5fq6B:
undetectable
3mekA-5fq6B:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0Q_A_ADNA1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 9 ASN B 963
GLY B 965
SER B  74
THR B  76
THR B 954
None
1.35A 3o0qA-5fq6B:
0.0
3o0qA-5fq6B:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
5 / 10 LEU A  80
PHE A 319
ALA A  31
GLY A  35
ILE A  38
None
1.35A 3qpsA-5fq6A:
undetectable
3qpsA-5fq6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ARG B 339
GLY B 212
ASN B 211
ASN B 842
TYR B 838
None
1.45A 3qwpA-5fq6B:
undetectable
3qwpA-5fq6B:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 7 ILE A 270
VAL A 255
LEU A 258
SER A 259
None
0.60A 3r9vA-5fq6A:
undetectable
3r9vB-5fq6A:
undetectable
3r9vA-5fq6A:
20.75
3r9vB-5fq6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 GLY B 160
ALA B 157
ALA B 149
ALA B 148
SER B 590
None
1.08A 3sudA-5fq6B:
undetectable
3sudA-5fq6B:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
5 / 10 ILE A 114
TYR A  41
ILE A  38
ALA A  33
GLU A  37
None
1.37A 3u6tA-5fq6A:
undetectable
3u6tA-5fq6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 5 TYR A 388
ASP A 195
ASP A 478
ILE A 479
None
1.36A 3uj7B-5fq6A:
undetectable
3uj7B-5fq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 GLN B 446
THR B 444
ASN B 495
None
0.80A 3v4tE-5fq6B:
undetectable
3v4tE-5fq6B:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
3 / 3 TYR A 388
ASP A 195
ASP A 478
None
0.82A 4a6eA-5fq6A:
undetectable
4a6eA-5fq6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 ASN B  84
ASP B  59
ASN B 131
None
0.78A 4agaA-5fq6B:
undetectable
4agaA-5fq6B:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 ASN B 458
ASP B 460
ASN B 481
None
0.67A 4agaA-5fq6B:
undetectable
4agaA-5fq6B:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 7 THR A 239
HIS A 248
ASN A 247
TYR A  58
None
1.22A 4awuA-5fq6A:
undetectable
4awuA-5fq6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 ARG B 254
ARG B 975
ILE B 277
None
0.90A 4b7qC-5fq6B:
undetectable
4b7qC-5fq6B:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 8 HIS A 400
GLU A 402
ILE A 407
TRP A 404
None
1.01A 4cx7A-5fq6A:
undetectable
4cx7B-5fq6A:
undetectable
4cx7A-5fq6A:
21.79
4cx7B-5fq6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ASN B 313
PHE B 384
ASP B 269
GLY B 299
SER B 310
None
1.43A 4djeA-5fq6B:
undetectable
4djeA-5fq6B:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 ARG B 521
LEU B 101
ASN B 596
TYR B 561
None
1.24A 4f8yC-5fq6B:
undetectable
4f8yD-5fq6B:
undetectable
4f8yC-5fq6B:
10.24
4f8yD-5fq6B:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 GLY B 129
ASN B 111
ARG B 156
MET B  61
None
0.92A 4j4vC-5fq6B:
undetectable
4j4vC-5fq6B:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 VAL B 228
GLY B 226
LYS B 234
None
0.76A 4k50I-5fq6B:
undetectable
4k50I-5fq6B:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 9 THR B 846
GLY B 215
PHE B 198
ARG B 339
GLY B 212
None
1.20A 4kqiA-5fq6B:
undetectable
4kqiA-5fq6B:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 VAL B 731
PHE B 677
SER B  93
LEU B 960
VAL B 761
None
1.38A 4kyaB-5fq6B:
undetectable
4kyaB-5fq6B:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 VAL B 731
PHE B 677
SER B  93
LEU B 960
VAL B 761
None
1.39A 4kyaD-5fq6B:
undetectable
4kyaD-5fq6B:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 VAL B 731
PHE B 677
SER B  93
LEU B 960
VAL B 761
None
1.39A 4kyaF-5fq6B:
undetectable
4kyaF-5fq6B:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 VAL B 731
PHE B 677
SER B  93
LEU B 960
VAL B 761
None
1.38A 4kyaH-5fq6B:
undetectable
4kyaH-5fq6B:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 9 SER B 116
GLY B 123
SER B 122
TYR B 745
GLY B 119
None
1.43A 4lb0A-5fq6B:
undetectable
4lb0A-5fq6B:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 LEU B 328
VAL B 365
GLU B 443
TYR B 424
None
1.02A 4lb2A-5fq6B:
undetectable
4lb2A-5fq6B:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 9 ALA B 769
VAL B 779
GLY B 891
PRO B 857
ILE B 777
None
1.02A 4ll3B-5fq6B:
undetectable
4ll3B-5fq6B:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 TYR B  42
GLN B  99
THR B  97
THR B 646
None
1.10A 4mbsA-5fq6B:
undetectable
4mbsA-5fq6B:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 ASP B 340
TYR B 238
TRP B 225
None
1.34A 4p7nA-5fq6B:
undetectable
4p7nA-5fq6B:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 GLY B 563
GLU B  37
ALA B  39
GLY B  41
TYR B  42
None
1.21A 4r29B-5fq6B:
undetectable
4r29B-5fq6B:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
5 / 12 TRP A 392
TYR A 252
VAL A 255
ASP A 263
THR A 261
None
1.50A 4xe0A-5fq6A:
undetectable
4xe0A-5fq6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ASN B 699
GLU B 703
GLY B  70
ILE B  68
ILE B  73
None
1.13A 4xucA-5fq6B:
undetectable
4xucA-5fq6B:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 SER B  62
GLU B  54
GLU B 178
None
0.74A 4ymgB-5fq6B:
undetectable
4ymgB-5fq6B:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 SER B 438
GLY B 431
TYR B 360
GLY B 357
None
0.87A 5albL-5fq6B:
undetectable
5albL-5fq6B:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 ALA B 847
ASP B 340
GLY B 201
THR B 361
None
0.91A 5bs8A-5fq6B:
undetectable
5bs8B-5fq6B:
undetectable
5bs8C-5fq6B:
undetectable
5bs8A-5fq6B:
18.52
5bs8B-5fq6B:
12.53
5bs8C-5fq6B:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 ALA B 847
ASP B 340
GLY B 201
THR B 361
None
0.92A 5btdA-5fq6B:
undetectable
5btdC-5fq6B:
undetectable
5btdD-5fq6B:
undetectable
5btdA-5fq6B:
18.52
5btdC-5fq6B:
18.52
5btdD-5fq6B:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 ARG B 975
ASP B  59
GLY B  81
THR B 113
None
1.07A 5btfA-5fq6B:
undetectable
5btfC-5fq6B:
undetectable
5btfD-5fq6B:
undetectable
5btfA-5fq6B:
18.52
5btfC-5fq6B:
18.52
5btfD-5fq6B:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 SER B 831
GLU B 966
GLY B 891
GLY B 888
None
0.94A 5cdpA-5fq6B:
undetectable
5cdpB-5fq6B:
undetectable
5cdpA-5fq6B:
20.17
5cdpB-5fq6B:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
5 / 11 VAL A 207
VAL A 211
ILE A 387
TYR A 388
LEU A 191
None
1.05A 5e4dB-5fq6A:
undetectable
5e4dB-5fq6A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 GLY B 762
GLY B 965
GLY B 962
THR B 954
GLU B 961
None
1.05A 5ehiA-5fq6B:
undetectable
5ehiA-5fq6B:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 GLY B 762
GLY B 965
GLY B 962
THR B 954
GLU B 961
None
1.01A 5ehiC-5fq6B:
undetectable
5ehiC-5fq6B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 PRO B 135
LEU B  64
SER B  58
None
0.84A 5fsaB-5fq6B:
undetectable
5fsaB-5fq6B:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 ILE B  52
ILE B  73
THR B  45
ILE B 143
None
0.74A 5fukA-5fq6B:
undetectable
5fukB-5fq6B:
undetectable
5fukA-5fq6B:
12.94
5fukB-5fq6B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 ASN A 301
SER B 437
SER B 436
None
0.77A 5gsnA-5fq6A:
undetectable
5gsnA-5fq6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 9 ARG B  89
GLY B 651
VAL B 650
GLU B 647
ILE B 587
None
1.27A 5i3cA-5fq6B:
undetectable
5i3cA-5fq6B:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)
5fq6 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 PHE E  26
THR E 132
TYR E 133
TYR E  67
None
1.44A 5lrbA-5fq6E:
undetectable
5lrbA-5fq6E:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 GLY B 762
GLY B 965
GLY B 962
THR B 954
GLU B 961
None
1.04A 5njvD-5fq6B:
undetectable
5njvD-5fq6B:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron
;
Bacteroides
thetaiotaomicron)
5 / 12 LEU B 619
ASP A 231
ILE B 614
GLY B 617
SER B 610
None
1.16A 5twjC-5fq6B:
undetectable
5twjC-5fq6B:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 7 GLY B 796
GLN B 825
TYR B 802
ASP B 901
None
1.20A 5vlmG-5fq6B:
undetectable
5vlmG-5fq6B:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ARG B 339
GLY B 212
ASN B 211
ASN B 842
TYR B 838
None
1.39A 5xxgA-5fq6B:
undetectable
5xxgA-5fq6B:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ARG B 339
GLY B 212
ASN B 211
ASN B 842
TYR B 838
None
1.43A 5xxjA-5fq6B:
undetectable
5xxjA-5fq6B:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 ARG B 339
GLY B 212
ASN B 211
ASN B 842
TYR B 838
None
1.42A 5yjoA-5fq6B:
undetectable
5yjoA-5fq6B:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 ASN B  98
LEU B 960
ASN B 699
ILE B 697
None
0.81A 6cb4A-5fq6B:
undetectable
6cb4A-5fq6B:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
4 / 4 VAL A 116
GLY A 141
ASP A 121
ASP A 139
None
1.32A 6cjkC-5fq6A:
undetectable
6cjkC-5fq6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
3 / 3 GLN B 276
TYR B 255
ASN B 257
None
0.96A 6dwdC-5fq6B:
undetectable
6dwdC-5fq6B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 GLY B 563
THR B 543
TRP B 591
TYR B  42
None
1.07A 6eqpA-5fq6B:
undetectable
6eqpA-5fq6B:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 8 ILE B 457
VAL B 487
ARG B 485
ASP B 597
KR0  B1985 (-4.0A)
None
None
None
1.00A 6hu9a-5fq6B:
undetectable
6hu9e-5fq6B:
undetectable
6hu9a-5fq6B:
21.61
6hu9e-5fq6B:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
3 / 3 TRP A 477
ILE A 479
ASP A 478
None
0.90A 6i0y7-5fq6A:
undetectable
6i0y7-5fq6A:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
3 / 3 ASN A 301
PRO A  53
GLN A  51
None
0.84A 6jnhA-5fq6A:
undetectable
6jnhA-5fq6A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
5fq6 PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron)
3 / 3 ASN A 301
PRO A  53
GLN A  51
None
0.82A 6jogA-5fq6A:
undetectable
6jogA-5fq6A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
5 / 12 LEU B 191
PHE B 248
VAL B 188
PRO B 971
GLY B 325
None
1.09A 6mn8A-5fq6B:
undetectable
6mn8A-5fq6B:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron
;
Bacteroides
thetaiotaomicron)
5 / 12 GLY B 427
GLY B 435
GLY B 433
ASP A 308
PHE B 440
None
1.06A 6nj9K-5fq6B:
undetectable
6nj9K-5fq6B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron)
4 / 6 GLN B 389
PHE B 388
LEU B 312
PHE B 384
None
1.26A 6nmpC-5fq6B:
undetectable
6nmpJ-5fq6B:
undetectable
6nmpC-5fq6B:
15.57
6nmpJ-5fq6B:
4.57