SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A1032
ASP A1092
LEU A 974
LEU A1000
GLY A1001
 None
 1.35A 1d4fD-5fqdA:
undetectable		 1d4fD-5fqdA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		4 / 8 LEU C  19
ALA C  34
VAL C  43
VAL C  89
 None
 0.84A 1epbB-5fqdC:
undetectable		 1epbB-5fqdC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A1029
VAL A1028
SER A1027
VAL A1004
LEU A1000
 None
 1.19A 1ie9A-5fqdA:
undetectable		 1ie9A-5fqdA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A  31
VAL A  15
GLY A  17
TYR A  42
 None
 0.97A 1lweA-5fqdA:
undetectable		 1lweA-5fqdA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A  22
PHE A  23
ARG A 103
LEU A  76
GLU A  72
 None
 1.34A 1mjlA-5fqdA:
undetectable
1mjlB-5fqdA:
undetectable		 1mjlA-5fqdA:
8.62
1mjlB-5fqdA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ARG A 103
LEU A  76
GLU A  72
HIS A  22
PHE A  23
 None
 1.33A 1mjlA-5fqdA:
undetectable
1mjlB-5fqdA:
undetectable		 1mjlA-5fqdA:
8.62
1mjlB-5fqdA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ARG A 103
LEU A  76
GLU A  72
HIS A  22
PHE A  23
 None
 1.20A 1mjqA-5fqdA:
undetectable
1mjqB-5fqdA:
undetectable		 1mjqA-5fqdA:
8.62
1mjqB-5fqdA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A  22
PHE A  23
ARG A 103
LEU A  76
GLU A  72
 None
 1.23A 1mjqA-5fqdA:
undetectable
1mjqB-5fqdA:
undetectable		 1mjqA-5fqdA:
8.62
1mjqB-5fqdA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 HIS A  22
PHE A  23
ARG A 103
LEU A  76
GLU A  72
 None
 1.22A 1mjqG-5fqdA:
undetectable
1mjqH-5fqdA:
undetectable		 1mjqG-5fqdA:
8.62
1mjqH-5fqdA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 THR A1125
LEU A1129
VAL A1132
LEU A1136
 None
 0.94A 1mz9D-5fqdA:
undetectable		 1mz9D-5fqdA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A1031
GLY A1038
VAL A 360
ASP A 361
VAL A1006
 None
 1.12A 1n2xA-5fqdA:
undetectable		 1n2xA-5fqdA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A  61
ALA A  34
GLY A  17
GLU A 312
ASN A 355
 None
 1.16A 1n6cA-5fqdA:
undetectable		 1n6cA-5fqdA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 SER A 326
SER A 331
LEU A 314
PHE A 323
 None
 1.46A 1r5lA-5fqdA:
undetectable		 1r5lA-5fqdA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A  88
ARG A 103
LEU A 145
PRO A  69
 None
 1.43A 1s8fA-5fqdA:
undetectable
1s8fB-5fqdA:
undetectable		 1s8fA-5fqdA:
12.05
1s8fB-5fqdA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		4 / 5 LYS C 130
PHE C 142
LEU C  67
LEU C 277
 None
 1.48A 1skxA-5fqdC:
undetectable		 1skxA-5fqdC:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ILE A  88
ASP A  75
PHE A  23
 None
 0.30A 1uwjB-5fqdA:
undetectable		 1uwjB-5fqdA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PRO A 206
GLY A 242
ASN A 241
GLY A 228
 None
 1.07A 1zlqA-5fqdA:
undetectable		 1zlqA-5fqdA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLU A1095
ASP A1090
PHE A 998
ARG A1074
 None
 1.23A 2a3bB-5fqdA:
undetectable		 2a3bB-5fqdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		4 / 7 ARG C 123
GLY C  72
SER C 122
GLU C 125
 None
 0.95A 2c8aB-5fqdC:
undetectable		 2c8aB-5fqdC:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 975
GLY A 996
ALA A1085
PHE A 965
ASN A 964
 None
 1.14A 2dpmA-5fqdA:
undetectable		 2dpmA-5fqdA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 975
GLY A1087
ALA A1085
PHE A 965
ASN A 964
 None
 1.09A 2dpmA-5fqdA:
undetectable		 2dpmA-5fqdA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A1068
VAL A 108
LEU A  80
PHE A  78
ALA A 104
 None
 1.26A 2jj8C-5fqdA:
undetectable		 2jj8C-5fqdA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A1051
MET A1054
LEU A1058
GLU A1095
 None
 1.19A 2kuhA-5fqdA:
undetectable		 2kuhA-5fqdA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A1096
ILE A1094
ASP A1090
ARG A1074
 None
 1.05A 2v57A-5fqdA:
undetectable		 2v57A-5fqdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A1096
ILE A1094
ASP A1090
ARG A1074
 None
 1.05A 2v57C-5fqdA:
undetectable		 2v57C-5fqdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A1032
ASP A1092
LEU A 974
LEU A1000
GLY A1001
 None
 1.37A 2zj0C-5fqdA:
undetectable		 2zj0C-5fqdA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PRO A  12
THR A  13
ILE A 359
ILE A 390
LEU A1029
 None
 1.27A 3a50E-5fqdA:
undetectable		 3a50E-5fqdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLU A 161
ILE A 178
LEU A 197
ILE A 157
MET A 130
 None
 1.41A 3adsA-5fqdA:
undetectable		 3adsA-5fqdA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A1037
GLN A  10
GLY A1038
LEU A1000
 None
 0.61A 3bjwB-5fqdA:
undetectable		 3bjwB-5fqdA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A1037
GLN A  10
GLY A1038
LEU A1000
 None
 0.64A 3bjwF-5fqdA:
undetectable		 3bjwF-5fqdA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A1037
GLN A  10
GLY A1038
LEU A1000
 None
 0.59A 3bjwH-5fqdA:
undetectable		 3bjwH-5fqdA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 8 LEU A1000
ASN A1005
THR A 377
VAL A1004
GLY A1038
 None
 1.38A 3dcjB-5fqdA:
undetectable		 3dcjB-5fqdA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A 171
TYR A 271
ILE A 220
 None
 0.78A 3eteA-5fqdA:
undetectable
3eteB-5fqdA:
undetectable		 3eteA-5fqdA:
21.26
3eteB-5fqdA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A1032
ASP A1092
LEU A 974
LEU A1000
GLY A1001
 None
 1.32A 3glqA-5fqdA:
undetectable		 3glqA-5fqdA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A1032
ASP A1092
LEU A 974
LEU A1000
GLY A1001
 None
 1.29A 3glqB-5fqdA:
undetectable		 3glqB-5fqdA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		5 / 12 ALA C  44
LYS C  46
GLU C  60
LEU C  63
LEU C  92
 None
 0.74A 3hecA-5fqdC:
15.1		 3hecA-5fqdC:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		5 / 8 ALA C  44
LYS C  46
GLU C  60
LEU C  88
LEU C  92
 None
 0.87A 3lfaA-5fqdC:
17.7		 3lfaA-5fqdC:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 VAL A1006
VAL A1004
LEU A1000
VAL A1028
GLY A1038
 None
 1.16A 3ls4H-5fqdA:
undetectable		 3ls4H-5fqdA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A1032
ASP A1092
LEU A 974
LEU A1000
GLY A1001
 None
 1.30A 3n58A-5fqdA:
undetectable		 3n58A-5fqdA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		5 / 12 ILE C  76
TYR C  64
ALA C  44
LEU C  57
GLY C  94
 None
 1.13A 3ozwB-5fqdC:
undetectable		 3ozwB-5fqdC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 154
TYR A  84
LEU A 135
ILE A  79
ILE A1068
 None
 1.15A 3prsA-5fqdA:
undetectable		 3prsA-5fqdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A 304
GLY A 306
LEU A 280
GLU A 307
 None
 1.10A 3tgvB-5fqdA:
undetectable		 3tgvB-5fqdA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A  61
ALA A  34
GLY A  17
GLU A 312
ASN A 355
 None
 1.20A 4e47A-5fqdA:
undetectable		 4e47A-5fqdA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A  61
ALA A  34
GLY A  17
GLU A 312
ASN A 355
 None
 1.23A 4e47B-5fqdA:
undetectable		 4e47B-5fqdA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A  61
ALA A  34
GLY A  17
GLU A 312
ASN A 355
 None
 1.16A 4e47C-5fqdA:
undetectable		 4e47C-5fqdA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 227
GLY A 228
TYR A 239
GLU A 224
 None
 1.05A 4fgkB-5fqdA:
undetectable		 4fgkB-5fqdA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		4 / 7 ILE C 121
TYR C 274
PRO C 272
HIS C 128
 None
 1.15A 4g5jA-5fqdC:
21.0		 4g5jA-5fqdC:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A  61
ALA A  34
GLY A  17
GLU A 312
ASN A 355
 None
 1.24A 4jdsA-5fqdA:
undetectable		 4jdsA-5fqdA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A  61
ALA A  34
GLY A  17
GLU A 312
ASN A 355
 None
 1.22A 4jdsB-5fqdA:
undetectable		 4jdsB-5fqdA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A  61
ALA A  34
GLY A  17
GLU A 312
ASN A 355
 None
 1.16A 4jdsC-5fqdA:
undetectable		 4jdsC-5fqdA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  61
ALA A  34
GLY A  17
GLU A 312
ASN A 355
 None
 1.14A 4jlgA-5fqdA:
undetectable		 4jlgA-5fqdA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A1074
PHE A 998
GLY A1038
THR A   8
 None
 1.01A 4k87A-5fqdA:
undetectable		 4k87A-5fqdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		6 / 10 ILE C  23
ALA C  44
MET C  90
LEU C  93
GLY C  94
LEU C 143
 None
 1.27A 4ks8A-5fqdC:
24.5		 4ks8A-5fqdC:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		4 / 6 ARG C 201
GLY C 265
PRO C 272
HIS C 128
 None
 1.05A 4lajA-5fqdC:
undetectable
4lajB-5fqdC:
undetectable		 4lajA-5fqdC:
19.90
4lajB-5fqdC:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 866
ILE A 830
TYR A 891
LEU A 736
ALA A 882
 None
 1.30A 4m83A-5fqdA:
undetectable		 4m83A-5fqdA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 CYH A  87
GLY A 106
ASN A 107
ILE A  79
GLY A1066
 None
 1.25A 4n48A-5fqdA:
undetectable		 4n48A-5fqdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O79_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LYS A 915
TYR A 913
ALA A 968
MET A 954
 None
 1.41A 4o79B-5fqdA:
0.0		 4o79B-5fqdA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LYS A 915
TYR A 913
ALA A 968
MET A 954
 None
 1.42A 4o7gB-5fqdA:
undetectable		 4o7gB-5fqdA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A 811
THR A 860
HIS A 805
 None
 0.86A 4q15B-5fqdA:
undetectable		 4q15B-5fqdA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 11 GLY A 132
MET A 130
ILE A 178
GLY A 138
ILE A 157
PHE A 155
 None
 1.08A 4qoiA-5fqdA:
undetectable
4qoiB-5fqdA:
undetectable		 4qoiA-5fqdA:
13.87
4qoiB-5fqdA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		5 / 10 ILE C  23
ALA C  44
LYS C  46
LEU C  92
LEU C 143
 None
 0.60A 4rz7A-5fqdC:
23.4		 4rz7A-5fqdC:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		7 / 12 ALA C  44
LYS C  46
GLU C  60
LEU C  88
LEU C  92
GLY C  94
LEU C 143
 None
 1.36A 4wkqA-5fqdC:
21.8		 4wkqA-5fqdC:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 317
ASP A 330
ALA A 349
PHE A 353
THR A 354
 None
 1.36A 4z7fA-5fqdA:
undetectable		 4z7fA-5fqdA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 808
ALA A 804
PHE A 851
ARG A 847
LYS A 769
 None
 1.27A 4z7fA-5fqdA:
undetectable		 4z7fA-5fqdA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A1091
LEU A 710
ILE A 389
GLY A 373
LEU A1029
 None
 1.03A 4ze2A-5fqdA:
undetectable		 4ze2A-5fqdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A1011
GLU A1002
LEU A 974
THR A1032
GLY A1031
 None
 1.40A 4zjlA-5fqdA:
undetectable		 4zjlA-5fqdA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A  61
ALA A  34
GLY A  17
GLU A 312
ASN A 355
 None
 1.17A 5ayfA-5fqdA:
undetectable		 5ayfA-5fqdA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASN A 203
SER A 196
ARG A 198
 None
 0.93A 5b2qA-5fqdA:
undetectable		 5b2qA-5fqdA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  32
ILE A 131
GLY A 122
ILE A 123
GLY A  17
 None
 1.01A 5d4uC-5fqdA:
undetectable		 5d4uC-5fqdA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 943
ALA A 934
ASN A 941
GLU A 939
 None
 1.33A 5dwkC-5fqdA:
undetectable		 5dwkC-5fqdA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PHE A1097
ILE A1130
MET A1105
GLN A1106
 None
 1.32A 5jm4A-5fqdA:
undetectable		 5jm4A-5fqdA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 712
ILE A 390
THR A  13
ASN A1034
ALA A   9
 None
 1.08A 5lg3E-5fqdA:
undetectable		 5lg3E-5fqdA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		4 / 7 GLY C 145
ASP C  91
PHE C 154
ASN C 151
 None
 0.99A 5mvsA-5fqdC:
undetectable		 5mvsA-5fqdC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		4 / 5 PHE C 154
PHE C 142
LEU C 153
LEU C  67
 None
 1.26A 5veuH-5fqdC:
undetectable		 5veuH-5fqdC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_1
(-)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A1032
ASP A1092
LEU A 974
LEU A1000
GLY A1001
 None
 1.32A 6f3nA-5fqdA:
undetectable		 6f3nA-5fqdA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A1032
ASP A1092
LEU A 974
LEU A1000
GLY A1001
 None
 1.35A 6f3nC-5fqdA:
undetectable		 6f3nC-5fqdA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_1
(-)		 5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A1032
ASP A1092
LEU A 974
LEU A1000
GLY A1001
 None
 1.32A 6f3nD-5fqdA:
undetectable		 6f3nD-5fqdA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens) 		5 / 12 GLN C 198
ASP C 203
ASP C 140
ASP C 157
ILE C 156
 None
 1.37A 6fzbB-5fqdC:
undetectable		 6fzbB-5fqdC:
11.61