SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fql'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 ILE A 492
ASN A 456
PRO A 457
LEU A 548
VAL A 424
 None
 1.38A 1mrlB-5fqlA:
undetectable
1mrlC-5fqlA:
undetectable		 1mrlB-5fqlA:
15.53
1mrlC-5fqlA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 LEU A 413
LEU A 410
VAL A 401
LEU A 359
VAL A 363
 None
 0.96A 1sn5B-5fqlA:
undetectable
1sn5D-5fqlA:
undetectable		 1sn5B-5fqlA:
12.50
1sn5D-5fqlA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 4 LEU A 318
SER A 326
LEU A 221
LEU A 209
 None
NAG  A1560 ( 4.5A)
None
None
 1.15A 1yajA-5fqlA:
undetectable		 1yajA-5fqlA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.21A 2hrcA-5fqlA:
undetectable		 2hrcA-5fqlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.25A 2hrcB-5fqlA:
undetectable		 2hrcB-5fqlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 5 ASP A 252
LEU A 339
GLY A 340
ARG A  48
 None
 0.81A 2j2pA-5fqlA:
undetectable
2j2pB-5fqlA:
undetectable		 2j2pA-5fqlA:
16.42
2j2pB-5fqlA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 4 ASP A 252
LEU A 339
GLY A 340
ARG A  48
 None
 0.84A 2j2pD-5fqlA:
undetectable
2j2pE-5fqlA:
undetectable		 2j2pD-5fqlA:
16.42
2j2pE-5fqlA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.14A 2po5A-5fqlA:
undetectable		 2po5A-5fqlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 11 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.18A 2po5B-5fqlA:
undetectable		 2po5B-5fqlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.09A 2po7A-5fqlA:
undetectable		 2po7A-5fqlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		3 / 3 ARG A 110
SER A 152
TYR A 108
 NAG  A1552 ( 4.9A)
None
NAG  A1555 (-4.0A)
 0.79A 2q2hA-5fqlA:
undetectable
2q2hB-5fqlA:
undetectable		 2q2hA-5fqlA:
14.43
2q2hB-5fqlA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.33A 2qd4A-5fqlA:
undetectable		 2qd4A-5fqlA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 9 TYR A 122
PHE A 123
LEU A 439
LEU A 413
ALA A 414
 None
 1.29A 2vcvE-5fqlA:
undetectable		 2vcvE-5fqlA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 GLY A 343
HIS A 342
ASN A 265
ALA A 250
 None
 0.94A 2x0pA-5fqlA:
2.8		 2x0pA-5fqlA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 GLU A 341
TYR A 264
GLU A 344
ASN A 265
TYR A 348
 None
 1.37A 3ckzA-5fqlA:
undetectable		 3ckzA-5fqlA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		3 / 3 PRO A 243
LEU A 244
GLN A 298
 NAG  A1558 ( 4.6A)
None
None
 0.32A 3hznG-5fqlA:
undetectable
3hznH-5fqlA:
undetectable		 3hznG-5fqlA:
17.29
3hznH-5fqlA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 6 LEU A 377
PHE A 378
ILE A 329
THR A 367
 None
 1.13A 3mdrA-5fqlA:
undetectable		 3mdrA-5fqlA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 LEU A 259
GLY A 520
ALA A 519
ILE A 487
GLY A 489
 None
 0.93A 3nu5B-5fqlA:
undetectable		 3nu5B-5fqlA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 10 LEU A 259
GLY A 520
ALA A 519
ILE A 487
GLY A 489
 None
 0.99A 3oxwC-5fqlA:
undetectable		 3oxwC-5fqlA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 LEU A 259
GLY A 520
ALA A 519
ILE A 487
GLY A 489
 None
 0.95A 3oxxC-5fqlA:
undetectable		 3oxxC-5fqlA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 HIS A 335
LYS A 347
ALA A 346
ASP A  45
 CA  A1551 (-3.3A)
ALS  A  84 ( 2.6A)
None
CA  A1551 (-3.0A)
 0.97A 4k0bB-5fqlA:
undetectable		 4k0bB-5fqlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 HIS A 335
LYS A 347
TYR A 300
ASP A  45
 CA  A1551 (-3.3A)
ALS  A  84 ( 2.6A)
None
CA  A1551 (-3.0A)
 0.84A 4k0bB-5fqlA:
undetectable		 4k0bB-5fqlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 HIS A 335
LYS A 347
ALA A 346
ASP A  45
 CA  A1551 (-3.3A)
ALS  A  84 ( 2.6A)
None
CA  A1551 (-3.0A)
 1.04A 4l7iB-5fqlA:
undetectable		 4l7iB-5fqlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 HIS A 335
LYS A 347
TYR A 300
ASP A  45
 CA  A1551 (-3.3A)
ALS  A  84 ( 2.6A)
None
CA  A1551 (-3.0A)
 0.88A 4l7iB-5fqlA:
undetectable		 4l7iB-5fqlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 6 ASP A  45
ASP A  46
ALA A 346
ASP A 334
 CA  A1551 (-3.0A)
CA  A1551 (-3.0A)
None
CA  A1551 (-2.6A)
 1.21A 4mdbA-5fqlA:
undetectable		 4mdbA-5fqlA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 7 HIS A 229
ASP A  45
LYS A 227
SER A 201
 ALS  A  84 ( 4.0A)
CA  A1551 (-3.0A)
None
None
 1.17A 4odjA-5fqlA:
undetectable		 4odjA-5fqlA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 THR A 202
GLY A 224
GLY A 134
VAL A 133
 None
None
CL  A1567 (-3.7A)
None
 0.82A 4qvvK-5fqlA:
undetectable
4qvvL-5fqlA:
undetectable		 4qvvK-5fqlA:
16.51
4qvvL-5fqlA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 THR A 202
GLY A 224
GLY A 134
VAL A 133
 None
None
CL  A1567 (-3.7A)
None
 0.81A 4qvvY-5fqlA:
undetectable
4qvvZ-5fqlA:
undetectable		 4qvvY-5fqlA:
16.51
4qvvZ-5fqlA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 GLY A 489
ALA A 263
VAL A 503
HIS A 518
ILE A 517
 None
 1.10A 4rvdA-5fqlA:
undetectable		 4rvdA-5fqlA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 5 ILE A  42
HIS A 356
TYR A 300
VAL A 304
 None
 1.34A 4s0vA-5fqlA:
undetectable		 4s0vA-5fqlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 MET A 131
LEU A 221
LEU A 321
LEU A 318
LEU A 314
 None
 1.18A 4zn7A-5fqlA:
undetectable		 4zn7A-5fqlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 TYR A 300
ALA A  82
ALA A  79
LEU A 403
GLY A 336
 None
 1.18A 5jglB-5fqlA:
undetectable		 5jglB-5fqlA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 ALA A 222
LEU A  41
THR A 327
PHE A 219
LEU A 209
 None
 1.19A 5k9dA-5fqlA:
undetectable		 5k9dA-5fqlA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 THR A 355
SER A  87
SER A  90
ASP A  98
 None
ALS  A  84 ( 4.6A)
None
None
 1.07A 5l5fY-5fqlA:
0.0
5l5fZ-5fqlA:
0.0		 5l5fY-5fqlA:
17.99
5l5fZ-5fqlA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 6 ASP A  45
ASP A  46
HIS A 335
HIS A 229
 CA  A1551 (-3.0A)
CA  A1551 (-3.0A)
CA  A1551 (-3.3A)
ALS  A  84 ( 4.0A)
 0.93A 5ncdA-5fqlA:
undetectable
5ncdD-5fqlA:
2.1		 5ncdA-5fqlA:
20.34
5ncdD-5fqlA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 6 ASP A  45
ASP A  46
HIS A 335
HIS A 229
 CA  A1551 (-3.0A)
CA  A1551 (-3.0A)
CA  A1551 (-3.3A)
ALS  A  84 ( 4.0A)
 0.87A 5nelA-5fqlA:
undetectable
5nelD-5fqlA:
undetectable		 5nelA-5fqlA:
20.34
5nelD-5fqlA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 7 GLN A 465
GLY A 489
ILE A 485
GLN A 474
 None
 1.12A 5vlmC-5fqlA:
undetectable		 5vlmC-5fqlA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 GLN A 465
GLY A 489
ILE A 485
GLN A 474
 None
 1.03A 5vlmD-5fqlA:
undetectable		 5vlmD-5fqlA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 ILE A  43
ASP A  45
HIS A 138
PRO A 139
SER A  87
 None
CA  A1551 (-3.0A)
ALS  A  84 ( 3.7A)
None
ALS  A  84 ( 4.6A)
 1.49A 6fbpA-5fqlA:
undetectable
6fbpB-5fqlA:
undetectable		 6fbpA-5fqlA:
9.90
6fbpB-5fqlA:
9.90