SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5frd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 169
ASP A 168
GLY A  31
HIS A  88
GLN A  36
 None
 1.46A 1s9aB-5frdA:
undetectable		 1s9aB-5frdA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		6 / 12 SER A  75
ILE A  49
ILE A  27
LEU A  51
ASN A  53
VAL A  65
 None
 1.48A 2nnhA-5frdA:
undetectable		 2nnhA-5frdA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		4 / 8 VAL A  62
ASP A 168
LEU A  90
HIS A  54
 None
None
CL  A1258 (-4.5A)
None
 0.91A 3af0A-5frdA:
undetectable		 3af0A-5frdA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		4 / 8 PRO A  52
ASN A  53
HIS A  54
GLY A  91
 None
 0.63A 3em0B-5frdA:
undetectable		 3em0B-5frdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 ASN A  53
PHE A 175
GLY A  91
SER A  30
ILE A  49
 None
None
None
CL  A1258 (-2.9A)
None
 1.24A 3iv6A-5frdA:
2.8		 3iv6A-5frdA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		3 / 3 HIS A 228
HIS A  88
MET A 229
 None
 0.89A 3mihA-5frdA:
undetectable		 3mihA-5frdA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 VAL A  86
VAL A 251
LEU A 246
VAL A  80
ALA A  83
 None
 1.08A 3rr3B-5frdA:
undetectable		 3rr3B-5frdA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 VAL A  86
VAL A 251
LEU A 246
VAL A  80
ALA A  83
 None
 1.08A 3rr3C-5frdA:
undetectable		 3rr3C-5frdA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 VAL A  86
VAL A 251
LEU A 246
VAL A  80
ALA A  83
 None
 1.08A 3rr3D-5frdA:
undetectable		 3rr3D-5frdA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 207
LEU A  98
LYS A  97
 COA  A1257 (-3.4A)
None
None
 0.71A 3sueD-5frdA:
undetectable		 3sueD-5frdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		3 / 3 PHE A 158
SER A  29
SER A  30
 None
CL  A1258 ( 4.8A)
CL  A1258 (-2.9A)
 0.87A 3ufgB-5frdA:
undetectable		 3ufgB-5frdA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 188
LEU A 186
GLY A  92
ALA A  95
LEU A 177
 None
 1.04A 3uq6B-5frdA:
4.0		 3uq6B-5frdA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		3 / 3 LEU A 177
ASP A 180
TYR A 181
 None
 0.56A 4qc6B-5frdA:
undetectable		 4qc6B-5frdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 PRO A 204
THR A 203
HIS A  88
SER A  29
GLY A  92
 None
None
None
CL  A1258 ( 4.8A)
None
 1.46A 4ydqB-5frdA:
3.0		 4ydqB-5frdA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 ASP A  50
ALA A  34
GLN A  96
GLY A  91
THR A 114
 None
 1.21A 5hfjC-5frdA:
undetectable		 5hfjC-5frdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 251
SER A  75
LEU A  76
VAL A  85
LEU A  98
 None
 1.28A 5ubbA-5frdA:
undetectable		 5ubbA-5frdA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 HIS A 228
LEU A 118
SER A  30
HIS A  88
ASP A 200
 None
COA  A1257 ( 4.0A)
CL  A1258 (-2.9A)
None
None
 1.23A 6n91A-5frdA:
2.4		 6n91A-5frdA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 5frd CARBOXYLESTERASE
(EST-2)
(Archaeoglobus
fulgidus) 		5 / 12 HIS A 228
LEU A 118
SER A  30
HIS A  88
ASP A 200
 None
COA  A1257 ( 4.0A)
CL  A1258 (-2.9A)
None
None
 1.26A 6n91B-5frdA:
2.2		 6n91B-5frdA:
15.29