SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fsa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 7 LEU A 356
LEU A 359
SER A 361
THR A 365
 None
 0.92A 1dvxA-5fsaA:
undetectable		 1dvxA-5fsaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 7 LEU A 356
LEU A 359
SER A 361
THR A 365
 None
 0.93A 1dvxB-5fsaA:
undetectable		 1dvxB-5fsaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 6 LEU A 356
LEU A 359
SER A 361
THR A 365
 None
 0.98A 1tyrA-5fsaA:
undetectable		 1tyrA-5fsaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 6 ILE A 471
ARG A 469
PRO A 375
SER A 314
 HEM  A 580 (-4.4A)
None
HEM  A 580 (-4.3A)
None
 1.16A 2qd3B-5fsaA:
undetectable		 2qd3B-5fsaA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 7 PHE A 126
TYR A 132
THR A 311
LEU A 376
 X2N  A 590 (-4.8A)
HEM  A 580 (-4.1A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.86A 2wx2A-5fsaA:
37.8		 2wx2A-5fsaA:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 TYR A 118
PHE A 126
TYR A 132
THR A 311
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
HEM  A 580 (-4.1A)
HEM  A 580 (-3.6A)
 0.50A 2wx2B-5fsaA:
36.3		 2wx2B-5fsaA:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 TYR A 118
PHE A 233
TYR A 132
LEU A 376
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.3A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.16A 2x2nD-5fsaA:
39.6		 2x2nD-5fsaA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 TYR A 118
PHE A 233
TYR A 132
THR A 311
LEU A 376
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.3A)
HEM  A 580 (-4.1A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.82A 2x2nD-5fsaA:
39.6		 2x2nD-5fsaA:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 6 ALA A 430
ASN A 364
PRO A 360
ALA A 431
 None
 1.16A 2zgwB-5fsaA:
undetectable		 2zgwB-5fsaA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 6 VAL A 125
ASP A 225
HIS A 310
ASN A 232
 None
 1.39A 2zs9A-5fsaA:
undetectable		 2zs9A-5fsaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 6 LEU A 356
LEU A 359
SER A 361
THR A 365
 None
 0.89A 3cfqA-5fsaA:
undetectable		 3cfqA-5fsaA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		3 / 3 GLU A 102
SER A 453
VAL A 452
 None
 0.61A 3eeoA-5fsaA:
undetectable		 3eeoA-5fsaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 11 ALA A 434
GLY A 465
SER A 436
VAL A 456
SER A 458
 None
 1.10A 3gyqB-5fsaA:
undetectable		 3gyqB-5fsaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		3 / 3 THR A 384
LYS A 287
GLU A 116
 None
 0.96A 3ijdB-5fsaA:
undetectable		 3ijdB-5fsaA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 TYR A 118
THR A 122
TYR A 132
GLY A 303
 X2N  A 590 ( 4.0A)
None
HEM  A 580 (-4.1A)
X2N  A 590 ( 4.8A)
 0.59A 3jusA-5fsaA:
46.1		 3jusA-5fsaA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 TYR A 118
TYR A 132
GLY A 303
THR A 311
 X2N  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
X2N  A 590 ( 4.8A)
HEM  A 580 (-3.6A)
 0.55A 3jusA-5fsaA:
46.1		 3jusA-5fsaA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 TYR A 118
THR A 122
TYR A 132
GLY A 303
 X2N  A 590 ( 4.0A)
None
HEM  A 580 (-4.1A)
X2N  A 590 ( 4.8A)
 0.59A 3jusA-5fsaA:
46.1		 3jusA-5fsaA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 TYR A 118
TYR A 132
GLY A 303
THR A 311
 X2N  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
X2N  A 590 ( 4.8A)
HEM  A 580 (-3.6A)
 0.55A 3jusA-5fsaA:
46.1		 3jusA-5fsaA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 9 TYR A 118
THR A 122
TYR A 132
GLY A 303
THR A 311
 X2N  A 590 ( 4.0A)
None
HEM  A 580 (-4.1A)
X2N  A 590 ( 4.8A)
HEM  A 580 (-3.6A)
 0.63A 3jusB-5fsaA:
46.0		 3jusB-5fsaA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 PHE A 126
TYR A 132
THR A 311
LEU A 376
 X2N  A 590 (-4.8A)
HEM  A 580 (-4.1A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.88A 3khmA-5fsaA:
35.7		 3khmA-5fsaA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 9 TYR A 118
TYR A 132
THR A 311
LEU A 376
MET A 508
 X2N  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 0.78A 3l4dC-5fsaA:
39.0		 3l4dC-5fsaA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		6 / 12 TYR A 118
PHE A 126
TYR A 132
PHE A 228
GLY A 303
THR A 311
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 ( 4.8A)
HEM  A 580 (-3.6A)
 0.94A 3ld6A-5fsaA:
46.5		 3ld6A-5fsaA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		6 / 12 TYR A 118
PHE A 126
TYR A 132
PHE A 228
GLY A 303
THR A 311
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 ( 4.8A)
HEM  A 580 (-3.6A)
 0.97A 3ld6B-5fsaA:
46.3		 3ld6B-5fsaA:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 ASN A 106
GLY A 464
SER A 436
VAL A 456
SER A 458
 None
HEM  A 580 ( 4.2A)
None
None
None
 1.05A 3nk7A-5fsaA:
undetectable		 3nk7A-5fsaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 10 PHE A 380
VAL A  94
PHE A  85
PHE A  71
GLY A  65
 X2N  A 590 ( 4.8A)
None
None
None
X2N  A 590 ( 4.0A)
 1.38A 3r6wA-5fsaA:
undetectable
3r6wB-5fsaA:
undetectable		 3r6wA-5fsaA:
18.76
3r6wB-5fsaA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 THR A 365
LEU A 320
LEU A 323
ILE A 366
VAL A 362
 None
 1.06A 4c9lB-5fsaA:
25.7		 4c9lB-5fsaA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 THR A 365
LEU A 320
LEU A 323
ILE A 366
VAL A 362
 None
 1.07A 4c9oB-5fsaA:
25.7		 4c9oB-5fsaA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 6 GLY A 481
ILE A 483
GLN A 479
VAL A 159
 None
 1.04A 4d39B-5fsaA:
undetectable		 4d39B-5fsaA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 ILE A 270
ILE A 261
ILE A 277
ASP A 275
 None
 0.86A 4dtaB-5fsaA:
undetectable		 4dtaB-5fsaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 6 LEU A 356
LEU A 359
SER A 361
THR A 365
 None
 1.01A 4ikiB-5fsaA:
undetectable		 4ikiB-5fsaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 7 LEU A 356
LEU A 359
SER A 361
THR A 365
 None
 0.91A 4iklA-5fsaA:
undetectable
4iklB-5fsaA:
undetectable		 4iklA-5fsaA:
15.91
4iklB-5fsaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 LEU A 356
LEU A 359
SER A 361
THR A 365
 None
 0.95A 4iklA-5fsaA:
undetectable
4iklB-5fsaA:
undetectable		 4iklA-5fsaA:
15.91
4iklB-5fsaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 6 GLY A 481
ILE A 483
GLN A 479
VAL A 159
 None
 1.07A 4kcnA-5fsaA:
undetectable		 4kcnA-5fsaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		3 / 3 TYR A 415
GLY A  97
PRO A  98
 None
 0.53A 4qwpA-5fsaA:
undetectable		 4qwpA-5fsaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 6 ALA A 409
GLY A 100
SER A 438
VAL A 456
 None
 0.75A 4r21A-5fsaA:
32.9		 4r21A-5fsaA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 GLY A 465
GLY A 466
PHE A 463
ASN A 435
PRO A 462
 None
None
HEM  A 580 ( 4.5A)
None
None
 1.04A 4rtmA-5fsaA:
undetectable		 4rtmA-5fsaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 7 LEU A 359
GLU A 336
SER A 361
ILE A 333
 None
 1.22A 4tvtA-5fsaA:
undetectable		 4tvtA-5fsaA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		3 / 3 MET A 292
GLU A 296
LEU A 300
 None
 0.28A 4v2oB-5fsaA:
undetectable		 4v2oB-5fsaA:
10.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		9 / 9 TYR A 118
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 307
THR A 311
LEU A 376
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 0.68A 4wmzA-5fsaA:
34.5		 4wmzA-5fsaA:
59.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		11 / 12 GLY A  65
TYR A 118
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.57A 4zdyA-5fsaA:
56.9		 4zdyA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 GLY A 308
THR A 311
LEU A 376
HIS A 377
MET A 508
 HEM  A 580 (-3.6A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.00A 4zdyA-5fsaA:
56.9		 4zdyA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		3 / 3 ALA A  61
TYR A  64
PRO A 230
 X2N  A 590 (-3.5A)
None
X2N  A 590 (-4.2A)
 0.27A 4zdyA-5fsaA:
56.9		 4zdyA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		7 / 7 PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
MET A 508
 X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 0.71A 4zdzA-5fsaA:
56.6		 4zdzA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		8 / 9 TYR A 118
THR A 122
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
 X2N  A 590 ( 4.0A)
None
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.61A 4ze0A-5fsaA:
57.2		 4ze0A-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		10 / 12 TYR A  64
GLY A  65
LEU A 121
PHE A 126
PHE A 228
GLY A 307
LEU A 376
HIS A 377
PHE A 380
MET A 508
 None
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.6A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.54A 4ze1A-5fsaA:
56.9		 4ze1A-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 5 TYR A 118
ILE A 131
PRO A 230
THR A 311
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.2A)
HEM  A 580 (-3.6A)
 0.30A 4ze1A-5fsaA:
56.9		 4ze1A-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		11 / 12 GLY A  65
TYR A 118
LEU A 121
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
HIS A 377
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.6A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 0.54A 4ze2A-5fsaA:
57.2		 4ze2A-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 GLY A 308
THR A 311
LEU A 376
HIS A 377
MET A 508
 HEM  A 580 (-3.6A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.07A 4ze2A-5fsaA:
57.2		 4ze2A-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 5 ALA A  61
TYR A  64
PRO A 230
PHE A 380
 X2N  A 590 (-3.5A)
None
X2N  A 590 (-4.2A)
X2N  A 590 ( 4.8A)
 0.41A 4ze2A-5fsaA:
57.2		 4ze2A-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		7 / 7 TYR A 118
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.51A 4ze3A-5fsaA:
57.7		 4ze3A-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 11 VAL A 478
PHE A 463
GLY A 308
GLY A 307
ILE A 304
 None
HEM  A 580 ( 4.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-3.5A)
HEM  A 580 ( 4.6A)
 1.19A 4zvmA-5fsaA:
undetectable
4zvmB-5fsaA:
undetectable		 4zvmA-5fsaA:
19.31
4zvmB-5fsaA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		3 / 3 THR A 196
THR A 199
PHE A 205
 None
 0.86A 5cxvA-5fsaA:
undetectable		 5cxvA-5fsaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 HIS A 310
GLY A 307
PHE A 228
LEU A 224
TYR A 221
 None
X2N  A 590 (-3.5A)
X2N  A 590 (-4.9A)
None
None
 1.24A 5eeiA-5fsaA:
undetectable		 5eeiA-5fsaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 HIS A 310
GLY A 307
PHE A 228
LEU A 224
TYR A 221
 None
X2N  A 590 (-3.5A)
X2N  A 590 (-4.9A)
None
None
 1.24A 5eeiB-5fsaA:
undetectable		 5eeiB-5fsaA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 GLY A  65
GLY A 308
LEU A 376
HIS A 377
MET A 508
 X2N  A 590 ( 4.0A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.02A 5eqbA-5fsaA:
57.0		 5eqbA-5fsaA:
59.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		11 / 12 GLY A  65
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 303
GLY A 307
LEU A 376
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-3.5A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.59A 5eqbA-5fsaA:
57.0		 5eqbA-5fsaA:
59.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 4 TYR A  64
TYR A 118
PRO A 230
THR A 311
 None
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.2A)
HEM  A 580 (-3.6A)
 0.42A 5eqbA-5fsaA:
57.0		 5eqbA-5fsaA:
59.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 GLY A 308
THR A 311
LEU A 376
HIS A 377
MET A 508
 HEM  A 580 (-3.6A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.10A 5esgA-5fsaA:
57.3		 5esgA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		11 / 12 TYR A  64
PHE A 126
ILE A 131
TYR A 132
PHE A 228
VAL A 234
GLY A 307
THR A 311
LEU A 376
HIS A 377
MET A 508
 None
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
None
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 0.56A 5esgA-5fsaA:
57.3		 5esgA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 4 LEU A  88
TYR A 118
PRO A 230
ILE A 231
 None
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.2A)
None
 0.35A 5esgA-5fsaA:
57.3		 5esgA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		8 / 12 ALA A  61
LEU A  87
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 307
MET A 508
 X2N  A 590 (-3.5A)
None
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
X2N  A 590 (-4.8A)
 1.32A 5eshA-5fsaA:
57.7		 5eshA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		12 / 12 ALA A  61
LEU A  88
TYR A 118
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 307
THR A 311
LEU A 376
PHE A 380
MET A 508
 X2N  A 590 (-3.5A)
None
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.75A 5eshA-5fsaA:
57.7		 5eshA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		11 / 12 GLY A  65
TYR A 118
LEU A 121
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 307
THR A 311
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.6A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.43A 5eskA-5fsaA:
56.0		 5eskA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 LEU A 121
TYR A 118
PHE A 228
GLY A 307
THR A 311
 X2N  A 590 (-4.6A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
 1.18A 5eskA-5fsaA:
56.0		 5eskA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 4 ALA A  61
PRO A 230
LEU A 376
HIS A 377
 X2N  A 590 (-3.5A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
 0.44A 5eskA-5fsaA:
56.0		 5eskA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		11 / 12 GLY A  65
TYR A 118
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 307
THR A 311
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.49A 5eslA-5fsaA:
57.3		 5eslA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 5 ALA A  61
TYR A  64
PRO A 230
GLY A 303
LEU A 376
 X2N  A 590 (-3.5A)
None
X2N  A 590 (-4.2A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.3A)
 0.52A 5eslA-5fsaA:
57.3		 5eslA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		7 / 7 TYR A 118
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.63A 5esmA-5fsaA:
55.8		 5esmA-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 9 LEU A 480
THR A 315
LEU A 320
PRO A 512
LEU A 321
 None
HEM  A 580 ( 4.6A)
None
None
None
 1.43A 5g48B-5fsaA:
undetectable		 5g48B-5fsaA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		6 / 8 PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
 X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.63A 5hs1A-5fsaA:
55.8		 5hs1A-5fsaA:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		6 / 8 TYR A 118
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
 0.39A 5hs1A-5fsaA:
55.8		 5hs1A-5fsaA:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		6 / 12 ALA A  61
PHE A 228
GLY A 308
THR A 311
HIS A 377
MET A 508
 X2N  A 590 (-3.5A)
X2N  A 590 (-4.9A)
HEM  A 580 (-3.6A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.00A 5jlcA-5fsaA:
54.7		 5jlcA-5fsaA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		11 / 12 ALA A  61
TYR A 118
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 307
THR A 311
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 (-3.5A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.53A 5jlcA-5fsaA:
54.7		 5jlcA-5fsaA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 TYR A 132
PHE A 126
PHE A 228
GLY A 307
THR A 311
 HEM  A 580 (-4.1A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
 1.18A 5jlcA-5fsaA:
54.7		 5jlcA-5fsaA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 5 TYR A  64
GLY A  65
GLY A 303
LEU A 376
 None
X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.3A)
 0.47A 5jlcA-5fsaA:
54.7		 5jlcA-5fsaA:
62.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 ASP A 207
GLY A 206
LEU A 276
ALA A 149
PHE A 475
 None
 1.35A 5kc4E-5fsaA:
1.9		 5kc4E-5fsaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 THR A 369
TYR A 477
PHE A 463
PRO A 462
 None
None
HEM  A 580 ( 4.5A)
None
 1.23A 5v4vA-5fsaA:
undetectable		 5v4vA-5fsaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 THR A 369
TYR A 477
PHE A 463
PRO A 462
 None
None
HEM  A 580 ( 4.5A)
None
 1.25A 5v4vB-5fsaA:
undetectable		 5v4vB-5fsaA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		12 / 12 TYR A 118
PHE A 126
ILE A 131
TYR A 132
PHE A 228
PHE A 233
GLY A 307
THR A 311
LEU A 376
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-4.3A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.56A 5v5zA-5fsaA:
54.9		 5v5zA-5fsaA:
90.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		3 / 3 GLY A  65
THR A 122
PRO A 230
 X2N  A 590 ( 4.0A)
None
X2N  A 590 (-4.2A)
 0.48A 5v5zA-5fsaA:
54.9		 5v5zA-5fsaA:
90.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 MET A 189
GLN A 192
ALA A 313
SER A 316
LEU A 320
 None
 1.19A 5vlmA-5fsaA:
undetectable		 5vlmA-5fsaA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 ASN A 232
LEU A 121
VAL A 125
ASP A 225
LEU A 511
 None
X2N  A 590 (-4.6A)
None
None
None
 1.24A 5x24A-5fsaA:
30.4		 5x24A-5fsaA:
25.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 10 TYR A 118
PHE A 126
PHE A 228
THR A 311
LEU A 376
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.9A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 1.40A 6ay4A-5fsaA:
40.6		 6ay4A-5fsaA:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 10 TYR A 118
PHE A 126
THR A 311
LEU A 376
CYH A 470
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
HEM  A 580 (-2.2A)
 0.86A 6ay4A-5fsaA:
40.6		 6ay4A-5fsaA:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 10 TYR A 118
TYR A 132
PHE A 228
THR A 311
LEU A 376
 X2N  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 1.23A 6ay4A-5fsaA:
40.6		 6ay4A-5fsaA:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 10 TYR A 118
TYR A 132
THR A 311
LEU A 376
CYH A 470
 X2N  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
HEM  A 580 (-2.2A)
 0.66A 6ay4A-5fsaA:
40.6		 6ay4A-5fsaA:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		6 / 9 TYR A 118
PHE A 126
TYR A 132
THR A 311
LEU A 376
CYH A 470
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
HEM  A 580 (-4.1A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
HEM  A 580 (-2.2A)
 0.73A 6ay6A-5fsaA:
43.5		 6ay6A-5fsaA:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 TYR A 118
PHE A 126
TYR A 132
THR A 311
LEU A 376
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
HEM  A 580 (-4.1A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.84A 6aybA-5fsaA:
43.4		 6aybA-5fsaA:
36.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 ALA A  61
TYR A 118
PHE A 126
TYR A 132
LEU A 376
 X2N  A 590 (-3.5A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.3A)
 0.92A 6aycA-5fsaA:
43.8		 6aycA-5fsaA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		5 / 12 TYR A 118
PHE A 126
TYR A 132
THR A 311
LEU A 376
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
HEM  A 580 (-4.1A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.78A 6aycA-5fsaA:
43.8		 6aycA-5fsaA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 LEU A 480
TYR A 477
GLU A 473
THR A 315
 None
None
None
HEM  A 580 ( 4.6A)
 1.24A 6c71B-5fsaA:
undetectable		 6c71B-5fsaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		11 / 12 GLY A  65
TYR A 118
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.52A 6e8qA-5fsaA:
57.2		 6e8qA-5fsaA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 4 TYR A  64
LEU A 121
TYR A 132
PRO A 230
 None
X2N  A 590 (-4.6A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.2A)
 0.37A 6e8qA-5fsaA:
57.2		 6e8qA-5fsaA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		4 / 8 GLY A  65
GLN A  66
PHE A  72
TYR A  69
 X2N  A 590 ( 4.0A)
None
None
None
 1.10A 6eqpA-5fsaA:
undetectable		 6eqpA-5fsaA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		3 / 3 ASN A 237
PRO A 124
GLN A 250
 None
 0.95A 6jnhA-5fsaA:
undetectable		 6jnhA-5fsaA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5fsa CYP51 VARIANT1
(Candida
albicans) 		3 / 3 ASN A 237
PRO A 124
GLN A 250
 None
 0.93A 6jogA-5fsaA:
undetectable		 6jogA-5fsaA:
15.37