SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		4 / 8 GLY A  16
GLY A 127
SER A 167
GLY A 129
 None
 0.77A 1d0vA-5fsbA:
undetectable		 1d0vA-5fsbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		4 / 8 GLY A  91
GLY A 205
SER A  14
GLY A 207
 None
 0.71A 1d0vA-5fsbA:
undetectable		 1d0vA-5fsbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		4 / 8 GLY A  16
GLY A 127
SER A 167
GLY A 129
 None
 0.77A 1jhaA-5fsbA:
undetectable		 1jhaA-5fsbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		4 / 8 GLY A  91
GLY A 205
SER A  14
GLY A 207
 None
 0.71A 1jhaA-5fsbA:
undetectable		 1jhaA-5fsbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		4 / 8 ASP A 125
SER A 167
GLY A 129
GLY A  52
 MG  A 299 ( 3.9A)
None
None
None
 0.85A 1jr1B-5fsbA:
undetectable		 1jr1B-5fsbA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		4 / 8 ASP A 203
SER A  14
GLY A 207
GLY A 127
 MG  A 299 ( 3.9A)
None
None
None
 0.83A 1jr1B-5fsbA:
undetectable		 1jr1B-5fsbA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		3 / 3 GLN A  43
ILE A  30
TYR A  31
 None
None
6YR  A 300 (-3.8A)
 0.73A 1vifA-5fsbA:
undetectable		 1vifA-5fsbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		3 / 3 GLN A  80
ILE A  68
TYR A  69
 None
None
6YR  A 301 (-3.9A)
 0.72A 1vifA-5fsbA:
undetectable		 1vifA-5fsbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		3 / 3 GLN A 118
ILE A 105
TYR A 106
 None
None
6YR  A 302 (-3.9A)
 0.76A 1vifA-5fsbA:
undetectable		 1vifA-5fsbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		5 / 12 ILE A 221
GLY A 220
GLY A 218
LEU A 201
GLY A 214
 None
SO4  A 312 (-3.5A)
SO4  A 312 (-3.2A)
None
None
 0.92A 2fk8A-5fsbA:
undetectable		 2fk8A-5fsbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		3 / 3 GLY A 169
GLY A  91
GLY A 129
 None
 0.40A 3bogC-5fsbA:
undetectable		 3bogC-5fsbA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		5 / 11 LEU A  48
ARG A  12
ILE A  88
GLY A  52
SER A  14
 6YR  A 301 ( 4.6A)
SO4  A 310 ( 2.9A)
None
None
None
 1.33A 3bpxA-5fsbA:
undetectable
3bpxB-5fsbA:
undetectable		 3bpxA-5fsbA:
19.30
3bpxB-5fsbA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		5 / 11 VAL A 134
GLY A 136
TYR A 144
ALA A 104
TYR A 106
 None
None
6YR  A 303 (-3.9A)
None
6YR  A 302 (-3.9A)
 1.36A 3qxyB-5fsbA:
undetectable
3qxyQ-5fsbA:
undetectable		 3qxyB-5fsbA:
16.34
3qxyQ-5fsbA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		4 / 8 ASP A 125
SER A  89
ARG A  87
GLY A 205
 MG  A 299 ( 3.9A)
None
None
None
 0.98A 4af0A-5fsbA:
undetectable		 4af0A-5fsbA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WZM_A_ACTA503_0
(RNA DEPENDENT RNA
POLYMERASE)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		4 / 4 ASP A 203
ASP A 125
ASP A  50
ALA A 165
 MG  A 299 ( 3.9A)
MG  A 299 ( 3.9A)
MG  A 299 ( 4.0A)
None
 1.11A 4wzmA-5fsbA:
undetectable		 4wzmA-5fsbA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		4 / 7 GLY A   5
TRP A 224
TRP A   3
TYR A  33
 None
 1.17A 5vlmG-5fsbA:
undetectable		 5vlmG-5fsbA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		5 / 10 SER A  89
ASP A 131
ILE A 204
SER A  14
GLY A 205
 None
 1.26A 5weoA-5fsbA:
undetectable
5weoD-5fsbA:
undetectable		 5weoA-5fsbA:
12.57
5weoD-5fsbA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		5 / 9 ALA A  53
SER A  14
GLY A  16
ALA A 128
GLY A 169
 None
 0.93A 6bklE-5fsbA:
undetectable
6bklF-5fsbA:
undetectable
6bklG-5fsbA:
undetectable
6bklH-5fsbA:
undetectable		 6bklE-5fsbA:
6.93
6bklF-5fsbA:
6.93
6bklG-5fsbA:
6.93
6bklH-5fsbA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		5 / 9 ALA A 128
SER A  89
GLY A  91
ALA A 206
GLY A  16
 None
 1.08A 6bklE-5fsbA:
undetectable
6bklF-5fsbA:
undetectable
6bklG-5fsbA:
undetectable
6bklH-5fsbA:
undetectable		 6bklE-5fsbA:
6.93
6bklF-5fsbA:
6.93
6bklG-5fsbA:
6.93
6bklH-5fsbA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 5fsb TECTONIN 2
(Laccaria
bicolor) 		5 / 9 ALA A 206
SER A 167
GLY A 169
ALA A  53
GLY A  91
 None
 1.09A 6bklE-5fsbA:
undetectable
6bklF-5fsbA:
undetectable
6bklG-5fsbA:
undetectable
6bklH-5fsbA:
undetectable		 6bklE-5fsbA:
6.93
6bklF-5fsbA:
6.93
6bklG-5fsbA:
6.93
6bklH-5fsbA:
6.93