SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fse'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 GLU C 120
ILE C 122
LEU C 437
ILE C 451
THR C 482
None
1.23A 1d1gA-5fseC:
undetectable
1d1gA-5fseC:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 GLU C 120
ILE C 122
LEU C 437
ILE C 451
THR C 482
None
1.20A 1d1gB-5fseC:
undetectable
1d1gB-5fseC:
14.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 5 HIS C 137
HIS C 222
HIS C 249
HIS C 275
ASP C 363
NI  C 601 ( 3.2A)
KCX  C 220 ( 4.1A)
NI  C 600 ( 3.2A)
NI  C 600 ( 3.3A)
NI  C 601 ( 2.6A)
0.40A 1e9yB-5fseC:
64.9
1e9yB-5fseC:
61.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FWE_C_HAEC989_1
(UREASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
6 / 6 HIS C 137
HIS C 139
HIS C 222
HIS C 249
HIS C 275
ASP C 363
NI  C 601 ( 3.2A)
NI  C 601 (-3.5A)
KCX  C 220 ( 4.1A)
NI  C 600 ( 3.2A)
NI  C 600 ( 3.3A)
NI  C 601 ( 2.6A)
0.30A 1fweC-5fseC:
60.8
1fweC-5fseC:
64.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 LEU C 236
LEU C 219
ALA C 214
ALA C 216
VAL C 246
None
KCX  C 220 ( 4.0A)
None
None
None
1.17A 1kt4A-5fseC:
undetectable
1kt4A-5fseC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 ASN C  73
LEU C  70
THR C 110
VAL C 109
ALA C  85
None
1.18A 1n5xA-5fseC:
undetectable
1n5xA-5fseC:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 ASN C  73
LEU C  70
THR C 110
VAL C 109
ALA C  85
None
1.18A 1n5xB-5fseC:
undetectable
1n5xB-5fseC:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 7 GLY C 218
THR C 174
ILE C 180
GLY C 198
None
0.84A 1usqA-5fseC:
undetectable
1usqA-5fseC:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 10 ASP C 251
GLY C 280
GLY C 281
PHE C 335
HIS C 323
None
None
None
None
SO4  C1579 (-3.4A)
1.21A 1w76B-5fseC:
undetectable
1w76B-5fseC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 GLY C 226
ALA C 227
ASP C 251
ILE C 248
ILE C 221
None
None
None
None
KCX  C 220 ( 4.2A)
0.97A 2hs1A-5fseC:
undetectable
2hs1A-5fseC:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 7 GLY C 218
THR C 174
ILE C 180
GLY C 198
None
0.87A 2jklA-5fseC:
undetectable
2jklA-5fseC:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 7 GLY C 218
THR C 174
ILE C 180
GLY C 198
None
0.87A 2jklC-5fseC:
undetectable
2jklC-5fseC:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 7 GLY C 218
THR C 174
ILE C 180
GLY C 198
None
0.88A 2jklD-5fseC:
undetectable
2jklD-5fseC:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 SER C 496
THR C 136
ILE C 420
PHE C 158
HIS C 272
None
1.47A 2vdyA-5fseC:
undetectable
2vdyA-5fseC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 SER C 496
THR C 136
ILE C 420
PHE C 158
HIS C 272
None
1.45A 2vdyB-5fseC:
undetectable
2vdyB-5fseC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
3 / 3 ASP C 363
HIS C 275
HIS C 137
NI  C 601 ( 2.6A)
NI  C 600 ( 3.3A)
NI  C 601 ( 3.2A)
0.70A 2xxgA-5fseC:
undetectable
2xxgA-5fseC:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
3 / 3 ASP C 363
HIS C 275
HIS C 137
NI  C 601 ( 2.6A)
NI  C 600 ( 3.3A)
NI  C 601 ( 3.2A)
0.70A 2xxgC-5fseC:
undetectable
2xxgC-5fseC:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 6 ARG C 402
ARG C 388
ILE C 350
TYR C 406
None
SO4  C1588 ( 3.9A)
HQE  C1583 ( 4.9A)
None
1.15A 2yfbB-5fseC:
undetectable
2yfbB-5fseC:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 GLY C  53
GLY C 101
GLY C  55
ASP C  40
ASN C  57
None
0.99A 2zbpA-5fseC:
undetectable
2zbpA-5fseC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 GLN C 211
THR C 174
THR C 493
LEU C 508
None
1.34A 2zj0A-5fseC:
3.4
2zj0A-5fseC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
3 / 3 MET C 367
GLU C 223
ASN C 254
SO4  C1579 ( 4.3A)
SO4  C1579 ( 4.5A)
None
0.82A 3a27A-5fseC:
undetectable
3a27A-5fseC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 GLN C 211
THR C 174
THR C 493
LEU C 508
None
1.35A 3ce6A-5fseC:
3.3
3ce6A-5fseC:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 GLN C 211
THR C 174
THR C 493
LEU C 508
None
1.31A 3ce6C-5fseC:
3.5
3ce6C-5fseC:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 9 ALA C 217
PHE C 158
SER C 499
LEU C 510
ILE C 514
None
None
None
None
EDO  C1576 ( 4.2A)
1.45A 3claA-5fseC:
undetectable
3claA-5fseC:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 VAL C 450
ILE C 134
ASP C 135
ASN C 491
ILE C 492
None
1.12A 3ddyA-5fseC:
undetectable
3ddyA-5fseC:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 8 GLY C 226
ALA C 227
ASP C 251
ILE C 221
None
None
None
KCX  C 220 ( 4.2A)
0.64A 3el0A-5fseC:
undetectable
3el0A-5fseC:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 10 ILE C 134
VAL C 374
GLY C 371
VAL C 450
LEU C 157
None
1.12A 3elzC-5fseC:
undetectable
3elzC-5fseC:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 LEU C 259
ALA C 284
GLY C 257
ILE C 287
SER C 250
None
1.11A 3gyqA-5fseC:
undetectable
3gyqB-5fseC:
undetectable
3gyqA-5fseC:
17.71
3gyqB-5fseC:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 11 LEU C 259
ALA C 284
GLY C 257
ILE C 287
SER C 250
None
1.09A 3gyqB-5fseC:
undetectable
3gyqB-5fseC:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 GLY C 226
ALA C 227
ASP C 251
VAL C 246
ILE C 221
None
None
None
None
KCX  C 220 ( 4.2A)
1.08A 3ndxA-5fseC:
undetectable
3ndxA-5fseC:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 10 GLY C 226
ALA C 227
ASP C 251
LEU C 219
ILE C 221
None
None
None
KCX  C 220 ( 4.0A)
KCX  C 220 ( 4.2A)
0.87A 3ttpA-5fseC:
undetectable
3ttpA-5fseC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 10 GLY C 226
ALA C 227
ASP C 251
LEU C 219
ILE C 221
None
None
None
KCX  C 220 ( 4.0A)
KCX  C 220 ( 4.2A)
0.85A 3ttpB-5fseC:
undetectable
3ttpB-5fseC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 8 VAL C 504
LEU C 508
LEU C 510
ILE C 180
None
0.89A 3u5kA-5fseC:
undetectable
3u5kA-5fseC:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 PRO C 175
GLY C 167
SER C 168
THR C 162
ASP C 224
None
None
None
None
SO4  C1579 ( 3.7A)
1.19A 3v8vA-5fseC:
2.3
3v8vA-5fseC:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 ASP C  78
GLY C 425
TYR C  79
GLU C 428
None
0.97A 3w9tA-5fseC:
undetectable
3w9tA-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 ASP C 399
SER C 398
GLY C 397
ASP C  26
None
1.46A 3w9tB-5fseC:
undetectable
3w9tB-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 6 ASP C  78
GLY C 425
TYR C  79
GLU C 428
None
0.96A 3w9tB-5fseC:
undetectable
3w9tB-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 ASP C  78
GLY C 425
TYR C  79
GLU C 428
None
0.96A 3w9tC-5fseC:
undetectable
3w9tC-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 ASP C 399
SER C 398
GLY C 397
ASP C  26
None
1.47A 3w9tC-5fseC:
undetectable
3w9tC-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 ASP C  78
GLY C 425
TYR C  79
GLU C 428
None
0.96A 3w9tD-5fseC:
undetectable
3w9tD-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 6 ASP C  78
GLY C 425
TYR C  79
GLU C 428
None
0.97A 3w9tE-5fseC:
undetectable
3w9tE-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 6 ASP C  78
GLY C 425
TYR C  79
GLU C 428
None
0.97A 3w9tF-5fseC:
undetectable
3w9tF-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 ASP C  78
GLY C 425
TYR C  79
GLU C 428
None
0.97A 3w9tG-5fseC:
undetectable
3w9tG-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 VAL C 504
LEU C 508
LEU C 510
ILE C 180
None
0.94A 4a9jC-5fseC:
undetectable
4a9jC-5fseC:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 SER C 496
THR C 136
ILE C 420
PHE C 158
HIS C 272
None
1.26A 4c49A-5fseC:
undetectable
4c49A-5fseC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 SER C 496
THR C 136
ILE C 420
PHE C 158
HIS C 272
None
1.41A 4c49B-5fseC:
undetectable
4c49B-5fseC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 6 LEU C 508
LEU C 510
ILE C 514
MET C 495
THR C 187
None
None
EDO  C1576 ( 4.2A)
None
None
1.50A 4do3B-5fseC:
undetectable
4do3B-5fseC:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H9M_A_HAEA929_1
(UREASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 5 HIS C 137
HIS C 222
HIS C 249
HIS C 275
ASP C 363
NI  C 601 ( 3.2A)
KCX  C 220 ( 4.1A)
NI  C 600 ( 3.2A)
NI  C 600 ( 3.3A)
NI  C 601 ( 2.6A)
0.26A 4h9mA-5fseC:
63.0
4h9mA-5fseC:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 GLY C  55
GLY C  53
ALA C  42
MET C 106
ASP C  40
None
0.80A 4kicA-5fseC:
undetectable
4kicA-5fseC:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 GLY C  55
GLY C  53
ALA C  42
MET C 106
ASP C  40
None
0.81A 4kicB-5fseC:
undetectable
4kicB-5fseC:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 8 HIS C 275
ALA C 247
SER C 361
ASP C 363
NI  C 600 ( 3.3A)
KCX  C 220 ( 4.0A)
None
NI  C 601 ( 2.6A)
1.07A 4l7iB-5fseC:
undetectable
4l7iB-5fseC:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 VAL C 424
ALA C 421
PHE C 494
GLY C 419
ASP C 434
None
1.18A 4mm4A-5fseC:
undetectable
4mm4A-5fseC:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 VAL C 424
ALA C 421
GLY C 195
GLY C 419
ASP C 434
None
1.01A 4mm8A-5fseC:
undetectable
4mm8A-5fseC:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 11 VAL C 424
ALA C 421
GLY C 195
GLY C 419
ASP C 434
None
1.05A 4mm9A-5fseC:
undetectable
4mm9A-5fseC:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 9 VAL C 424
ALA C 421
GLY C 195
PHE C 494
GLY C 419
None
1.04A 4mmeB-5fseC:
undetectable
4mmeB-5fseC:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 ALA C   9
GLY C  13
ASP C 399
ASP C  18
None
0.94A 4n48A-5fseC:
undetectable
4n48A-5fseC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 TYR C  79
ALA C 421
GLY C 425
ASN C 413
GLY C 419
None
1.32A 4obwD-5fseC:
undetectable
4obwD-5fseC:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 VAL C 246
ILE C 271
SER C 273
SER C 299
HIS C 201
None
None
None
None
KCX  C 220 ( 4.6A)
1.33A 4rujA-5fseC:
undetectable
4rujA-5fseC:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 THR C 171
ILE C 208
GLY C 200
ALA C 247
ILE C 212
None
None
KCX  C 220 ( 3.2A)
KCX  C 220 ( 4.0A)
None
1.03A 4rvgA-5fseC:
undetectable
4rvgA-5fseC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 GLY C 200
ASP C 233
ILE C 232
ALA C 227
ARG C 269
KCX  C 220 ( 3.2A)
None
None
None
None
1.10A 4u8vB-5fseC:
undetectable
4u8vB-5fseC:
20.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
6 / 6 HIS C 137
HIS C 139
HIS C 222
HIS C 249
HIS C 275
ASP C 363
NI  C 601 ( 3.2A)
NI  C 601 (-3.5A)
KCX  C 220 ( 4.1A)
NI  C 600 ( 3.2A)
NI  C 600 ( 3.3A)
NI  C 601 ( 2.6A)
0.21A 4ubpC-5fseC:
75.7
4ubpC-5fseC:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 GLY C 226
THR C 228
HIS C 201
GLY C 202
None
None
KCX  C 220 ( 4.6A)
None
1.09A 4v20A-5fseC:
undetectable
4v20A-5fseC:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 8 LEU C 435
ALA C 433
ILE C  94
ALA C 124
None
0.71A 4wboB-5fseC:
undetectable
4wboB-5fseC:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 ILE C 134
GLY C 425
ALA C 415
PHE C 494
THR C 136
None
1.13A 4xt8A-5fseC:
undetectable
4xt8A-5fseC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 8 ALA C 279
HIS C 323
HIS C 249
THR C 252
None
SO4  C1579 (-3.4A)
NI  C 600 ( 3.2A)
None
1.26A 5db5A-5fseC:
undetectable
5db5B-5fseC:
undetectable
5db5A-5fseC:
23.64
5db5B-5fseC:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 4 LEU C  70
ILE C 122
GLY C  88
ILE C 451
None
0.88A 5dzk3-5fseC:
undetectable
5dzkm-5fseC:
2.3
5dzk3-5fseC:
2.86
5dzkm-5fseC:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 ILE C 122
GLY C  88
ILE C 451
LEU C  70
None
0.82A 5dzkB-5fseC:
undetectable
5dzkI-5fseC:
undetectable
5dzkW-5fseC:
undetectable
5dzkB-5fseC:
17.28
5dzkI-5fseC:
15.72
5dzkW-5fseC:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 5 ILE C 122
GLY C  88
ILE C 451
LEU C  70
None
0.85A 5dzki-5fseC:
undetectable
5dzkj-5fseC:
2.2
5dzkx-5fseC:
undetectable
5dzki-5fseC:
15.72
5dzkj-5fseC:
15.72
5dzkx-5fseC:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 4 ILE C 122
GLY C  88
ILE C 451
LEU C  70
None
0.85A 5dzkl-5fseC:
1.9
5dzkz-5fseC:
undetectable
5dzkl-5fseC:
15.72
5dzkz-5fseC:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 11 ASP C 147
VAL C 483
ILE C 487
ILE C 192
ILE C 461
None
1.17A 5hw8A-5fseC:
undetectable
5hw8D-5fseC:
undetectable
5hw8A-5fseC:
12.04
5hw8D-5fseC:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 8 ILE C 427
ASP C  78
GLY C 132
THR C 411
None
0.96A 5hwaA-5fseC:
undetectable
5hwaA-5fseC:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
3 / 3 GLY C  39
ASP C  40
ASN C 102
None
0.62A 5jglA-5fseC:
undetectable
5jglA-5fseC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 7 HIS C 272
ILE C 271
VAL C 270
GLN C 418
None
1.16A 5kkzC-5fseC:
undetectable
5kkzE-5fseC:
undetectable
5kkzC-5fseC:
17.65
5kkzE-5fseC:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 7 HIS C 272
ILE C 271
VAL C 270
GLN C 418
None
1.18A 5kkzK-5fseC:
undetectable
5kkzQ-5fseC:
undetectable
5kkzK-5fseC:
22.88
5kkzQ-5fseC:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
4 / 7 HIS C 272
ILE C 271
VAL C 270
GLN C 418
None
1.16A 5kkzM-5fseC:
undetectable
5kkzO-5fseC:
undetectable
5kkzM-5fseC:
17.65
5kkzO-5fseC:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 PHE C 274
SER C 273
GLY C 278
GLY C 281
SER C 250
KCX  C 220 ( 4.4A)
None
None
None
None
1.12A 5kocB-5fseC:
undetectable
5kocB-5fseC:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 10 ALA C 217
LEU C 197
GLY C 160
ILE C 266
LEU C 263
None
KCX  C 220 ( 4.3A)
None
None
None
1.15A 5oy01-5fseC:
undetectable
5oy07-5fseC:
undetectable
5oy01-5fseC:
9.34
5oy07-5fseC:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)
5fse UREASE SUBUNIT GAMMA
(Sporosarcina
pasteurii)
5 / 8 ILE A  80
ASN A  31
LEU A  21
ALA A  20
LEU A  30
None
1.27A 5y7pC-5fseA:
undetectable
5y7pC-5fseA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5fse UREASE SUBUNIT ALPHA
(Sporosarcina
pasteurii)
5 / 12 SER C 496
THR C 156
ILE C 192
LEU C 219
PHE C 140
None
None
None
KCX  C 220 ( 4.0A)
None
1.24A 6a93A-5fseC:
undetectable
6a93A-5fseC:
21.73