SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5fsh CSM6
(Thermus
thermophilus) 		5 / 12 PHE A  50
ALA A 144
GLY A 147
PHE A 148
LEU A 119
 None
 1.24A 1qabF-5fshA:
undetectable		 1qabF-5fshA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5fsh CSM6
(Thermus
thermophilus) 		5 / 12 LEU A 367
GLY A 407
GLY A 410
GLY A 414
ARG A 415
 None
 1.06A 1y4lA-5fshA:
undetectable		 1y4lA-5fshA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5fsh CSM6
(Thermus
thermophilus) 		4 / 8 ALA A  63
ALA A  65
THR A  95
LEU A  99
 None
 1.02A 2wx2B-5fshA:
undetectable		 2wx2B-5fshA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5fsh CSM6
(Thermus
thermophilus) 		3 / 3 ASP A 195
PHE A 198
LEU A 202
 NI  A1467 (-2.2A)
None
None
 0.31A 2zi9A-5fshA:
undetectable		 2zi9A-5fshA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5fsh CSM6
(Thermus
thermophilus) 		4 / 8 VAL A 126
HIS A 123
TYR A 154
VAL A  52
 None
 1.03A 3fhxB-5fshA:
4.1		 3fhxB-5fshA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5fsh CSM6
(Thermus
thermophilus) 		4 / 8 ILE A 435
ALA A 439
LEU A 335
ALA A 305
 None
 0.89A 3hrdA-5fshA:
undetectable
3hrdB-5fshA:
undetectable		 3hrdA-5fshA:
23.65
3hrdB-5fshA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5fsh CSM6
(Thermus
thermophilus) 		4 / 8 ALA A  63
ALA A  65
THR A  95
LEU A  99
 None
 0.99A 3khmA-5fshA:
undetectable		 3khmA-5fshA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5fsh CSM6
(Thermus
thermophilus) 		4 / 8 ALA A  63
ALA A  65
THR A  95
LEU A  99
 None
 0.97A 3l4dD-5fshA:
undetectable		 3l4dD-5fshA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5fsh CSM6
(Thermus
thermophilus) 		5 / 12 LEU A  33
ARG A  38
GLY A 177
THR A 178
LEU A  69
 None
 1.20A 3okxB-5fshA:
undetectable		 3okxB-5fshA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 5fsh CSM6
(Thermus
thermophilus) 		4 / 7 THR A  59
PRO A  61
THR A  64
SER A 134
 None
 1.22A 5b6iA-5fshA:
undetectable		 5b6iA-5fshA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5fsh CSM6
(Thermus
thermophilus) 		5 / 10 ALA A 129
ALA A  73
VAL A  76
HIS A 123
HIS A  55
 None
 1.46A 5eb5B-5fshA:
undetectable		 5eb5B-5fshA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5fsh CSM6
(Thermus
thermophilus) 		4 / 4 VAL A 280
GLU A 284
GLY A 252
LEU A 256
 None
 1.00A 5g5gC-5fshA:
undetectable		 5g5gC-5fshA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5fsh CSM6
(Thermus
thermophilus) 		5 / 12 VAL A 162
ALA A  67
ARG A  90
GLY A  58
LEU A  57
 None
 1.22A 5m54E-5fshA:
2.8		 5m54E-5fshA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5fsh CSM6
(Thermus
thermophilus) 		5 / 9 SER A  53
GLY A  72
ALA A  73
GLY A  70
LEU A 181
 None
 1.14A 5vw4A-5fshA:
3.4		 5vw4A-5fshA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5fsh CSM6
(Thermus
thermophilus) 		3 / 3 LYS A 122
LEU A 119
ARG A 118
 None
 0.85A 5yw0A-5fshA:
undetectable		 5yw0A-5fshA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5fsh CSM6
(Thermus
thermophilus) 		3 / 3 ARG A 253
LEU A 249
PHE A 245
 None
 0.74A 6nknP-5fshA:
4.6		 6nknP-5fshA:
19.57