SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fsr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		4 / 5 LEU A 200
SER A 167
LEU A  46
GLY A 209
 None
 1.08A 1a4lB-5fsrA:
undetectable		 1a4lB-5fsrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		4 / 8 LEU A 116
ALA A 115
VAL A  69
VAL A  95
 None
 0.84A 1epbB-5fsrA:
undetectable		 1epbB-5fsrA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		4 / 8 TYR A  50
ASP A  53
TYR A  23
HIS A 172
 None
 1.31A 2bteA-5fsrA:
undetectable		 2bteA-5fsrA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		5 / 7 ILE A 234
ARG A 232
PRO A  11
GLY A 257
TRP A 256
 None
 1.38A 2pnjB-5fsrA:
undetectable		 2pnjB-5fsrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		3 / 3 GLU A 248
HIS A  14
GLU A 249
 None
 0.77A 2x45B-5fsrA:
undetectable		 2x45B-5fsrA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		3 / 3 GLU A 248
HIS A  14
GLU A 249
 None
 0.81A 2x45C-5fsrA:
undetectable		 2x45C-5fsrA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		5 / 12 ILE A 303
ILE A 306
ASP A 334
PHE A 294
GLN A  27
 None
 1.44A 2ya7B-5fsrA:
undetectable		 2ya7B-5fsrA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		5 / 12 ILE A 303
ILE A 306
ASP A 334
PHE A 294
GLN A  27
 None
 1.45A 2ya7D-5fsrA:
undetectable		 2ya7D-5fsrA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		5 / 12 THR A 143
ASP A  53
ILE A 170
ASP A 162
LEU A 166
 None
 1.32A 3iv6D-5fsrA:
undetectable		 3iv6D-5fsrA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		4 / 7 TYR A 161
HIS A  35
LEU A  29
GLN A  27
 None
 1.15A 3jwqC-5fsrA:
undetectable		 3jwqC-5fsrA:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		6 / 12 ALA A  41
LYS A  45
GLY A  83
ASN A 110
LEU A 151
ARG A 196
 None
 1.01A 3mzeA-5fsrA:
40.4		 3mzeA-5fsrA:
47.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		6 / 12 ALA A  41
LYS A  45
GLY A  83
ASN A 110
LEU A 151
GLY A 213
 None
 0.69A 3mzeA-5fsrA:
40.4		 3mzeA-5fsrA:
47.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		6 / 12 ALA A  41
SER A  42
LYS A  45
GLY A  83
LEU A 151
ARG A 196
 None
 1.11A 3mzeA-5fsrA:
40.4		 3mzeA-5fsrA:
47.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		6 / 12 ALA A  41
SER A  42
LYS A  45
GLY A  83
LEU A 151
GLY A 213
 None
 0.84A 3mzeA-5fsrA:
40.4		 3mzeA-5fsrA:
47.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		3 / 3 TYR A  23
MET A  47
LEU A 138
 None
 0.86A 3vw1D-5fsrA:
undetectable		 3vw1D-5fsrA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		4 / 6 LEU A 233
LEU A  29
ILE A   4
THR A  25
 None
 0.82A 4do3B-5fsrA:
undetectable		 4do3B-5fsrA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		4 / 7 ILE A  28
ALA A  31
TYR A 161
ALA A 164
 None
 0.69A 4g77A-5fsrA:
undetectable		 4g77A-5fsrA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		5 / 12 LEU A  43
GLY A 198
LEU A 199
VAL A 207
VAL A 236
 None
 1.00A 4wnwB-5fsrA:
undetectable		 4wnwB-5fsrA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		5 / 12 VAL A 297
LEU A 267
LEU A 332
VAL A 339
ALA A 340
 None
 1.19A 6ajiA-5fsrA:
undetectable		 6ajiA-5fsrA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD
(Escherichia
coli) 		5 / 11 ASP A 118
ALA A 115
LEU A  89
GLY A  70
PHE A  81
 None
 1.21A 6ieyA-5fsrA:
undetectable
6ieyB-5fsrA:
undetectable		 6ieyA-5fsrA:
23.60
6ieyB-5fsrA:
23.60