SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fsw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 12 LEU A 931
PHE A 497
GLY A 486
PHE A 483
PHE A 959
 None
 1.40A 1brpA-5fswA:
undetectable		 1brpA-5fswA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 12 ALA A 109
GLY A 112
GLU A  51
ALA A  47
PRO A 101
 None
 1.13A 1mjqC-5fswA:
undetectable
1mjqD-5fswA:
undetectable		 1mjqC-5fswA:
8.06
1mjqD-5fswA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 10 GLU A  51
ALA A  47
PRO A 101
ALA A 109
GLY A 112
 None
 1.13A 1mjqG-5fswA:
undetectable
1mjqH-5fswA:
undetectable		 1mjqG-5fswA:
8.06
1mjqH-5fswA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 12 ALA A 109
GLY A 112
GLU A  51
ALA A  47
PRO A 101
 None
 1.13A 1mjqI-5fswA:
undetectable
1mjqJ-5fswA:
undetectable		 1mjqI-5fswA:
8.06
1mjqJ-5fswA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		3 / 3 LEU A 416
HIS A 783
ILE A 784
 None
 0.67A 1s9pB-5fswA:
undetectable		 1s9pB-5fswA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		3 / 3 TYR A 688
ARG A 240
GLN A 202
 None
 0.99A 1tw4A-5fswA:
undetectable		 1tw4A-5fswA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 4 SER A 590
ILE A 592
VAL A 721
THR A 708
 None
 1.23A 1u70A-5fswA:
undetectable		 1u70A-5fswA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 12 LEU A 603
LEU A 606
VAL A 542
LEU A 367
ARG A 333
 None
 1.08A 2bxfA-5fswA:
1.1		 2bxfA-5fswA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 8 ASP A 664
LEU A 671
SER A 694
LEU A 288
 None
 1.06A 2q0iA-5fswA:
undetectable		 2q0iA-5fswA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 8 ASP A 591
PHE A 588
ARG A 583
ALA A 649
 None
 1.15A 2v7uA-5fswA:
2.9		 2v7uA-5fswA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		3 / 3 TYR A 987
GLU A 493
ASN A 470
 None
 0.95A 2y7hC-5fswA:
3.3		 2y7hC-5fswA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 12 LEU A 499
VAL A 465
VAL A 494
GLY A 492
ILE A 510
 None
 1.19A 3bf1A-5fswA:
undetectable
3bf1B-5fswA:
undetectable		 3bf1A-5fswA:
12.56
3bf1B-5fswA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 12 GLY A 954
GLY A 486
VAL A 949
PHE A 959
LEU A 829
 None
 1.15A 3dh0A-5fswA:
undetectable		 3dh0A-5fswA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 8 ASP A 632
ASP A 628
GLY A 330
ARG A 293
 None
 0.96A 3s3mA-5fswA:
undetectable		 3s3mA-5fswA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		3 / 3 LYS A 209
SER A 299
GLN A 295
 None
 1.32A 3si7A-5fswA:
undetectable		 3si7A-5fswA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 7 VAL A 234
VAL A 167
LEU A 127
ASN A 692
 None
 0.81A 4e1gB-5fswA:
undetectable		 4e1gB-5fswA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 5 GLU A  51
ARG A  54
PRO A 101
SER A 102
 None
 1.45A 4k17B-5fswA:
undetectable		 4k17B-5fswA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		3 / 3 ASP A 141
TRP A  83
SER A 124
 None
 1.08A 4lrhA-5fswA:
undetectable		 4lrhA-5fswA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		3 / 3 LEU A 857
MET A 952
TYR A 942
 None
 0.81A 4p6xG-5fswA:
undetectable		 4p6xG-5fswA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 12 SER A 384
GLY A 627
ASP A 622
ASP A 591
ASP A 738
 None
 1.34A 4pghB-5fswA:
undetectable		 4pghB-5fswA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 6 LEU A 277
LEU A 153
ILE A 691
PHE A 206
 None
 1.16A 4y4dA-5fswA:
undetectable		 4y4dA-5fswA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		3 / 3 VAL A 774
ALA A 776
PHE A 790
 None
 0.91A 4z4iA-5fswA:
undetectable		 4z4iA-5fswA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 5 LYS A 771
TYR A 770
ARG A 713
ASN A 709
 None
 1.22A 5bphB-5fswA:
0.0		 5bphB-5fswA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 12 GLY A 977
PHE A 483
PHE A 497
GLY A 486
GLY A 954
 None
 1.09A 5eqbA-5fswA:
undetectable		 5eqbA-5fswA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 8 LEU A 276
LEU A 396
THR A 301
GLN A 356
 None
 0.94A 5hbsA-5fswA:
undetectable		 5hbsA-5fswA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 6 LYS A 741
ASP A 628
GLY A 627
ASP A 632
 None
 1.42A 5hp1C-5fswA:
2.2		 5hp1C-5fswA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		3 / 3 VAL A 774
ALA A 776
PHE A 790
 None
 0.90A 5js1A-5fswA:
undetectable		 5js1A-5fswA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 10 ILE A 355
ILE A 331
GLY A 332
SER A 406
VAL A 542
 None
 1.13A 5twjB-5fswA:
undetectable		 5twjB-5fswA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 12 ILE A 355
ILE A 331
GLY A 332
SER A 406
VAL A 542
 None
 1.17A 5twjC-5fswA:
undetectable		 5twjC-5fswA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		5 / 10 VAL A 122
LEU A 123
SER A 124
LEU A 166
GLY A 150
 None
 1.20A 6eu9B-5fswA:
undetectable		 6eu9B-5fswA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1
(Thielavia
terrestris) 		4 / 8 ASP A 641
HIS A 532
ARG A 535
ASP A 564
 None
 1.26A 6mn4B-5fswA:
undetectable		 6mn4B-5fswA:
13.94