SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fsy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		3 / 3 ARG A 169
ILE A  57
TRP A  76
 None
 1.10A 1m8eB-5fsyA:
undetectable		 1m8eB-5fsyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		3 / 3 ARG A 169
ILE A  57
TRP A  76
 None
 0.96A 1nodB-5fsyA:
undetectable		 1nodB-5fsyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		3 / 3 ARG A 169
ILE A  57
TRP A  76
 None
 1.04A 1qomA-5fsyA:
undetectable		 1qomA-5fsyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		4 / 5 CYH A 207
PRO A 108
THR A 255
THR A 222
 AR6  A1262 ( 4.5A)
AR6  A1262 (-4.7A)
None
None
 1.46A 1ymxB-5fsyA:
undetectable		 1ymxB-5fsyA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		3 / 3 ARG A 169
ILE A  57
TRP A  76
 None
 0.96A 2nodB-5fsyA:
undetectable		 2nodB-5fsyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		3 / 3 ARG A 169
ILE A  57
TRP A  76
 None
 1.10A 3e68A-5fsyA:
undetectable		 3e68A-5fsyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		3 / 3 ARG A 169
ILE A  57
TRP A  76
 None
 1.07A 3e6tB-5fsyA:
undetectable		 3e6tB-5fsyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		3 / 3 ARG A 169
ILE A  57
TRP A  76
 None
 1.07A 3e7iB-5fsyA:
undetectable		 3e7iB-5fsyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		3 / 3 ARG A 169
ILE A  57
TRP A  76
 None
 1.05A 3nw2A-5fsyA:
undetectable		 3nw2A-5fsyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		3 / 3 ARG A 169
ILE A  57
TRP A  76
 None
 0.99A 3nw2B-5fsyA:
undetectable		 3nw2B-5fsyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		4 / 6 ASP A 115
SER A 203
ASP A 241
ARG A 202
 None
 1.23A 4eysA-5fsyA:
undetectable		 4eysA-5fsyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		5 / 12 ARG A 124
GLY A 152
ARG A 159
VAL A 213
TYR A 214
 None
None
None
AR6  A1262 (-3.7A)
AR6  A1262 (-3.5A)
 1.44A 4ffwA-5fsyA:
undetectable		 4ffwA-5fsyA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		5 / 12 GLU A 234
ILE A  98
LEU A 226
GLY A 227
VAL A 260
 None
 1.11A 4foxD-5fsyA:
undetectable		 4foxD-5fsyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		4 / 8 PRO A  91
LEU A 233
ILE A  98
LEU A 114
 None
 0.99A 5ieoA-5fsyA:
undetectable		 5ieoA-5fsyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		5 / 12 ILE A 192
VAL A 209
LEU A 218
VAL A 260
ILE A 102
 None
AR6  A1262 ( 4.5A)
None
None
None
 0.76A 5mugA-5fsyA:
undetectable		 5mugA-5fsyA:
19.57