SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 5fsz MACRODOMAIN
(Trypanosoma
cruzi) 		4 / 8 THR A 222
LEU A 186
THR A 167
VAL A 202
 None
 1.13A 1dz9A-5fszA:
undetectable		 1dz9A-5fszA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5fsz MACRODOMAIN
(Trypanosoma
cruzi) 		5 / 12 TYR A 249
ILE A 197
GLY A 198
VAL A 111
ASN A 112
 None
 1.09A 3jb3A-5fszA:
undetectable		 3jb3A-5fszA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5fsz MACRODOMAIN
(Trypanosoma
cruzi) 		4 / 8 GLY A 172
CYH A 200
PHE A 199
PHE A 238
 None
 1.09A 3ko0B-5fszA:
undetectable
3ko0J-5fszA:
undetectable		 3ko0B-5fszA:
16.67
3ko0J-5fszA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5fsz MACRODOMAIN
(Trypanosoma
cruzi) 		4 / 7 GLY A 172
CYH A 200
PHE A 199
PHE A 238
 None
 1.11A 3ko0K-5fszA:
undetectable
3ko0S-5fszA:
undetectable		 3ko0K-5fszA:
16.67
3ko0S-5fszA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fsz MACRODOMAIN
(Trypanosoma
cruzi) 		5 / 12 GLY A 123
ALA A 127
THR A 103
ILE A 110
ILE A 197
 None
 1.36A 3ld6A-5fszA:
undetectable		 3ld6A-5fszA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 5fsz MACRODOMAIN
(Trypanosoma
cruzi) 		5 / 12 VAL A 137
PHE A  51
VAL A  38
LEU A  39
ARG A  35
 None
 1.02A 4po0A-5fszA:
undetectable		 4po0A-5fszA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5fsz MACRODOMAIN
(Trypanosoma
cruzi) 		4 / 8 PRO A  84
LEU A 226
ILE A  91
LEU A 107
 None
 0.97A 5ieoA-5fszA:
undetectable		 5ieoA-5fszA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5fsz MACRODOMAIN
(Trypanosoma
cruzi) 		4 / 7 ALA A 127
GLY A 123
GLY A 121
THR A 103
 None
 0.82A 5ybbB-5fszA:
undetectable		 5ybbB-5fszA:
19.56