SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ft3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 THR A 144
ASP A 159
ILE A 157
TYR A  86
GLN A  93
 None
 1.16A 1oltA-5ft3A:
undetectable		 1oltA-5ft3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 PHE A 108
PHE A 120
LEU A  36
VAL A  34
PHE A  46
 GSH  A1221 (-3.8A)
None
GSH  A1221 (-3.7A)
None
None
 1.17A 1q23C-5ft3A:
undetectable		 1q23C-5ft3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 11 PHE A 108
PHE A 120
LEU A  36
VAL A  34
PHE A  46
 GSH  A1221 (-3.8A)
None
GSH  A1221 (-3.7A)
None
None
 1.16A 1q23L-5ft3A:
undetectable		 1q23L-5ft3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		4 / 6 THR A  54
VAL A  55
CYH A  15
SER A  12
 GSH  A1221 (-3.1A)
GSH  A1221 (-4.1A)
None
GSH  A1221 (-2.5A)
 1.20A 3b6rB-5ft3A:
undetectable		 3b6rB-5ft3A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 ALA A  24
ILE A 157
ARG A  16
ILE A  71
LEU A   6
 None
 1.13A 3k2hB-5ft3A:
undetectable		 3k2hB-5ft3A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 VAL A  11
PRO A  13
GLU A 103
HIS A  69
GLY A 105
 None
GSH  A1221 ( 4.2A)
None
GSH  A1221 (-4.4A)
None
 1.49A 4olfA-5ft3A:
undetectable		 4olfA-5ft3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 VAL A 207
PRO A  13
GLU A 103
HIS A  69
GLY A 105
 None
GSH  A1221 ( 4.2A)
None
GSH  A1221 (-4.4A)
None
 1.49A 4olfA-5ft3A:
undetectable		 4olfA-5ft3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 VAL A 207
PRO A  13
GLU A 103
HIS A  69
GLY A 105
 None
GSH  A1221 ( 4.2A)
None
GSH  A1221 (-4.4A)
None
 1.45A 4ydqB-5ft3A:
undetectable		 4ydqB-5ft3A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		4 / 7 LEU A 155
TRP A 186
VAL A 166
SER A 165
 None
 1.08A 5umwA-5ft3A:
undetectable
5umwF-5ft3A:
undetectable		 5umwA-5ft3A:
19.29
5umwF-5ft3A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		4 / 7 TRP A 186
VAL A 166
GLU A 103
SER A 165
 None
 1.31A 5umwA-5ft3A:
undetectable
5umwF-5ft3A:
undetectable		 5umwA-5ft3A:
19.29
5umwF-5ft3A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 VAL A 207
PRO A  13
GLU A 103
HIS A  69
GLY A 105
 None
GSH  A1221 ( 4.2A)
None
GSH  A1221 (-4.4A)
None
 1.42A 5xioA-5ft3A:
undetectable		 5xioA-5ft3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 LEU A 145
GLY A 185
TYR A 184
MET A 175
LEU A 141
 None
 1.09A 6f6iA-5ft3A:
undetectable
6f6iB-5ft3A:
undetectable		 6f6iA-5ft3A:
16.51
6f6iB-5ft3A:
18.41