SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ftf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		4 / 6 LEU A 115
ASP A 119
LEU A 122
GLY A 133
 None
 0.85A 1mt1G-5ftfA:
undetectable
1mt1J-5ftfA:
undetectable		 1mt1G-5ftfA:
7.62
1mt1J-5ftfA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		4 / 6 LEU A 115
ASP A 119
LEU A 122
GLY A 133
 None
 0.83A 1n13H-5ftfA:
undetectable
1n13K-5ftfA:
undetectable		 1n13H-5ftfA:
13.98
1n13K-5ftfA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		4 / 7 LEU A 115
ASP A 119
LEU A 122
GLY A 133
 None
 0.85A 1n13G-5ftfA:
undetectable
1n13J-5ftfA:
undetectable		 1n13G-5ftfA:
7.62
1n13J-5ftfA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		4 / 5 SER A 267
SER A 268
PHE A  75
PHE A 264
 None
 1.24A 1oipA-5ftfA:
undetectable		 1oipA-5ftfA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		4 / 5 ASP A 315
LEU A 299
MET A 284
ARG A 282
 None
 1.36A 2gj5A-5ftfA:
undetectable		 2gj5A-5ftfA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 12 ARG A 175
PRO A 131
GLY A 429
THR A 176
ILE A 180
 None
 1.37A 3iv6C-5ftfA:
undetectable		 3iv6C-5ftfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 12 ILE A 118
LEU A 115
ALA A  53
THR A  55
VAL A 110
 None
 1.03A 3rukA-5ftfA:
undetectable		 3rukA-5ftfA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 12 ILE A 118
ILE A 114
LEU A 115
ALA A  53
THR A  55
 None
 0.96A 3rukB-5ftfA:
undetectable		 3rukB-5ftfA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 12 ILE A 118
ILE A 114
LEU A 115
THR A  55
VAL A 110
 None
 1.01A 3rukB-5ftfA:
undetectable		 3rukB-5ftfA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		4 / 8 PHE A 264
THR A 330
GLY A  56
SER A 267
 None
 0.99A 3tzfB-5ftfA:
undetectable		 3tzfB-5ftfA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		4 / 5 GLU A 130
ASP A  20
ASP A 119
ASN A  23
 None
 1.38A 3vywD-5ftfA:
undetectable		 3vywD-5ftfA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		3 / 3 ARG A 324
PHE A 350
PRO A 351
 None
 0.52A 3zoaB-5ftfA:
undetectable		 3zoaB-5ftfA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		4 / 7 ASN A  61
GLY A  63
THR A 330
PHE A 264
 None
 1.02A 4ejjB-5ftfA:
undetectable		 4ejjB-5ftfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 12 LEU A  38
ILE A 103
ILE A 104
GLY A  64
ALA A  59
 None
 1.00A 4nkvA-5ftfA:
undetectable		 4nkvA-5ftfA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 12 ILE A 118
ILE A 114
LEU A 115
ALA A  53
THR A  55
 None
 0.97A 4nkvB-5ftfA:
undetectable		 4nkvB-5ftfA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 12 LEU A  38
ILE A 103
ILE A 104
GLY A  64
ALA A  59
 None
 0.99A 4nkvC-5ftfA:
undetectable		 4nkvC-5ftfA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		4 / 8 LEU A 122
LEU A  67
HIS A  68
ILE A  78
 None
 0.93A 4ok1A-5ftfA:
undetectable		 4ok1A-5ftfA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 11 GLN A 364
GLY A  56
THR A  55
ALA A  53
THR A  66
 None
 1.42A 4qvqV-5ftfA:
undetectable
4qvqW-5ftfA:
undetectable		 4qvqV-5ftfA:
20.24
4qvqW-5ftfA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 12 ILE A 104
ILE A 107
VAL A 135
LEU A 122
PHE A 132
 None
 0.98A 4y0pA-5ftfA:
undetectable		 4y0pA-5ftfA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 11 GLY A 141
THR A  36
THR A  35
ARG A 202
GLY A 365
 None
ADP  A1432 (-3.5A)
ADP  A1432 (-3.5A)
None
None
 1.33A 5w97A-5ftfA:
undetectable
5w97B-5ftfA:
undetectable
5w97g-5ftfA:
undetectable		 5w97A-5ftfA:
20.85
5w97B-5ftfA:
20.09
5w97g-5ftfA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5ftf TPR DOMAIN PROTEIN
(Bacteroides
sp.
3_1_23) 		5 / 9 GLY A 141
THR A  36
THR A  35
ARG A 202
GLY A 365
 None
ADP  A1432 (-3.5A)
ADP  A1432 (-3.5A)
None
None
 1.39A 6nmpA-5ftfA:
0.0
6nmpB-5ftfA:
0.0
6nmpT-5ftfA:
0.0		 6nmpA-5ftfA:
20.85
6nmpB-5ftfA:
20.09
6nmpT-5ftfA:
10.20