SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ftg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 GLU A 227
ILE A 224
ARG A 212
 None
 0.81A 1cd2A-5ftgA:
undetectable		 1cd2A-5ftgA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 7 GLN A 308
TRP A 420
TRP A 423
ASN A 345
 NBR  A1458 ( 3.3A)
NBR  A1458 (-3.4A)
NBR  A1458 ( 3.5A)
NBR  A1458 ( 4.9A)
 1.14A 1jqdA-5ftgA:
undetectable		 1jqdA-5ftgA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
ASP A 306
 None
None
None
None
EDO  A1466 ( 3.0A)
 1.39A 1p7lD-5ftgA:
undetectable		 1p7lD-5ftgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
ASP A 306
 None
None
None
None
EDO  A1466 ( 3.0A)
 1.38A 1rg9A-5ftgA:
undetectable		 1rg9A-5ftgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
ASP A 306
 None
None
None
None
EDO  A1466 ( 3.0A)
 1.38A 1rg9C-5ftgA:
undetectable		 1rg9C-5ftgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
ASP A 306
 None
None
None
None
EDO  A1466 ( 3.0A)
 1.38A 1rg9D-5ftgA:
undetectable		 1rg9D-5ftgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 7 LEU A 147
MET A 177
VAL A 178
SER A 181
 None
 1.04A 1wrlA-5ftgA:
undetectable
1wrlB-5ftgA:
undetectable		 1wrlA-5ftgA:
14.24
1wrlB-5ftgA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 10 ALA A  91
LEU A 145
TRP A 103
PHE A 111
LEU A 205
 None
 1.34A 1y7iB-5ftgA:
undetectable		 1y7iB-5ftgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 8 GLN A 308
TYR A 256
TRP A 420
THR A 252
 NBR  A1458 ( 3.3A)
None
NBR  A1458 (-3.4A)
None
 1.40A 2vxaF-5ftgA:
undetectable
2vxaG-5ftgA:
undetectable
2vxaI-5ftgA:
undetectable		 2vxaF-5ftgA:
12.96
2vxaG-5ftgA:
12.96
2vxaI-5ftgA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 10 LEU A 422
ALA A 441
VAL A 260
SER A 431
ILE A 430
 None
 1.11A 2w9hA-5ftgA:
undetectable		 2w9hA-5ftgA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 SER A 114
THR A  87
PHE A 200
 EDO  A1463 (-2.8A)
None
None
 0.78A 2x91A-5ftgA:
undetectable		 2x91A-5ftgA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 ASP A 306
GLU A 349
TYR A 354
TRP A 423
PHE A 435
TYR A 440
 EDO  A1466 ( 3.0A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.7A)
NBR  A1458 (-4.0A)
 0.42A 3mesA-5ftgA:
35.6		 3mesA-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 420
TRP A 423
TYR A 440
 NBR  A1458 ( 3.3A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 (-3.4A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.0A)
 0.76A 3mesA-5ftgA:
35.6		 3mesA-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 423
PHE A 435
TYR A 440
 NBR  A1458 ( 3.3A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.7A)
NBR  A1458 (-4.0A)
 0.59A 3mesA-5ftgA:
35.6		 3mesA-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 ASP A 306
GLU A 349
TYR A 354
TRP A 423
PHE A 435
TYR A 440
 EDO  A1466 ( 3.0A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.7A)
NBR  A1458 (-4.0A)
 0.44A 3mesB-5ftgA:
35.6		 3mesB-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 420
TRP A 423
TYR A 440
 NBR  A1458 ( 3.3A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 (-3.4A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.0A)
 0.75A 3mesB-5ftgA:
35.6		 3mesB-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 423
PHE A 435
TYR A 440
 NBR  A1458 ( 3.3A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.7A)
NBR  A1458 (-4.0A)
 0.60A 3mesB-5ftgA:
35.6		 3mesB-5ftgA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
 0.87A 4uroA-5ftgA:
undetectable		 4uroA-5ftgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
 0.99A 4uroB-5ftgA:
undetectable		 4uroB-5ftgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
 0.91A 4uroC-5ftgA:
undetectable		 4uroC-5ftgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
NBR  A1458 ( 3.3A)
None
None
 1.16A 4w5qA-5ftgA:
undetectable		 4w5qA-5ftgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
NBR  A1458 ( 3.3A)
None
None
 1.10A 4w5tA-5ftgA:
undetectable		 4w5tA-5ftgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 LEU A 289
LEU A 286
LEU A 282
HIS A 417
LEU A 249
 None
None
None
EDO  A1468 (-4.0A)
None
 0.96A 4zn7A-5ftgA:
undetectable		 4zn7A-5ftgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 10 ILE A 343
LEU A 219
LEU A 326
PHE A 378
SER A 225
 None
EDO  A1459 (-4.5A)
None
None
None
 1.46A 5tixB-5ftgA:
undetectable		 5tixB-5ftgA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
NBR  A1458 ( 3.3A)
None
None
 1.17A 6cbdA-5ftgA:
undetectable		 6cbdA-5ftgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 LEU A 414
LEU A 292
ARG A 411
 None
 0.64A 6fgcA-5ftgA:
undetectable		 6fgcA-5ftgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 LEU A 414
LEU A 292
ARG A 411
 None
 0.67A 6fgdA-5ftgA:
undetectable		 6fgdA-5ftgA:
21.66