SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ftp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ9_A_CAMA503_0 (CYTOCHROME P450-CAM)	5ftp	ANAPHASE-PROMOTING COMPLEX SUBUNIT 8 (Schizosaccharomy ces pombe)	4 / 8	PHE A 206 LEU A 178 VAL A 181 THR A 147	None	1.16A	1dz9A-5ftpA: undetectable	1dz9A-5ftpA: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1J8U_A_H4BA429_1 (PHENYLALANINE-4-HYDR OXYLASE)	5ftp	ANAPHASE-PROMOTING COMPLEX SUBUNIT 8 (Schizosaccharomy ces pombe)	5 / 7	VAL A 161 LEU A 123 SER A 125 LEU A 121 ALA A 106	None	1.37A	1j8uA-5ftpA: undetectable	1j8uA-5ftpA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_C_MTXC164_2 (DIHYDROFOLATE REDUCTASE)	5ftp	ANAPHASE-PROMOTING COMPLEX SUBUNIT 8 (Schizosaccharomy ces pombe)	4 / 4	ILE A 235 ARG A 276 ILE A 239 THR A 233	None	1.21A	3ia4C-5ftpA: undetectable	3ia4C-5ftpA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP6_B_SALB3003_1 (TRANSCRIPTIONAL REGULATOR TCAR)	5ftp	ANAPHASE-PROMOTING COMPLEX SUBUNIT 8 (Schizosaccharomy ces pombe)	4 / 6	ILE A 158 VAL A 161 LEU A 165 LEU A 175	None	0.78A	3kp6A-5ftpA: undetectable 3kp6B-5ftpA: undetectable	3kp6A-5ftpA: 19.57 3kp6B-5ftpA: 19.57

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DZ9_A_CAMA503_0","CYTOCHROME P450-CAM","5ftp","ANAPHASE-PROMOTING COMPLEX SUBUNIT 8","Schizosaccharomyces pombe",4,"PHE A 206;LEU A 178;VAL A 181;THR A 147","None","1.16A","1dz9A-5ftpA:undetectable","1dz9A-5ftpA:21.55"],["1J8U_A_H4BA429_1","PHENYLALANINE-4-HYDROXYLASE","5ftp","ANAPHASE-PROMOTING COMPLEX SUBUNIT 8","Schizosaccharomyces pombe",5,"VAL A 161;LEU A 123;SER A 125;LEU A 121;ALA A 106","None","1.37A","1j8uA-5ftpA:undetectable","1j8uA-5ftpA:21.59"],["3IA4_C_MTXC164_2","DIHYDROFOLATE REDUCTASE","5ftp","ANAPHASE-PROMOTING COMPLEX SUBUNIT 8","Schizosaccharomyces pombe",4,"ILE A 235;ARG A 276;ILE A 239;THR A 233","None","1.21A","3ia4C-5ftpA:undetectable","3ia4C-5ftpA:19.86"],["3KP6_B_SALB3003_1","TRANSCRIPTIONAL REGULATOR TCAR;TRANSCRIPTIONAL REGULATOR TCAR","5ftp","ANAPHASE-PROMOTING COMPLEX SUBUNIT 8","Schizosaccharomyces pombe",4,"ILE A 158;VAL A 161;LEU A 165;LEU A 175","None","0.78A","3kp6A-5ftpA:undetectable;3kp6B-5ftpA:undetectable","3kp6A-5ftpA:19.57;3kp6B-5ftpA:19.57"]]