SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ftt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		3 / 3 TRP C 447
VAL C 435
TRP C 226
 None
CA  C1467 (-4.8A)
None
 0.80A 1gmkC-5fttC:
undetectable
1gmkD-5fttC:
undetectable		 1gmkC-5fttC:
5.14
1gmkD-5fttC:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		5 / 12 GLY C 284
GLN C 232
ILE C 305
PHE C 299
LEU C 301
 None
 1.49A 1m2zD-5fttC:
undetectable		 1m2zD-5fttC:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		5 / 12 HIS C 451
ASN C 449
GLU C 396
GLN C 430
VAL C 446
 None
 1.40A 1qu3A-5fttC:
undetectable		 1qu3A-5fttC:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		4 / 6 TYR C 238
TYR C 268
GLY C 284
ASP C 283
 None
 1.22A 2g72A-5fttC:
undetectable		 2g72A-5fttC:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5ftt NETRIN RECEPTOR
UNC5D
(Rattus
norvegicus) 		4 / 8 HIS A 212
ILE A 198
ALA A 232
GLU A 190
 None
 0.91A 2x0pA-5fttA:
undetectable		 2x0pA-5fttA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		4 / 7 TYR C 411
VAL C 354
TYR C 409
ILE C 343
 None
 1.33A 2xz5B-5fttC:
undetectable
2xz5E-5fttC:
undetectable		 2xz5B-5fttC:
20.94
2xz5E-5fttC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 5ftt NETRIN RECEPTOR
UNC5D
(Rattus
norvegicus) 		4 / 6 ASP A 199
ILE A 198
LEU A 214
GLU A 190
 None
 0.92A 2ya7B-5fttA:
undetectable		 2ya7B-5fttA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 5ftt NETRIN RECEPTOR
UNC5D
(Rattus
norvegicus) 		4 / 6 ASP A 199
ILE A 198
LEU A 214
GLU A 190
 None
 0.95A 2ya7D-5fttA:
undetectable		 2ya7D-5fttA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		4 / 8 ILE C 237
TRP C 226
PHE C 217
TYR C 253
 None
 1.29A 3ccfB-5fttC:
undetectable		 3ccfB-5fttC:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		3 / 3 TRP C 226
ALA C 433
VAL C 446
 None
 0.99A 3l8lA-5fttC:
undetectable
3l8lB-5fttC:
undetectable		 3l8lA-5fttC:
5.14
3l8lB-5fttC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		5 / 11 LEU C 444
VAL C 423
VAL C 391
TYR C 389
LEU C 457
 None
 1.17A 3m8pA-5fttC:
undetectable
3m8pB-5fttC:
undetectable		 3m8pA-5fttC:
21.03
3m8pB-5fttC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		5 / 9 ALA C 334
GLY C 386
ILE C 387
ILE C 353
ILE C 343
 None
 0.85A 3s43A-5fttC:
undetectable		 3s43A-5fttC:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		5 / 9 ALA C 334
GLY C 386
ILE C 387
ILE C 353
ILE C 343
 None
 0.94A 3s45A-5fttC:
undetectable		 3s45A-5fttC:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		5 / 11 ALA C 334
GLY C 386
ILE C 387
ILE C 353
ILE C 343
 None
 0.86A 3s53B-5fttC:
undetectable		 3s53B-5fttC:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		3 / 3 TRP C 447
VAL C 435
TRP C 226
 None
CA  C1467 (-4.8A)
None
 1.24A 3zq8C-5fttC:
undetectable
3zq8D-5fttC:
undetectable		 3zq8C-5fttC:
5.14
3zq8D-5fttC:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		4 / 8 PHE C 382
VAL C 435
ILE C 432
ASN C 380
 None
CA  C1467 (-4.8A)
None
CA  C1467 (-3.7A)
 1.03A 4a97C-5fttC:
undetectable		 4a97C-5fttC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		4 / 8 ASP C 330
SER C 329
ASN C 289
THR C 247
 None
 0.88A 4fo4A-5fttC:
undetectable		 4fo4A-5fttC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		4 / 7 LEU C 111
ALA C 124
LEU C 185
LEU C 102
 None
 0.86A 4ubsA-5fttC:
undetectable		 4ubsA-5fttC:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		5 / 12 ALA C 334
GLY C 386
ILE C 387
ILE C 353
ILE C 343
 None
 0.82A 5e5jA-5fttC:
undetectable		 5e5jA-5fttC:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		5 / 12 ALA C 334
GLY C 386
ILE C 387
ILE C 353
ILE C 343
 None
 0.84A 5e5kB-5fttC:
undetectable		 5e5kB-5fttC:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3
(Mus
musculus) 		3 / 3 LYS C 298
GLN C 357
ASN C 359
 None
 1.02A 5l2tA-5fttC:
undetectable		 5l2tA-5fttC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ftt NETRIN RECEPTOR
UNC5D
(Rattus
norvegicus) 		4 / 6 TYR A  62
ILE A 234
ALA A 186
ASP A 129
 None
 1.06A 6hu9m-5fttA:
undetectable
6hu9q-5fttA:
undetectable		 6hu9m-5fttA:
18.60
6hu9q-5fttA:
18.71