SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ftw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ADM_A_SAMA500_0 (ADENINE-N6-DNA-METHY LTRANSFERASE TAQI)	5ftw	CHEMOTAXIS PROTEIN METHYLTRANSFERASE (Bacillus subtilis)	5 / 11	ALA A 101 PRO A 108 ILE A 131 ASP A 132 ALA A 135	SAH A1257 (-3.5A) None SAH A1257 (-4.0A) None None	1.09A	2admA-5ftwA: 10.2	2admA-5ftwA: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HZQ_A_STRA300_1 (APOLIPOPROTEIN D)	5ftw	CHEMOTAXIS PROTEIN METHYLTRANSFERASE (Bacillus subtilis)	4 / 7	THR A 65 TYR A 191 ASN A 185 LEU A 215	SAH A1257 (-3.6A) None SAH A1257 (-3.8A) None	1.10A	2hzqA-5ftwA: undetectable	2hzqA-5ftwA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P6H_A_IBPA133_1 (FATTY ACID-BINDING PROTEIN, ADIPOCYTE)	5ftw	CHEMOTAXIS PROTEIN METHYLTRANSFERASE (Bacillus subtilis)	4 / 7	PHE A 181 ILE A 175 VAL A 171 TYR A 144	None	1.08A	3p6hA-5ftwA: undetectable	3p6hA-5ftwA: 17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EQB_A_1YNA602_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5ftw	CHEMOTAXIS PROTEIN METHYLTRANSFERASE (Bacillus subtilis)	4 / 4	TYR A 72 TYR A 124 PRO A 108 THR A 173	None None None SO4 A1260 (-3.7A)	1.45A	5eqbA-5ftwA: 0.0	5eqbA-5ftwA: 18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NCS_A_ACTA303_0 (N-ACETYLNEURAMINIC ACID (SIALIC ACID) SYNTHETASE)	5ftw	CHEMOTAXIS PROTEIN METHYLTRANSFERASE (Bacillus subtilis)	3 / 3	ILE A 179 THR A 180 PRO A 108	None	0.54A	6ncsA-5ftwA: undetectable	6ncsA-5ftwA: 23.64

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ADM_A_SAMA500_0","ADENINE-N6-DNA-METHYLTRANSFERASE TAQI","5ftw","CHEMOTAXIS PROTEIN METHYLTRANSFERASE","Bacillus subtilis",5,"ALA A 101;PRO A 108;ILE A 131;ASP A 132;ALA A 135","SAH A1257 (-3.5A);None;SAH A1257 (-4.0A);None;None","1.09A","2admA-5ftwA:10.2","2admA-5ftwA:22.30"],["2HZQ_A_STRA300_1","APOLIPOPROTEIN D","5ftw","CHEMOTAXIS PROTEIN METHYLTRANSFERASE","Bacillus subtilis",4,"THR A  65;TYR A 191;ASN A 185;LEU A 215","SAH A1257 (-3.6A);None;SAH A1257 (-3.8A);None","1.10A","2hzqA-5ftwA:undetectable","2hzqA-5ftwA:21.60"],["3P6H_A_IBPA133_1","FATTY ACID-BINDING PROTEIN, ADIPOCYTE","5ftw","CHEMOTAXIS PROTEIN METHYLTRANSFERASE","Bacillus subtilis",4,"PHE A 181;ILE A 175;VAL A 171;TYR A 144","None","1.08A","3p6hA-5ftwA:undetectable","3p6hA-5ftwA:17.76"],["5EQB_A_1YNA602_2","LANOSTEROL 14-ALPHA DEMETHYLASE","5ftw","CHEMOTAXIS PROTEIN METHYLTRANSFERASE","Bacillus subtilis",4,"TYR A  72;TYR A 124;PRO A 108;THR A 173","None;None;None;SO4 A1260 (-3.7A)","1.45A","5eqbA-5ftwA:0.0","5eqbA-5ftwA:18.72"],["6NCS_A_ACTA303_0","N-ACETYLNEURAMINIC ACID (SIALIC ACID) SYNTHETASE","5ftw","CHEMOTAXIS PROTEIN METHYLTRANSFERASE","Bacillus subtilis",3,"ILE A 179;THR A 180;PRO A 108","None","0.54A","6ncsA-5ftwA:undetectable","6ncsA-5ftwA:23.64"]]