SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ftx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 522
ALA A 487
THR A 455
THR A 484
 None
 0.92A 1c9sT-5ftxA:
undetectable
1c9sU-5ftxA:
undetectable		 1c9sT-5ftxA:
7.99
1c9sU-5ftxA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 786
LEU A 787
ALA A 784
ILE A 831
LEU A 774
 None
 1.03A 1g50A-5ftxA:
undetectable		 1g50A-5ftxA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 522
ALA A 487
THR A 455
THR A 484
 None
 0.84A 1gtnA-5ftxA:
undetectable
1gtnK-5ftxA:
undetectable		 1gtnA-5ftxA:
7.99
1gtnK-5ftxA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 606
GLU A 614
ASP A 660
 None
None
CA  A2104 (-3.0A)
 0.89A 2avdB-5ftxA:
undetectable		 2avdB-5ftxA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 868
ASP A 757
ASP A 728
 None
 0.96A 2br4A-5ftxA:
undetectable		 2br4A-5ftxA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 VAL A 603
THR A 602
VAL A 622
GLY A 621
 None
 1.16A 2p2fB-5ftxA:
undetectable		 2p2fB-5ftxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 542
VAL A 541
VAL A 547
LEU A 454
ILE A 545
 None
 1.39A 3elzA-5ftxA:
undetectable		 3elzA-5ftxA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A1024
LEU A1011
VAL A1061
ILE A1088
THR A1052
 None
 1.30A 3fl9H-5ftxA:
undetectable		 3fl9H-5ftxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A1047
ILE A1039
THR A 948
 None
 0.69A 3ia4D-5ftxA:
undetectable		 3ia4D-5ftxA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 454
TYR A 583
THR A 548
TYR A 465
 None
 1.30A 3wipF-5ftxA:
undetectable
3wipJ-5ftxA:
undetectable		 3wipF-5ftxA:
17.74
3wipJ-5ftxA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 570
ILE A 689
ALA A 573
ALA A 682
ASP A 684
 None
 1.11A 4kicA-5ftxA:
undetectable		 4kicA-5ftxA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 570
ILE A 689
ALA A 573
ALA A 682
ASP A 684
 None
 1.10A 4kicB-5ftxA:
undetectable		 4kicB-5ftxA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A 780
ALA A 784
LEU A 783
GLY A 848
ILE A 869
 None
 1.04A 4kt0A-5ftxA:
undetectable
4kt0J-5ftxA:
undetectable		 4kt0A-5ftxA:
23.35
4kt0J-5ftxA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 812
LYS A 768
ALA A 788
 None
 1.41A 4ot2A-5ftxA:
undetectable		 4ot2A-5ftxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 522
ALA A 487
THR A 455
THR A 484
 None
 0.91A 5eevL-5ftxA:
undetectable
5eevV-5ftxA:
undetectable		 5eevL-5ftxA:
7.99
5eevV-5ftxA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 522
ALA A 487
THR A 455
THR A 484
 None
 0.91A 5eewL-5ftxA:
undetectable
5eewV-5ftxA:
undetectable		 5eewL-5ftxA:
7.99
5eewV-5ftxA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 522
ALA A 487
THR A 455
THR A 484
 None
 0.91A 5ef3L-5ftxA:
undetectable
5ef3V-5ftxA:
undetectable		 5ef3L-5ftxA:
7.99
5ef3V-5ftxA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A 680
TYR A 653
GLN A 654
 None
 0.57A 5qgkA-5ftxA:
undetectable		 5qgkA-5ftxA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A 680
TYR A 653
GLN A 654
 None
 0.59A 5qgrA-5ftxA:
undetectable		 5qgrA-5ftxA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ftx SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A 680
TYR A 653
GLN A 654
 None
 0.59A 5qgtA-5ftxA:
undetectable		 5qgtA-5ftxA:
15.36