SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5fu5 CBM77-RFPL
(Ruminococcus
flavefaciens) 		5 / 10 ALA A1095
THR A1094
VAL A1127
GLY A1099
ASP A1071
 None
 1.03A 2f16K-5fu5A:
undetectable
2f16L-5fu5A:
undetectable		 2f16K-5fu5A:
22.17
2f16L-5fu5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5fu5 CBM77-RFPL
(Ruminococcus
flavefaciens) 		4 / 5 PHE A1072
ILE A1084
GLY A1086
THR A1112
 None
 0.95A 4ejjC-5fu5A:
undetectable		 4ejjC-5fu5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5fu5 CBM77-RFPL
(Ruminococcus
flavefaciens) 		4 / 5 ASN A1087
LEU A1088
THR A1112
CYH A1105
 None
 1.26A 5eu8A-5fu5A:
undetectable		 5eu8A-5fu5A:
17.26